Principal Scientist, Oligonucleotide Design & Chemistry
Genentech
Genentech's Therapeutic Modalities and Technologies group in Protein Sciences is seeking a Principal Scientist (Group Leader) to lead the design and synthesis of novel oligonucleotide modalities for drug discovery. You will guide a multidisciplinary team, mentor scientists, and shape portfolio strategy in a dynamic, on-site South San Francisco setting. The role emphasizes technical leadership, collaboration with biology teams, and rapid decision-making to accelerate research outcomes. #J-18808-Ljbffr Genentech
$143.2k - $266k
...Genentech is responsible for the design and generation of new... ...dynamic individual with extensive oligonucleotide experience to join our team as a Principal Scientist (Group Leader), and support our... ...expertise in oligonucleotide chemistry who thrives in a team-oriented...PrincipalFull timeLocal areaRelocation package- Role Lead and mentor the Oligonucleotide & Small Molecule CMC Analytical Development team, providing scientific leadership in analytical method... ...technical issues, and collaborate across discovery, process chemistry, quality, and regulatory teams. Manage external analytical...Principal
$150k - $180k
...Switch Therapeutics is seeking a talented Oligonucleotide in-vivo pharmacologist to join the... ...leaders and cross-functional biology and chemistry teams to prioritize in vivo experiments... ...stakeholders. May require the supervision of Scientist and RA colleague(s) responsible for...PrincipalFull time$177k - $235k
...Description:We are seeking an innovative Senior Scientist / Principal Scientist to bridge the gap between... ...and cutting-edge computational design. In this role, you will serve as the primary... ..., biophysics, computational chemistry, structural biology, or related discipline...Principal$110k - $138k
...development of generative AI models to design protein and antibody therapeutics,... ...Role Xaira Therapeutics is seeking a Principal Associate Scientist to join our Bioanalytical Sciences team... ...Biochemistry, Immunology, Analytical Chemistry, or a related field with 7+ years of...PrincipalFlexible hours$159k - $207k
...therapeutics to patients.We are seeking a Principal Scientist to join our Formulation & Drug... ...including Fc-enzyme fusion proteins, protein-oligonucleotide conjugates, and knob-in-hole multi-... ...Sciences, Biophysics, Analytical Chemistry,, or related scientific discipline and...PrincipalContract workLocal area$40 - $49 per hour
...creative, self-motivated, collaborative Scientist-II to join the Nucleic Acid Design and Discovery (NADD) team within... ...a candidate with experience in oligonucleotide discovery and synthesis to... ...candidate will join an interdisciplinary chemistry team working in RNAi biology...$147.8k - $274.4k
...Intelligence (AI) to assist our scientists in both pRED and gRED to... ...motivated and collaborative Senior/Principal Machine Learning Scientist to... ....In this role, you will:Design and apply predictive machine... ...physical or life sciences (e.g., Chemistry, Biology) with a strong...PrincipalFull timeLocal areaWorldwide$197k - $235k
...Position Description:Calico is seeking a Principal Scientist, Drug Metabolism and Pharmacokinetics... ...closely with project, biology, and chemistry leads to support and advance programmatic... ...CRO relationships, including study design, data analysis, and report writingOversee...Principal$201.3k - $373.8k
...Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more... ...antibody discovery—from target assessment and design optimization to developability... ...Computational Biology, Biophysics, Immunology, Chemistry, or Computer Science with significant...PrincipalFull timeLocal areaWorldwideShift work$150.7k - $279.9k
...fundamental biology. Our group designs constructs, purifies... ...interactions. We collaborate with scientists throughout the Research and... ...therapeutics.The OpportunityAs a Principal Scientist in Structural... ...), or related computational chemistry workflows.You have a demonstrated...PrincipalFull timeWork at officeLocal areaWorldwideRelocation package$197k - $230k
...scouting, and scale-up of organic molecules. In this role, you will design, optimize, and execute synthetic processes that enable... ...focused position requiring strong experimental skills, deep organic chemistry knowledge, and the ability to translate laboratory findings...PrincipalContract workShift work$168.6k - $313k
...experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development... .... You will lead the Medicinal Chemistry efforts for a highly integrated and... ...novel peptide therapeutics. Govern the design and synthesis of innovative peptides and...PrincipalLocal areaRelocation package- Genentech in South San Francisco, CA, invites a Principal Scientist in Structural Biology to lead cross-functional efforts integrating cryoEM... ...and ligand interactions. You will guide discovery teams, design constructs, and translate insights into drug discovery strategies...Principal
