Remote Regional Business Director, (Midwest Region), Immunology

Zenas is a clinical-stage global biopharmaceutical company committed to becoming a leader in the development and commercialization of transformative therapies for patients with autoimmune diseases. Our core business strategy combines our experienced leadership team with a disciplined product candidate acquisition approach to identify, acquire and develop product candidates globally that we believe can provide superior clinical benefits to patients living with autoimmune diseases. Zenas is advancing two late-stage, potential franchise molecules, obexelimab and orelabrutinib. Obexelimab, Zenas’ lead product candidate, is a bifunctional monoclonal antibody designed to bind both CD19 and FcγRIIb, which are broadly present across B cell lineage, to inhibit the activity of cells that are implicated in many autoimmune diseases without depleting them. We believe that obexelimab’s unique mechanism of action and self-administered, subcutaneous injection regimen may broadly and effectively address the pathogenic role of B cell lineage in chronic autoimmune disease. Orelabrutinib is a potentially best-in-class, highly selective CNS-penetrant, oral, small molecule Bruton’s Tyrosine Kinase (BTK) inhibitor with the potential to address compartmentalized inflammation and disease progression in Multiple Sclerosis (MS). Zenas’ earlier stage programs include a preclinical, potentially best-in-class, oral, IL-17AA/AF inhibitor, and a preclinical, potentially best-in-class, oral, brain-penetrant, TYK2 inhibitor.

We are seeking top talent who share our commitment to patients and have a track record of success in acquiring, developing and commercializing products across the globe. Our colleagues have an opportunity to engage in a fast-paced learning environment and experience individual and organizational success as we work towards becoming a global immunology and autoimmune disease leader, while living our values of Transparency, Relationships, Urgency, Excellence and Innovation – TRUE Innovation !

Position Summary:

The Regional Business Director (RBD), Immunology, is a critical commercial leadership role responsible for driving sales performance, strategic execution, and customer engagement across a defined geographic region. This includes the design and implementation of business plans based upon strategic business analysis. This leader will manage, coach, and develop a team of high-performing Account Managers (AMs) to ensure exceptional performance in a competitive rare disease, specialty market. The RBD will collaborate cross-functionally to optimize field strategy, enhance customer experience, and support successful launches within the immunology portfolio. This position reports to the SVP, US Commercial Engagement and Access.

Key Responsibilities:

Regional Leadership & Team Management

• Hire, lead, develop, and inspire a team of Account Managers to achieve and exceed regional sales goals.


• Establish a high-performance culture focused on accountability, integrity, strategic execution, and professional development.


• Develop and implement performance plans to support AM skill growth, capability building, and succession planning.


• Conduct regular field rides and coaching sessions to model best practices and reinforce customer-centric engagement.


• Ensure compliance with all company policies, legal requirements, and industry standards in all field activities

Strategic Planning & Execution

• Translate national brand strategy into actionable regional business plans tailored to local markets, customer needs, and competitive dynamics.


• Leverage market data, customer insights, and analytics to identify opportunities and challenges and adjust strategies accordingly.


• Oversee pull-through of brand initiatives, launch plans, and disease-area priorities across the region.


• Partner with Marketing, Market Access, Medical Affairs and other internal stakeholders to ensure aligned compliant execution.

Customer & Market Engagement

• Establish and maintain relationships with key customers, including HCPs, administrators, and influential institutions across immunology.


• Support AMs in developing deeper customer insights and effective territory plans.


• Ensure customer needs and marketplace dynamics are communicated to inform strategy, planning, and resource allocation.

Cross-Functional Collaboration

• Collaborate closely with Medical Affairs, Market Access, Patient Services, and other functions to ensure coordinated, compliant customer engagement.


• Work with leadership to support congress activities, regional events, and speaker programs.


• Ensure alignment between regional goals and national commercial priorities.

Operational Excellence

• Manage regional budget effectively, including resource allocation, travel, and strategic investments.


• Report regional performance trends, strategic recommendations, and competitive insights to senior leadership.

Qualifications:

• Bachelor’s degree required; MBA or advanced degree preferred.


• 8+ years of pharmaceutical/biotech commercial experience, with a minimum of 3–5 years leading field sales teams.


• Experience in rheumatology, immunology, rare disease, biologics, or specialty care strongly preferred.


• Demonstrated success in building, managing, and leading dynamic teams, including performance planning and skill development.


• Proven track record of strong sales performance in highly competitive specialty markets.


• Strong understanding of payer dynamics, specialty pharmacy distribution models, and access challenges in immunology/biologics.


• Excellent strategic thinking, business planning, and analytical skills.


• Exceptional communication, coaching, and interpersonal leadership abilities.


• Ability to travel extensively across the region.


• Talent Developer: Proven ability to coach, elevate, and retain high-potential talent.


• Strategic Operator: Strong business acumen with the ability to translate insights into actionable strategies.


• Cross-Functional Influencer: Effective at aligning multiple internal stakeholders toward shared objectives.


• Customer-Focused Leader: Deep commitment to understanding and addressing customer needs in immunology.


• Integrity & Compliance: Models ethical behavior and ensures compliant execution across the region.


• The preferred candidate will reside in the Chicago or Detroit area

#LI-Remote

The position is eligible for a competitive compensation and benefits package.

Zenas is committed to fair and equitable compensation practices. The base salary pay range for this role is $187,200 to $234,000. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.

Zenas believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Zenas’ competitive total rewards strategy that also includes annual performance bonus, equity, full range of benefits and other incentive compensation plans.

Zenas BioPharma is proud to be an equal opportunity employer. We are committed to fostering an environment where diversity is valued. All qualified applicants will receive consideration for employment based on merit, qualifications and the needs of the business.