Vice President/Senior Vice President, Genomics & Data Science

About Stoke:

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit

Position Purpose:

The VP/SVP, Genomics & Data Science, will serve as a key scientific and strategic leader responsible for integrated Computational, Genomics, and Data systems, Therapeutic Design, and essential support of Discovery, Translational Development, and Technology Innovation. This leader will also oversee the establishment and stewardship of cohesive scientific computation, molecular & genomic data generation, and high-dimensional data interpretation and representation across the R&D organization. Reporting to the Chief Scientific Officer, this executive will grow a high-impact, multi-disciplinary team advancing therapeutic understanding, and partner across the organization to drive therapeutic development and translation, as well as pursue novel and differentiated technologies and scientific opportunities. The ideal candidate will possess exceptional communication skills, and a proven ability to operate effectively within a complex matrix organization.

Key Responsibilities:

• Provide strategic and technical leadership across scientific computation, molecular & genomic functions, and therapeutic design, including organizational management and cross-functional engagement
• Mentor and grow high-performing, technical and scientific team, with an enterprise perspective to data generation and interpretation, collaboration, and efficient execution on priorities
• Champion and oversee scientific computation/AI innovation, including multi-dimensional analytics, data representation & visualization, target insights, integration of genetics and internal/external data, and fit-for-purpose systems
• Lead therapeutic design, including exploration of next-generation approaches
• Establish and drive targeted genomics and molecular assays, including high-throughput approaches, model systems, and biomarker strategies to support development programs at all stages
• Proactively identify external opportunities and collaborations to augment core capabilities
• Champion and represent computational and molecular technologies and capabilities to key internal and external stakeholders, including senior management, board and SAB, through presentation, and publication.

Required Skills & Experience:

• Minimum 12 years of progressing experience leading quantitatively focused and multidisciplinary teams in the pharmaceutical, biotechnology, or life sciences industry
• Proven track record building and leading high-performing integrated teams, developing talent, and balancing enterprise priorities across efficiency, risk, and innovation
• Extensive experience in computational sciences, bioinformatics, genomic technologies, and related fields – ideally in the context of genetic medicines and therapeutic development
• Ph.D. or equivalent in Computer Science, Genomics, Molecular Biology, or other related quantitative fields
• Proven track record of innovation, strategic thinking, strong problem-solving skills, cross-functional collaboration, data-driven decision making, and organizational skills
• Ability to build and sustain an inclusive, collaborative culture that supports innovation and continuous improvement
• Exceptional communication skills, both verbal and written, with a proven ability to distill technically complex topics to all audiences, present recommendations, and drive alignment with senior leadership and cross-functional stakeholders
• Ability to navigate and influence within a complex matrix organization

Location(s):

Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026.

Travel:

This position will require approximately 10% travel.

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $310,000-375,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

For more information, visit

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.