- Job Title: Scientist II - Oligonucleotide Discovery Workplace Type: On-site Employment Type: Contract on W2 Contract Duration: 12 Months (Possible... ..., oncology, and immunology while driving nucleic acid chemistry and oligonucleotide synthesis activities. Responsibilities...Contract workLocal area
- We are seeking a Scientist II to support oligonucleotide therapeutic discovery and development programs. This... ...on experience with oligonucleotide chemistry, automated synthesis platforms, and... ...activities. Contribute to experimental design, data interpretation, and...Full timeLocal area
- ...Assistance, Inc., (SGA), is searching for an Oligonucleotide Scientist II for a contract assignment with one... ...-II to join the Nucleic Acid Design and Discovery (NADD) team within ProteinSciences... ...will join an interdisciplinary chemistry team working in RNAi biology research...Contract work
- Scientist II (Oligonucleotide Synthesis) South San Francisco, United States | Posted on 09/09/2026 Our... ...therapeutic areas. Key Responsibilities Design and execute oligonucleotide synthesis... ...cross-functional teams to integrate chemistry and biology data. Maintain and...Long term contract
- Job Title : Oligonucleotide Scientist II Working Model : Fully on-site, South San Francisco, CA 94080 Working Days : Monday to Friday Duration... ...oligonucleotide therapeutics discovery, synthesis, and nucleic acid chemistry to support RNAi drug discovery programs. BS/MS degree in...Contract workLocal areaImmediate startMonday to Friday
- Genentech in South San Francisco seeks a Principal Scientist (Group Leader) to drive oligonucleotide modalities across drug-discovery programs. You will design, synthesize, purify, and characterize ASOs/siRNAs, mentor scientists, and partner with biology teams to enable...Principal
- Denali Therapeutics Inc in South San Francisco, CA, seeks a Principal Scientist to lead formulation and drug product development for a growing portfolio of protein biologics. You will design studies, establish shelf life, and support comparability across development stages...Principal
- ...Principal Computational Biologist Are you ready to own the strategy behind how Gordian... ...discussions that strengthen experimental design, and make time to connect over weekly team... ...with disease-area and experimental scientists as you are discussing computational models...PrincipalDay shift
$164k - $205k
...Principal Scientist, Protein Engineering South San Francisco, California, United States Xaira is an innovative biotech startup focused... ...company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of...PrincipalFlexible hours$194.1k - $305.6k
...accomplished and highly collaborative Senior Principal Scientist to provide scientific leadership... ..., bioanalytical, toxicology, chemistry, and program teams to enable data-driven... ...therapeutic platforms. Proven ability to design, interpret, and integrate in vitro and...PrincipalFull timeContract workFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work$159k - $207k
...founded on the collaboration of leading scientists, industry experts, and investors who... ...additional countries, we are seeking a Principal Scientist to join our Large Molecule Analytical... ...Minimum Qualifications BS/MS/PhD in Chemistry, Chemical Engineering, Analytical...PrincipalContract workLocal area$75 - $85 per hour
...We are seeking an experienced Senior Scientist with a proven record of sustained laboratory... ...analytical techniques. Independently design experiments, perform sample analysis... ...Qualifications ~ Requires a M.Sc. degree in chemistry with ~8 years of relevant research...Hourly payContract workH1bShift work- ...precision medicine oncology company in South San Francisco, is seeking a Principal Research Scientist in Medicinal Chemistry to lead discovery efforts and deliver clinical candidates. You will drive design, synthesis, and optimization of drug-like molecules within cross-...
- ...streamline R&D workflows, and enable scientists to model complex biological... ...the Role We are seeking a Principal/AD Medicinal Chemist to lead... ...deep expertise in medicinal chemistry, strategic thinking, and... ...chemist who can independently design and execute medicinal chemistry...PrincipalRemote workWork visaFlexible hours
$162k - $186k
Senior Scientist, Analytical Development and Quality Control - Early Phase Brisbane, CA Company... ..., the next frontier in innovative drug design aimed at improving treatment options for... ..., Preclinical, Supply Chain, Medicinal Chemistry, and DMPK Maintain and organize...Contract work- ...CLD) Innovation Group is seeking a Senior Scientist I to join a talented and collaborative... ...vector and the host cell — from experimental design through execution and data... ...Previous experience working in CMC (Chemistry, Manufacturing and Controls) to contribute...Full timeTemporary workLocal area
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