Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics
$117k - $201.25kJohnson & Johnson
Principal Scientist role in preclinical safety and translational sciences focused on pharmacokinetics and pharmacodynamics modeling. The position supports drug discovery and early clinical development through quantitative model-based analyses to inform candidate selection and dosing strategies.
Responsibilities
- Apply PK/PD modeling to inform project decisions across discovery through early clinical studies
- Develop physiologically-based and mechanistic modeling approaches to predict drug profiles
- Quantify exposure-response relationships for biomarkers, efficacy, and safety outcomes
- Guide experimental designs to generate the most informative data for modeling and analysis
- Contribute to organization-wide modeling and simulation strategies
Requirements
- PhD in Pharmacology, Engineering, Mathematics, Physics, or related field with 4+ years industry experience; or Master's degree with 6+ years experience
- Strong knowledge of pharmacokinetic and pharmacodynamic principles with PK/PD modeling experience
- Demonstrated mathematical modeling and simulation skills with peer-reviewed publications
- Excellent written and oral communication abilities
- Strong interpersonal and teamwork skills
- Experience guiding experimental design for modeling applications
Compensation: $117,000-$201,250 base
Vacancy posted 3 days ago
Similar jobs that could be interesting for youBased on the Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics in Spring House, PA vacancy
$255.8k - $402.7k
...a physician-scientist to join our group as a Principal Scientist (Clinical... ...Director) in Translational Medicine/... ...with basic science teams on specific... ...design of preclinical and clinical... ...1 studies of safety, tolerability, pharmacokinetics and pharmacodynamics, to Phase 2 studies...PrincipalFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift work$255.8k - $402.7k
...a physician-scientist to join our group as a Principal Scientist (Clinical... ...Director) in Translational Medicine/... ...with basic science teams on specific... ...design of preclinical and clinical... ...1 studies of safety, tolerability, pharmacokinetics and pharmacodynamics, to Phase 2 studies...PrincipalFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift work$260.3k - $409.7k
Job Description Translational Medicine is responsible for early clinical... ...with Discovery Sciences and late-stage Clinical Research... ...related conditions. The Principal Scientist (Clinical Director) must have... ...therapy programs from Preclinical Candidate approval through...PrincipalFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift work$173.2k - $272.6k
...DescriptionThe Pharmacokinetics, Dynamics, Metabolism... ...collaborative scientist for the Drug... ...DMPK) group. The Principal Scientist will be... ...pharmacokinetics/pharmacodynamics (PK/PD), and... ...metabolism and translation to guide clinical... ...Pharmaceutical Sciences, Pharmacology, Chemistry...PrincipalFull timeFor contractorsLocal areaFlexible hoursMerck Sharp & Dohme (MSD)
West Point, PA2 days ago- MSD Malaysia is seeking a Principal Scientist (Clinical Director) in Translational Medicine/Early Clinical Development for the Neuroscience therapeutic area in the US. The role requires a physician-scientist with neurology or psychiatry training and a strong translational...Principal
$190.8k - $300.3k
...Nonclinical Drug Safety (NDS)... ...Coordinators, Discovery Preclinical Leaders,... ...Compound Leaders, and scientists across NDS and/... ...affairs, translational medicine, clinical... ...risk assessments, science-based waiver... ...Technologies, Pharmacodynamics, Pharmacokinetics, Product Registrations...PrincipalFull timeFor contractorsLocal areaFlexible hoursMerck Sharp & Dohme (MSD)
West Point, PA3 days ago$109k - $174.8k
...Senior Scientist position focused on developing AI and... ...learning models for drug safety prediction across discovery, preclinical, clinical, and real-world... ...AI/ML solutions for translational safety prediction using... ...informatics, computer science, statistics, or related...$173.2k - $272.6k
...Merck seeks a Principal Scientist to lead biomarker strategy development across neuroscience drug development programs. The role involves designing translational and clinical biomarker approaches that inform clinical decisions from early through late-stage development,...Principal- ...Johnson & Johnson seeks a Principal Scientist to design an AI-reasoning platform for translational safety in drug discovery. The role focuses... ...data across discovery, preclinical, clinical, and real-world evidence... ...Ph.D. in AI/ML, computer science, machine learning, data...Principal
Johnson & Johnson
Spring House, PA4 days ago $82k - $92k
...Merck seeks a postdoctoral fellow in translational neuroscience to design and execute preclinical studies on neurodegenerative diseases using rodent models and... ...Ph.D. in Neuroscience, Pharmacology, Biomedical Sciences, or related field (current or by spring 2027) Hands...Merck
West Point, PA4 days ago$82k - $92k
...Description Postdoctoral Fellow, Translational Neuroscience Position... ...diseases through cutting‑edge preclinical and translational research.... ...candidate is a highly independent scientist who enjoys working at the... ..., pharmacology, and data science to generate scientific insights...For contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work- HireLifeScience is seeking an experienced Senior Scientist for its Infectious Disease and Vaccines group in West Point, PA. You will... ...antiviral strategies, focusing on HIV biology, immune responses, and translational research using in vitro and in vivo models. The role requires...
- ...and Vaccines research site in West Point, PA seeks a Senior Scientist to drive discovery and development of antiviral therapies, with... ...role requires strong virology background, experience with translational animal models, and a track record in immunoassay, molecular biology...
