Senior Technical Program Manager

Role Description

We have an exciting Sr. Technical Program Manager within the Product Management group. As a key member of the team, you will own and drive complex, multi-team technical programs that modernize core platforms, improve system reliability and enable scalable product delivery. This role is designed for a highly technical program manager who thrives in ambiguous, high dependency environments and consistently delivers predictable outcomes.

You will lead a portfolio of engineering programs spanning platform transformation, product delivery and operational excellence. Success in this role requires the ability to deeply understand the system architecture, proactively manage risks and dependencies, and influence product and technical stakeholders. You will serve as the connective tissue across engineering and product, ensuring alignment, execution rigor and transparency at various levels of the organization.

Primary Responsibilities

• Own and lead the full lifecycle of complex technical programs across engineering teams - from initial scoping to launch and post-launch measurement.
• Drive program milestones and execution criteria.
• Partner closely with engineering to understand system architecture, make technical tradeoffs, and manage risks beyond simple coordination.
• Identify, track and actively manage cross-team dependencies, ensuring alignment and removing blockers to maintain delivery timelines.
• Drive predictable execution by defining detailed project plans, tracking milestones, and proactively identifying and escalating program risks, constraints, and technical dependencies with clear tradeoff decisions.
• Facilitate technical discussions and leverage data/metrics to monitor program health.
• Guide teams throughout the product lifecycle, including release planning, launch coordination and post-launch support.
• Communicate program status, risks, decisions clearly to stakeholders at all levels.

Qualifications

• Minimum of 8 years of technical program management experience.
• Strong technical foundation (software, infrastructure, or systems) and ability to engage in technical discussions.
• Proven ability to lead complex cross-functional stakeholder programs with significant dependency managing and coordinating across multiple teams.
• Demonstrated ability to operate effectively and independently in ambiguous environments.
• Excellent communication.
• Track record of delivering complex programs with high reliability, visibility and predictable outcomes.

Requirements

• Remote USA
• Salary Range: $120,000 — $160,000 USD

Benefits

• Comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Free testing for Natera employees and their immediate families, in addition to fertility care benefits.
• Pregnancy and baby bonding leave.
• 401k benefits.
• Commuter benefits.
• Generous employee referral program.

Company Description

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.