Group Leader - Senior Director, Quantitative Pharmacology and Pharmacometrics - Oncology
$210.4k - $331.1kFull-time
Merck
Job Description We are seeking an accomplished scientific leader to join the Quantitative Pharmacology and Pharmacometrics - Oncology (QP2 Oncology) team as Senior Director, Group Leader . QP2 Oncology is part of the Global Clinical Development organization and has oversight of clinical pharmacology, mechanistic PK-PD modeling, and pharmacometrics for oncology programs from post-preclinical candidate (PCC) selection through registration. Senior Directors are recognized scientific thought leaders who develop and implement clinical pharmacology strategies with a focus of utilizing MIDD strategies to advance drug development. This would include translational PK/PD strategies, biomarker-driven dose selection approaches, pharmacometric modeling and other quantitative approaches (e.g. QSP, AI/ML) for key development and regulatory decisions. This role provides strategic leadership and scientific oversight across a significant portion of the oncology portfolio. The Senior Director, Group Leader will lead a team of QP2 scientists and serve as a key contributor to oncology program strategy by applying model-informed drug development (MIDD) approaches to support critical decisions. Reporting directly to the QP2 Oncology Executive Director, the individual will collaborate closely with the QP2 Oncology Leadership team and broader organization to ensure consistent, high-value quantitative pharmacology contributions throughout the oncology portfolio. The role requires strong collaboration with cross-functional partners, including Clinical Development, Translational Medicine, Biostatistics, and Regulatory, as well as alignment with preclinical partners to inform first-in-human and clinical development strategies. Primary Responsibilities: Strategic & Scientific Leadership
Clinical Development, Clinical Pharmacology, Communication, Cross-Functional Collaboration, Drug Development, Leadership, Oncology, Oncology Drug Development, Pharmacometrics, Regulatory Responses, Stakeholder Relationship Management, Team Management Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts The primary location for this posting is:
USA - New Jersey - Rahway Where required by law, the compensation range for this role is provided below. The salary range for the primary location of this role is:
$210,400.00 - $331,100.00 This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at . Additional location(s): Please note the salary range above applies to the Primary Location of the position. Where a role has other listed locations, different compensation guidelines may apply. You may find the salary ranges for additional locations below. If the salary range is not listed for the location you are applying to, our Talent Acquisition team will provide further information to you relevant to your location. Additional location(s) Compensation Information: San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.- Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
Yes Travel Requirements:
10% Flexible Work Arrangements:
Hybrid Shift:
Not Indicated Valid Driving License:
Yes Hazardous Material(s):
n/a Job Posting End Date:
10/19/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R412343
- Lead and shape quantitative pharmacology strategy across oncology programs to inform key development decisions (e.g., dose selection, trial design, go/no-go decisions)
- Develop and implement integrated MIDD strategies to support decision-making across development stages
- Ensure alignment of modeling strategies with regulatory expectations and business priorities
- Maintain a comprehensive understanding of global regulatory expectations for small molecules, biologics including new modalities such as ADCs and TCEs
- Lead, mentor, and develop a team of QP2 scientists, including performance management, hiring, retention, and talent development
- Provide scientific and operational oversight to team members, ensuring high-quality and timely deliverables
- Contribute to broader QP2 and Oncology leadership initiatives, including talent strategies and organizational priorities
- Identify and support resource planning and allocation in partnership with senior leadership
- Serve as QP2 lead on assigned programs and represent QP2 in cross-functional teams and governance forums
- Collaborate with Translational, Clinical, and Biostatistics teams to integrate quantitative insights into development strategies
- Partner with preclinical teams to ensure appropriate translation of nonclinical findings into clinical development plans
- Contribute to due diligence for business development and licensing opportunities
- Develop and contribute to regulatory strategies, including authoring and reviewing key documents (e.g., INDs, CSRs, CTD modules, NDA/BLA submissions)
- Ensure delivery of high-quality clinical pharmacology and pharmacometric analyses and reports
- Represent the company in interactions with regulatory agencies, scientific conferences, and external collaborations
- Ph.D. in pharmacokinetics/pharmacodynamics, pharmacometrics, mathematics, statistics/biostatistics, chemical/biomedical engineering, or related discipline with ≥10 years of relevant pharmaceutical industry experience
- Master's, PharmD, or equivalent degree with ≥15 years of relevant pharmaceutical industry experience, with a demonstrated record of increasing responsibility, independence, and leadership in similar roles.
