Senior Principal Scientist | Agentic AI for Drug Discovery
Vertex Pharmaceuticals Inc (US)
Vertex Pharmaceuticals Inc in Boston seeks a Senior Principal Scientist to develop and deploy AI-enabled scientific workflows for drug discovery, focusing on small molecules. You will collaborate with cross-functional teams to translate scientific requirements into production-grade AI solutions. The role requires a Ph.D. in Computational Chemistry or Cheminformatics and 8+ years in scientific software development, with hybrid on-site work and opportunities to advance agentic AI initiatives. #J-18808-Ljbffr Vertex Pharmaceuticals Inc (US)
- ...to accelerate the application of AI and agentic systems across drug discovery. Working at the intersection of Computational... ...scientifically rigorous AI co-scientists that enhance compound design,... ..., engineers, data scientists, and senior leaders across a matrixed...PrincipalSeniorFull timeSummer workRemote workFlexible hours2 days per week3 days per week
- Vertex Pharmaceuticals Incorporated seeks a Senior Principal Scientist to develop and deploy AI-enabled scientific workflows for drug discovery, spanning small molecules and proteins. You will lead cross-disciplinary teams and translate scientific requirements into production...PrincipalSenior
- Vertex Pharmaceuticals, a leading biotechnology company, seeks a Senior Principal Scientist to develop, test, and deploy AI-enabled methods for drug discovery across small molecules and proteins. The role is Boston-based with a hybrid work arrangement (3 days onsite weekly...PrincipalSenior
- Job DescriptionVertex is seeking an accomplished Senior Principal Scientist with proven record of developing, testing and deploying scientific computational methods and agentic AI systems for drug discovery. In this role, you will work across modalities with emphasis on...PrincipalSeniorFull timeSummer workRemote workFlexible hours2 days per week3 days per week
$119.7k - $222.3k
...artificial intelligence (AI) enabled strategies to... .... Experience in late discovery into clinical... ...therapeutic proteins, antibody drug-conjugates,... ...to be considered for Principal Scientist II. 4+ years of experience... ...to be considered for Senior Principal Scientist.Extensive...PrincipalSeniorFull time$148.5k - $214.5k
Job title: Senior Principal Scientist/Principal Scientist, Real-World Evidence &... ...will help shape the future of drug discovery and development across... ...immunoscience meets bold, AI-powered research. In R&D, you... ...development Experience with agentic AI frameworks and their application...PrincipalSeniorFull time$137k - $215.27k
...a skilled cheminformatic scientist to join Takeda’s cheminformatics... ...learning to accelerate drug design. The candidate will... ...chemistry, DMPK, and AI/ML, defining a roadmap for... ...Accountabilities: Develop and apply agentic AI solutions for drug discovery, including autonomous or...SeniorMinimum wageLocal area$179k - $236k
...of Cellarity's platform for drug discovery. You will be part of a small... ...biologists, machine learning scientists, experimental biologists,... ...model them, use our single-cell AI models to predict chemical entities... ...coding assistants, LLMs, and agentic workflows), while maintaining...PrincipalSeniorFull timeShift work$115k - $215k
...recommendations to project teams, senior leadership, and external... ...proteomics strategies that inform discovery, translational, and clinical-... ...making within fast-paced drug discovery environments.... ...organized, solutions-oriented scientist with the ability to manage multiple...PrincipalSenior- UCB in Cambridge, MA is seeking a Senior Principal Scientist to lead translational biology drug discovery with emphasis on muscle biology. You will shape in vitro and in vivo models and develop cellular and biochemical assays for early programs across multiple neuromuscular...PrincipalSenior
$214.1k - $337k
Job DescriptionSenior Principal Scientist - Boston, MAOverviewWe are seeking a Senior Principal Scientist to provide scientific... ...for mass spectrometry-enabled discovery within the Quantitative Biosciences... ...development and application to drug discovery.Strong understanding...PrincipalSeniorFull timeFor contractorsLocal area$215k - $275k
...analytics, automation, and AI-native delivery to... ...learning, generative AI, agentic workflows, modern data... ...thought leadership.* Develop senior practitioners and... ..., architects, and data scientists. Set clear expectations... ...salary pay range for a Sr. Principal is $215,000 to $275,000...PrincipalSeniorTemporary workLocal area$138.6k - $257.4k
...Research is seeking an accomplished Imaging Scientist to join the Image Analysis team in... ...pathology, computational image analysis, AI/ML, and tissue-based oncology biomarkers... ...microenvironment biologyExperience supporting oncology drug discovery or early clinical development with image...PrincipalSeniorFull time- We are seeking a Senior Principal Scientist to join the US Neuromuscular group based in Cambridge, MA and help drive translational biology drug discovery efforts with an emphasis on muscle biology . This is an opportunity for a scientific leader to advance portfolio projects...PrincipalSeniorLocal area
