Executive Director, Head of Clinical Data Management

Company Background Revolution Medicines is a late‑stage clinical oncology company developing novel targeted therapies for patients with RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC‑6236), a RAS(ON) multi‑selective inhibitor; elironrasib (RMC‑6291), a RAS(ON) G12C‑selective inhibitor; zoldonrasib (RMC‑9805), a RAS(ON) G12D‑selective inhibitor; and RMC‑5127, a RAS(ON) G12V‑selective inhibitor, are currently in clinical development. The Opportunity Executive Director, Head of Clinical Data Management provides strategic, operational, and people leadership for the clinical data management function across the Development portfolio. This role is accountable for establishing scalable data management strategies, ensuring inspection‑ready execution, and delivering high‑quality, reliable clinical trial data that support decision‑making, regulatory submissions, and patient safety. Key Responsibilities Establish and execute the Clinical Data Management strategy to support a growing oncology portfolio from first‑in‑human through registration‑enabling studies. Build and scale a high‑performing Clinical Data Management organization capable of supporting increasing study complexity and portfolio expansion. Serve as the enterprise leader for clinical data quality, data governance, and inspection readiness. Partner with CDSAS Leadership Team to drive adoption of innovative technologies, automation, and modern data review methodologies to improve efficiency and accelerate decision‑making. Partner with Quantitative Science senior leaders to ensure data management strategies support program milestones and portfolio priorities. Strategic and Functional Leadership Partner with Translational Medicine and Clinical Science teams to support integrated analyses and biomarker‑driven development strategies. Collaborating with CDM pillar heads, ensure data collection strategies align with evolving scientific, regulatory, and business needs. Including establishing standards, processes, and governance frameworks to ensure consistency, compliance, and operational excellence. Organizational Leadership Recruit, mentor, and develop Clinical Data Management talent. Foster a culture of accountability, collaboration, innovation, and continuous improvement. Build organizational capabilities that support future growth while maintaining operational agility. Manage budgets, resource planning, and prioritization to meet portfolio timelines and business objectives. Required Skills, Experience and Education Bachelor’s degree in life sciences, health sciences, computer science, biostatistics, or a related field; advanced degree preferred. Typically 25+ years of experience in clinical data management within biotechnology, pharmaceutical, or CRO environments, including significant leadership experience. Deep knowledge of end‑to‑end clinical data management processes, EDC systems, data standards, medical coding, and study closeout activities. Demonstrated success leading global, cross‑functional teams and managing external partners in a regulated environment. Strong understanding of GCP, ICH, CDISC standards, and regulatory expectations for clinical data quality and submission readiness. Experience supporting complex or global clinical programs, including multiple therapeutic areas and development stages. Excellent communication, organizational, and executive stakeholder management skills. Ability to translate strategy into execution while balancing quality, speed, cost, and risk. Preferred Skills Hands‑on experience with risk‑based data review, centralized monitoring support, and modern data review tools. Familiarity with decentralized trial data flows, external data integrations, and data governance frameworks. Experience preparing teams and systems for audits, inspections, and regulatory submissions. Compensation The base pay salary range for this full‑time position for candidates working onsite at our headquarters in Redwood City, CA is $265,000–$331,000 USD. Equal Opportunity Employer Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, medical condition, and veteran status. Privacy Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact View email address on click.appcast.io. #J-18808-Ljbffr Revolution Medicines