Principal Scientist
Johnson & Johnson Innovative Medicine
Johnson & Johnson Innovative Medicine in San Diego, CA invites a Senior Principal Scientist to join our Neuropsychiatry Discovery team. You will lead major biological research efforts, shape strategy, and drive translational studies from concept to pipeline alignment, advancing treatments for brain disorders. The role requires a PhD with 10+ years in neuroscience or related fields, plus deep experience in drug discovery, neuropharmacology, and cross-functional collaboration in a global matrix #J-18808-Ljbffr Johnson & Johnson Innovative Medicine
- ...across oncology, hematology, and neuroscience. The Role We are seeking an exceptionally driven, discovery-minded Senior Scientist / Principal Scientist to lead mRNA molecule design and platform innovation. This role sits at the front end of our innovation engine:...PrincipalFull time
- ...Job Title: Principal Scientist, In Vitro Pharmacology Department: Pharmacology Reporting to: Senior Director, Pharmacology Location: San Diego, CA (Onsite) About Sirius Sirius is a clinical stage biotech company developing innovative siRNA therapies for...PrincipalFull time
- ...Job Title: Principal Scientist, In Vivo Pharmacology Department: Pharmacology Reporting to: Senior Director, Pharmacology Location: San Diego, CA (Onsite) About Sirius Sirius is a clinical stage biotech company developing innovative siRNA therapies for...PrincipalFull time
- Reference: 630468Posted: 2026-09-22Location: San Diego, CaliforniaCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** ResponsibilitiesContribute to the design, development, and optimization of LNP formulations for mRNA delivery, including...Principal
$120k - $198k
...Title: Senior Scientist / Principal Scientist, Bioprocess Sciences Location: San Diego Job Type: Full-Time About Us: We are an innovative, stealth-mode biotech focused on developing best-in-class delivery for in vivo gene editing. Job Summary: We are seeking...PrincipalFull time- The Principal Scientist, Translational Medicine will play an important role in our organization, leading and managing translational biomarker projects, assessing mechanism of action and PK/PD relationships and supporting the translation of drug discovery programs into the...PrincipalFull time
$137k - $235.75k
...pioneering the path from lab to life while championing patients every step of the way. Learn more at Purpose: The Senior Principal Scientist will be a key member of discovery project teams and interact closely with biology chemistry and other drug metabolism and...PrincipalFull timeLocal area$144.4k - $216.6k
...specific project needs, enabling capabilities that are not commercially available.We are seeking an experienced and innovative Principal Scientist with expertise in optical design, microscopy, and functional imaging to join our team. This role bridges the disciplines of...PrincipalFull timeSummer workFlexible hours- ...transformative therapies in oncology, autoimmune diseases, and beyond. ABOUT THE OPPORTUNITY We are seeking a highly motivated Senior Scientist to join our R&D Operations team and advance our next‑generation antibody therapeutics. This lab‑based role offers the chance to...PrincipalFull timeFlexible hours
$156.89k - $190.12k
...transforms the lives of patients, and the careers of those who do it.Position SummaryComputational Sciences is seeking an exceptional Principal Scientist to join our Small Molecule Computational Design team. Using computational chemistry, cheminformatics, and machine learning,...PrincipalHourly payFull timeSummer workLive inLocal areaRemote workFlexible hours$137k - $235.75k
...Senior Principal Scientist position in neuropsychiatry discovery research at Johnson & Johnson's San Diego location. Lead complex biological research projects supporting psychiatric disease drug development, driving cross-functional initiatives from strategy through execution...Principal- ...Principal Scientist, Medicinal ChemistryWe are seeking a highly motivated and accomplished medicinal chemistry leader to drive drug discovery programs from Hit-to-Lead through Development Candidate nomination. This individual will not only independently lead medicinal...PrincipalSummer holidayLocal area
$152k - $190k
...state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.Compensation Range: $152K - $190KLocationSan Diego HQEmployment TypeFull timeDepartmentScienceChemistryCompensationPrincipal Scientist$152K - $190KPrincipalFlexible hours- Janux Therapeutics, Inc. seeks a Principal Scientist to lead analytical and formulation development for biologics in immuno-oncology and autoimmune disease. You will supervise CDMOs, develop analytical methods, and oversee stability and regulatory activities. The role emphasizes...Principal
$144.4k - $216.6k