- ..., immunology, and biologics drug discovery and development. About RA... ...Therapeutics is seeking an experienced Principal Scientist to help establish and... ...to multidisciplinary teams, senior leadership, and external... ...computational sciences, supporting AI/ML-enabled protein...PrincipalSeniorFull timeLocal area
$100k - $155k
Building on our founders’ Nobel-prize winning discoveries in RNA interference, Atalanta... ...highly skilled and motivated Associate Scientist/Senior associate Scientist to join the in vivo... ...pharmacology group to support Atalanta’s drug discovery programs. This individual will...PrincipalSeniorContract work- ...Therapeutics in Cambridge, MA seeks a senior data product architect to design and evolve AI-ready scientific data products supporting drug discovery and development. You will connect... ...and governance. You will partner with scientists, knowledge architects, AI engineers,...Principal
$84k - $112k
Senior / Principal Associate Scientist, Advanced Cell Engineering Company Overview Strand Therapeutics is a clinical... ...will be passionate about scientific discovery, undeterred by bold challenges, and... ...Aurora) flow cytometry to analyze drug discovery assay readouts. Handling...PrincipalSeniorFull time- SLS Services Limited is seeking an Associate Principal / Principal Computational Biologist to drive advanced analytics, AI, and biological insight in condensate... ...strategies across multi-omics to accelerate drug discovery. The role requires a PhD with deep experience...Principal
$126k - $234k
...Summary#LI-Hybrid Internal Title: Principal Scientist II or Senior Principal... ...antibody-xRNA conjugates, from discovery through clinical translation... ...QSP, and PBPK/PD) that link drug pharmacology, tissue biodistribution... ...modeling workflows (e.g., agentic AI).• Proactively seek...PrincipalSeniorFull time$146k - $236k
...harnessing recent advances in AI, machine learning, and data to... ...uncertainty behind Flagship’s drug development and investment decisions... ...teams, feeding field discoveries back as product requirements.... ...gaps associated with complex agentic work products. Responsibilities...PrincipalSenior- 1910 in Boston seeks an experienced computational chemist to lead drug discovery efforts. The ideal candidate will have a Ph.D. and extensive experience in quantum chemical methods and molecular dynamics simulations. This role involves collaboration across interdisciplinary...Senior
- 1910, based in Boston, is seeking a Computational Chemist to enhance drug discovery through innovative computational chemistry solutions. In this pivotal role, you will lead programs across various therapeutic modalities, ensuring collaboration with biology and medicinal...Senior
$190.8k - $300.3k
Job DescriptionThe Nonclinical Drug Safety (NDS) Therapeutic Area Leader (TAL) is a senior scientific leader responsible for advancing... ...with Program Coordinators, Discovery Preclinical Leaders, Compound Leaders, and scientists across NDS and/or Preclinical Development...PrincipalSeniorFull timeFor contractorsLocal areaFlexible hours$79k - $127.65k
...Translational Post Doctoral Researcher — Agentic AI for Neurodegeneration for a 2-year... ...reshaping how we build agentic AI systems for drug discovery and how we evaluate them. Traditional... ...reasoning. Evaluating whether an AI co‑scientist can synthesize across pathology,...Temporary workFixed term contractLocal areaRemote work$122.25k - $176.58k
Job Title: Principal Scientist, Systems and Disease BiologyLocation... ...and pioneer AI-powered workflows that... ...accelerate the path from discovery to patient impact. Ready... ...and deploying modern agentic analysis workflows to... ...decision points in the drug discovery process. Opportunities...PrincipalFull time$216k - $297k
...harnessing recent advances in AI, machine learning, and... ...machine learning scientists innovating on model architectures... ..., refinement, and agentic integration.Guide... ...action reasoning, target discovery, perturbation biology,... ...for-biology, AI-enabled drug discovery,...Principal$154.4k - $242.55k
...knowledge.Job DescriptionJoin Takeda as a The Senior/Principal Scientist, Analytical Cell Line Engineering and... .... Operating at the interface between Discovery, Global Biologics, Analytical... ...Openness to using digital, automation, and AI-enabled tools to improve data analysis...PrincipalSeniorMinimum wageTemporary workLocal areaShift work$185k - $240k
...molecular design across our discovery portfolio. As a member of a... ...chemists, machine learning scientists, structural biologists, biologists... ...The role is offered at the Principal or Senior Principal Scientist level;... ..., direct contributions to drug discovery programs through the...PrincipalSeniorWork at office2 days per week3 days per week- ...Description The Immunology Discovery Therapeutic Area is seeking... ...accomplished and experienced Scientist to lead the Immune Cell Depletion... ...knowledge of preclinical drug discovery spanning target discovery... ...direct reports, peers, and senior leadership Establish and...PrincipalSeniorFull timeWork experience placementLocal area
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