- Educational background in-biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, mathematics, computational biology, or a related field
- Oncology therapeutic area or disease knowledge
- Demonstrated ability to lead an interdisciplinary team or taskforce, and/or to oversee the work of others-
- Extensive experience in developing quantitative strategies for impacting pipeline decisions, and drug development expertise
- Ability to influence regulatory strategies including prior experience independently authoring and defending regulatory filings for marketing authorization (NDA/MAA)-
- Record of ability to operate in an inclusive and high-performance work environment applying enterprise ways of working principles including fostering collaboration and driving results, while managing ambiguity-
- Relevant regulatory and quantitative pharmacology experience--
- Proficiency in written and verbal communication, interdisciplinary collaboration, and problem scoping and planning-
Clinical Development, Clinical Pharmacology, Communication, Cross-Functional Collaboration, Drug Development, Leadership, Oncology, Oncology Drug Development, Pharmacometrics, Regulatory Responses, Stakeholder Relationship Management, Team Management Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts The primary location for this posting is:
USA - New Jersey - Rahway Where required by law, the compensation range for this role is provided below. The salary range for the primary location of this role is:
$210,400.00 - $331,100.00 This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at . Additional location(s): Please note the salary range above applies to the Primary Location of the position. Where a role has other listed locations, different compensation guidelines may apply. You may find the salary ranges for additional locations below. If the salary range is not listed for the location you are applying to, our Talent Acquisition team will provide further information to you relevant to your location. Additional location(s) Compensation Information: San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.- Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
Yes Travel Requirements:
10% Flexible Work Arrangements:
Hybrid Shift:
Not Indicated Valid Driving License:
Yes Hazardous Material(s):
n/a Job Posting End Date:
10/19/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R412343
Vacancy posted 3 days ago
Similar jobs that could be interesting for youBased on the Group Leader - Senior Director, Quantitative Pharmacology and Pharmacometrics - Oncology in Rahway, NJ vacancy
$210.4k - $331.1k
...seeking an accomplished scientific leader to join the Quantitative Pharmacology and Pharmacometrics - Immuno-Oncology (QP2‑IO) team as Senior Director, Advanced Pharmacometrics. QP2‑IO is... ...collaborations, consortia, and industry working groups.Minimum EducationPh.D. in...SeniorFull timeFor contractorsLocal areaRemote workFlexible hoursMerck Sharp & Dohme (MSD)
Rahway, NJ4 days ago- ...Merck seeks a Senior Director and Group Leader for its Quantitative Pharmacology and Pharmacometrics oncology team. This scientific leadership role directs clinical pharmacology strategy, manages a team of quantitative scientists, and applies model-informed drug development...Senior
Merck
Rahway, NJ3 days ago $210.4k - $331.1k
...Merck seeks a Senior Director of Advanced Pharmacometrics to lead quantitative pharmacology strategy across its oncology portfolio. This scientific leader will oversee model-informed drug development initiatives, mentor quantitative scientists, and collaborate cross-functionally...SeniorRemote work- ...Associate Director role in quantitative pharmacology and pharmacometrics for immuno-oncology drug development. The position involves leading model-based analyses, regulatory... ...regulatory documents (INDs, CSRs, CTDs) and represent group at regulatory meetings Collaborate across...Suggested
Merck
Rahway, NJ10 days ago $156.9k - $247k
...global healthcare leader with a diversified... ...industry leader in immuno-oncology (IO) and vaccines... ...to join the Quantitative Pharmacology and Pharmacometrics - Immune/Oncology (... ...role of Associate Director QP2-IO team is part... ...within the QP2-IO Group will work closely with...SuggestedFull timeFor contractorsLocal areaRemote workWorldwideRelocationVisa sponsorshipFlexible hoursShift workMerck & Co.
Rahway, NJ3 days ago- ...Associate Director position in Quantitative Pharmacology and Pharmacometrics within a major biopharmaceutical company's cardiometabolic research pipeline. The role involves developing model-based drug development strategies, supporting cross-functional teams, and advancing...