$190.8k - $300.3k
...Biostatistics and Research Decision Sciences), a distinguished department... ...division, quantitative scientists, in partnership with other... ...in the Clinical Safety Statistics (CSS) group develop... ...process, from discovery and preclinical research through Phase 1-3 clinical...PrincipalFor contractorsWork experience placementLocal areaRelocationVisa sponsorshipFlexible hoursShift work$117k - $201.25k
...Analytics & Computational Sciences Job Sub Function Data Science... ...for the role of "Principal Scientist - AI-Reasoning for Drug Discovery... ...platform to support Translational Safety decision making in drug discovery... ...data across Discovery, Preclinical, Clinical, and RWE domains...PrincipalLocal areaImmediate startWorldwideShift work$231.9k - $365k
...Research Laboratories nonclinical drug safety department at West Point, Pennsylvania... ...to join a highly collaborative team of scientists (12 anatomic pathologists, 3 clinical pathologists... ...toxicology, safety pharmacology, and translational teams to define mechanisms of toxicity,...PrincipalFull timeFor contractorsLocal areaMerck Sharp & Dohme (MSD)
West Point, PA5 days ago$79k - $127.65k
Position Johnson & Johnson Innovative Medicine is seeking a Translational Postdoctoral Researcher — Agentic AI for Neurodegeneration for... ...Intelligence team at J&J Innovative Medicine, you will work with AI scientists and translational teams across C‑BRAIN’s academic network to...Temporary workFixed term contractLocal areaRemote work$117k - $184.2k
Job DescriptionSenior Scientist - Exploratory Vaccines and Regulated... ...us in applying laboratory science, automation, and data-... ...and transfer readiness for preclinical and clinical samples.Develop... ...Research, Ligand Binding Assay, Pharmacokinetics, Pharmacology, Sample...Full timeFor contractorsLocal areaMerck Sharp & Dohme (MSD)
West Point, PA1 day ago- Role Principal Scientist in High-Content Imaging within Johnson & Johnson's Innovative Medicine division, focusing on advancing therapeutic... ...generate high-quality data, support data analysis pipelines, and translate imaging readouts into biological insights. Qualifications Ph...Principal
$82k - $92k
Job Description Postdoctoral Research Fellow - Vaccine Preclinical Development - Experimental Medicine Our company is a global health... ...across multidisciplinary teams spanning immunology, virology, and translational research Education Minimum Requirement Must currently hold a...For contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work$117k - $201.25k
...patients, whose insights fuel our science-based advancements.... ...Medicine is recruiting for a Principal Scientist, AI & Autonomous Discovery... ...systems for drug discovery and translational research that integrate... ...standards for AI governance, safety, observability, reliability...PrincipalFull timeTemporary workLocal areaRemote work$117k - $201.25k
...Function Data Analytics & Computational Sciences Job Sub Function Data Science Job... ...Johnson company, is recruiting for a Principal Scientist, R&D Data, Data Science & Artificial Intelligence... ...across the portfolio. This role helps translate emerging capabilities into practical...PrincipalTemporary workLocal areaRemote work$168k - $199k
...to ensure the highest level of patient safety oversight and data integrity, including... ...cross-functional stakeholders to ensure translation of the clinical developent strategy and... ...Masters Degree; or Bachelor degree in a Science related discipline. Advanced degree (MSc...PrincipalRelocation packageCSL
King of Prussia, PA9 days ago$231.9k - $365k
...A senior anatomic pathologist position at a research-intensive biopharmaceutical company's nonclinical safety department in Pennsylvania. The role involves leading toxicological pathology evaluations, interpreting drug safety data, and collaborating across cross-functional...Principal- ...Senior Principal Scientist position leading clinical research strategy and execution for oncology drugs across all development phases. Responsible... ...-functional teams on drug development projects Evaluate preclinical data and prepare regulatory submissions and clinical study...Principal
Merck
Upper Gwynedd, PA4 days ago - ...Development Job Sub Function Pharmacokinetics & Pharmacometrics... ...best talent for our Scientist, Trial Support... ...whose insights fuel our science-based advancements.... ...of pharmacokinetic/pharmacodynamics (PK/PD) research... ...Analytics & Reporting, Translational Research with BDDS,...Local areaRemote work
$190.8k - $300.3k
...Senior Principal Scientist leading nonclinical drug safety strategy for immunology programs at Merck. Responsible for overseeing development progression,... ...Collaborate with discovery, regulatory affairs, translational medicine, and clinical development functions to ensure...Principal- ...& Johnson Biologics Discovery in Spring House, PA seeks a Principal Scientist, Protein Purification, Team Lead to guide a multidisciplinary... ...antibodies, multispecifics, and other biologics for preclinical studies. You will set purification strategy, lead a team of...Principal
- ...& Johnson Biologics Discovery in Spring House, PA seeks a Principal Scientist, Protein Purification, Team Lead to guide a team delivering... ...purified antibodies, multispecifics, and other proteins for preclinical studies. You will set purification strategy, advance automation...Principal
$82k - $92k
...Postdoctoral research fellow position in vaccine preclinical development focused on herpesvirus biology and immune dysregulation. The... ...across multidisciplinary teams in immunology, virology, and translational research Requirements PhD in immunology, virology, systems...
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Principal Scientist, Preclinical Safety & Translational Sciences-Translational Pharmacokinetics/Pharmacodynamics. Be the first to apply!
Related searches
- cell culture scientist Spring House, PA
- analytical scientist Spring House, PA
- principal scientist Spring House, PA
- drug safety scientist Spring House, PA
- qc scientist Spring House, PA
- validation scientist Spring House, PA
- research scientist Spring House, PA
- application scientist Spring House, PA
- remote scientist Spring House, PA
- scientist Spring House, PA