...Vertex Pharmaceuticals seeks a Principal Scientist to design and develop custom optical instruments for drug discovery. The role combines expertise in optical design, microscopy, and functional imaging with cross-disciplinary collaboration in a fast-paced applied physics...Principal- ...The Principal Scientist In Vivo Preclinical Development will play a key role in the pre-clinical team generating IND-enabling data for selection of targeted lipid nanoparticle (tLNP) drug development candidates for various indications including autoimmune disorders. The...PrincipalFull timeContract workLocal area
- ...Neurocrine Biosciences seeks a Senior Principal Scientist to lead peptide chemistry and API development strategy across the company's pipeline. This role requires deep expertise in peptide synthesis and process chemistry combined with CMC leadership to establish scalable...PrincipalFor contractors
$151.33k - $183.37k
...benefits. This is work that transforms the lives of patients, and the careers of those who do it.We are seeking an accomplished Principal Scientist to advance antibody engineering initiatives within the Therapeutic Discovery Sciences Department on the Protein Engineering...PrincipalHourly payFull timeSummer workLive inLocal areaRemote workFlexible hours- Associate Principal Scientist, Medicinal ChemistryWe are seeking an accomplished medicinal chemist and project leader to drive drug discovery programs from Hit-to-Lead through Development Candidate nomination. The individual will define and execute medicinal chemistry strategy...PrincipalSummer holidayLocal area
- ...for discovering and qualifying materials and precursors for advanced semiconductor manufacturing. We are hiring two computational scientists to leverage our physics-based simulation stack — from atomistic chemistry through process-scale behavior — to fuse it with...Principal
- ...Merck seeks an Associate Principal Scientist in Immunology Discovery to lead early-to-late stage drug discovery programs for inflammatory and autoimmune diseases. The role involves directing cross-functional teams, designing innovative research strategies, and advancing...Principal
- We are seeking a highly motivated and scientifically rigorous individual as a Senior Scientist, Principal Scientist, or Director of Translational Research to lead translational strategy and execution for our pipeline. This individual will be primarily responsible for identifying...PrincipalSummer holidayLocal area
$136.2k - $211.1k
...science.Your OpportunityWe are looking for a highly motivated Principal / Senior Principal Hydrogeologist with a demonstrated ability... ...multidisciplinary teams of hydrogeologists, geologists, engineers, and scientists.Experience managing major projects or client portfolios with...PrincipalFull timeContract workTemporary workPart timeCasual workLocal areaWorldwideFlexible hours$156.89k - $190.12k
...Bristol Myers Squibb seeks a Principal Scientist in Computational Sciences to lead small molecule design efforts combining structural modeling and machine learning. The role involves advancing discovery programs through computational chemistry and cheminformatics applied...Principal$156.9k - $214k
Who We Are Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed...Principal$71.25k - $187k
...medicines treating autoimmune diseases and related complications Position Overview: We are seeking a highly motivated and dedicated scientist with knowledge and experience of cellular and molecular biology, who also shares our passion to help patients live with higher...PrincipalFull timeH1bFlexible hours$142.4k - $224.1k
...address significant unmet medical needs. We are seeking anAssociate Principal Scientistwith strong background in Immunology and experience... ...with colleagues and provide mentorship to less experienced scientists to ensure a culture of scientific rigor, collaboration and...PrincipalFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift work$114k - $228k
...to work for diversity, working mothers, female executives, and scientists. The OpportunityThis position works out of our San Diego... ..., molecular-based solutions. Position OverviewThe Associate Principal Bioinformatics Scientist is self-driven, working on multiple projects...PrincipalWork at officeWorldwideShift workNight shift$137k - $235.75k
...Job Description The Neuropsychiatry Discovery department at Johnson & Johnson Innovative Medicine is recruiting for a Senior Principal Scientist, located in San Diego, CA, USA. Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel...PrincipalLocal areaImmediate start$165k - $185k
...Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025. Job Summary: The Principal Scientist, Chemical Development will successfully develop robust synthetic processes and deliver non-GMP & GMP material on multi-kilogram...PrincipalLocal area
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