Merck
Rahway, NJ10 days ago $156.9k - $247k
...Description The Associate Director is an expert mechanistic modeler and a quantitative drug developer who... ...scientific data in group settings.- - As an... ...sciences, pharmacometrics, mathematics, statistics... ..., Model Development, Pharmacology, Pharmacometrics, PKPD...Full timeFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work$156.9k - $247k
...Merck seeks an Associate Director in Quantitative Pharmacology and Pharmacometrics with expertise in mechanistic modeling for immunology drug development. The role involves independently designing and executing model-based analyses to inform translational research and...$156.9k - $247k
...Job Description The Quantitative Pharmacology and Pharmacometrics (QP2) Department within our Company's Research Laboratories in Rahway, NJ, and West... ..., collaborative, and scientifically driven Associate Director to help support our growing cardiometabolic pipelines...Full timeFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work$181.8k - $350k
...build a better working world. Senior Commercialization Architect, Associate Director The Senior Commercialization... ...~ Knowledge of qualitative and quantitative price setting and optimization techniques... ...Join us in our team-led and leader-enabled hybrid model. Our...SeniorSummer holidayFlexible hoursEY
Iselin, NJ4 days ago$132.23k - $176.31k
...ownership, deliver meaningful impact, and help shape the future of AI‑ready connectivity, join us today. The Role Lumen is seeking a Senior Lead Technical Program Manager to join the Network Architecture and Engineering organization. In this highly visible role, you will...SeniorFull timeTemporary workRemote workLumen
Elizabeth, NJ9 hours ago$210.4k - $331.1k
Job DescriptionRole Summary:The Global Senior Director Medical Affairs (GDMA) position resides... ...medical advisors, payers, and scientific leaders—to ensure strategic alignment and... ...therapeutic guideline committees, payers, public groups, government officials, medical...SeniorFull timeFor contractorsLocal areaFlexible hoursMerck Sharp & Dohme (MSD)
Rahway, NJ4 days ago$190.8k - $300.3k
...position resides within our company Value and Implementation (V&I) Oncology organization, which leads the execution of value evidence... ...inform healthcare decision making.- Under the guidance of a senior leader, the Principal Scientist will provide US and ex-US outcomes...Full timeFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift workMerck & Co.
Rahway, NJ2 days ago$282.2k
...Senior Principal Scientist position in breast cancer clinical research at a pharmaceutical company. Responsibilities include developing... ...studies, and collaborating across functional teams to advance oncology drug development. Responsibilities Evaluate preclinical...SeniorMerck
Rahway, NJ2 days ago$173.2k - $272.6k
...Summary:The Global Associate Director Medical Affairs (GADMA) has scientific... ...their network of scientific leaders and bring executional... ...guideline committees, payers, public groups, government officials,... ...Leadership, Medical Affairs, Oncology, Pharmaceutical Industry,...For contractorsLocal areaFlexible hoursMerck Sharp & Dohme (MSD)
Rahway, NJ7 days ago$156.9k - $247k
Job DescriptionAssociate Director, Oncology Insights and Engagement - INTThe... ...a team of Specialists and Senior Specialists (on-shore and off... ...cross-functional stakeholder groups across DHH and other parts... ...executive presence with senior leaders.Effective interpersonal...Full timeFor contractorsLocal areaFlexible hoursMerck Sharp & Dohme (MSD)
Rahway, NJ4 days ago- Vitalief is looking for a Senior Clinical Research Coordinator to manage a portfolio of oncology clinical trials in Newark, NJ. The role is full-time and requires at least 3 years of relevant experience to oversee multiple studies, ensuring compliance with protocols and...SeniorFull time
$282.2k
...company is a global health care leader with a diversified portfolio... ...expanding your career. The Senior Director (Sr. Principal Scientist) has... ...activities involving new or marketed oncology medicines. Our oncology... ...with a cross-functional group of experts in commercialization...SeniorFull timeFor contractorsLocal areaFlexible hoursMerck Sharp & Dohme (MSD)
Rahway, NJ5 days ago- Acrisure is seeking a Senior Account Manager to join our growing team. The Account Manager is the primary day-to-day contact for service needs for both external and internal customers, coordinating deliverables and ensuring accurate responses. This role requires subject...Senior
$129k - $203.1k
Job DescriptionAssociate Director, Global Oncology CommunicationsThe role of Associate... ...our company, a recognized leader in oncology, as a key... ...as a liaison to third party groups (including advocacy organizations... ...working with C-suite and senior level executivesBudget and...Full timeTemporary workFor contractorsWork at officeLocal areaRemote workWorldwideFlexible hoursMerck Sharp & Dohme (MSD)
Rahway, NJ5 days ago$344.68k
...Posting TitleAssociate Director for Clinical Research... ...clinical Disease Specific Groups, clinical research... ...quality and sophisticated oncology care to patients close... ..., clinical and basic pharmacology, and Phase 1 clinical... ...in New Jersey, and a leader in laboratory,...TraineeshipSeasonal workWork at officeWorldwideFlexible hoursRutgers, The State University of New Jersey
New Brunswick, NJ4 days ago$190.8k - $300.3k
.... We are seeking a Director, Strategic Forecasting... ...contributor and a team leader, and, together, will act... ...respective business area (oncology, pharma, or vaccines).-... ..., Associate Directors, Senior Specialists (... ...Experience leading diverse groups of work colleagues and...Full timeFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift workMerck & Co.
Rahway, NJ14 days ago$50 - $55 per hour
Senior Human Resources Manager Job Overview Contract: 5 month contract with possible extension. Pay Rate: $50 - $55 per hour on W2. Location: Onsite at the Linden, NJ facility. Seniority Level: Mid-Senior level. Employment Type: Contract. Responsibilities Strategic...SeniorHourly payContract workSeasonal workLocal area- WSA - Wonderful Sound for All is a global leader in the hearing aid industry. Together with our 12,000 colleagues in 130 countries, we... ...care, hearing centers and diagnostics locations. WSA is seeking a Senior Reward Manager, Americas , to help shape a more consistent,...SeniorLocal area
- ...Summary of Responsibilities The Gateway Development Commission (GDC) is seeking a Senior Director of Claims to lead the organization, tracking and resolution of all construction change orders, disputes and claims for the Hudson Tunnel Project. The successful candidate...SeniorFull timeContract workFor contractorsFor subcontractorWork at officeHome officeFlexible hoursShift work
Gateway Development Commission (GDC)
Newark, NJ9 hours ago $157.6k - $205.43k
...this role will own the end-to-end partnership strategy, build senior relationships across the ecosystem, and convert partnerships into... ...relationships with partner organizations, including alliance leaders, business leaders, and executive stakeholders. Drive joint go...SeniorHourly payFull timeWork at officeRelocationFlexible hoursAxtria - Ingenious Insights
Berkeley Heights, NJ3 days ago- Job ID: 22924296Reference Number: 24-00923Title: Go Lang Senior Developer LeadLocation: Iselin, NJ, 08830Posted Date: 2024-09-17Company: HAN StaffingGo Lang Senior Developer LeadSenior
HAN Staffing
Iselin, NJ4 days ago - ...? At Turtle, we’re redefining what it means to be an industry leader in electrical distribution, and we want you to be part of our exciting... ..., including for our internal customers: our employees. As a Senior HR Business Partner, you’ll play a critical role in shaping the...SeniorWork at officeLocal area
Turtle and Hughes
Clark, NJ22 days ago - ...Associate Director role leading global oncology marketing insights and analytics within Merck's commercial team. Develops data-driven strategic insights for oncology asset launches, orchestrates cross-functional analytics delivery, and may lead a small global team of analysts...
Merck
Rahway, NJ7 days ago $282.2k
...Job Description Senior Principal Scientist, Breast Cancer... ...investigational or marketed Oncology drugs. Plan clinical trials... ...closely with a cross-functional group of experts in commercialization... ...Assist the Senior/Executive Director in ensuring that appropriate...SeniorFull timeFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift workMerck & Co.
Rahway, NJ3 days ago
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Group Leader - Senior Director, Quantitative Pharmacology and Pharmacometrics - Oncology. Be the first to apply!
Related searches