Average salary: $150,200 /yearly

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  •  ...Team This role work closely with a Senior Machine Learning Scientist and our Lead Machine Learning Infrastructure Engineer, alongside...  ...and collaboration with teams closest to the customer. As a Principal-level IC, you'll have real input into technical direction — not... 
    Principal

    Gather AI

    Pittsburgh, PA
    3 days ago
  • $132k - $193.6k

    A leading global healthcare firm is looking for a Scientist/Senior Principal Scientist in Indianapolis to support small molecule therapeutics. The role involves developing bioanalytical methods, conducting metabolite identification, and mentoring junior scientists. Candidates... 
    Principal

    Eli Lilly and Company

    Indianapolis, IN
    2 days ago
  • A global healthcare leader is seeking a Senior Principal Scientist in Alzey, Germany, to support technical transfer for injectable drug production. The ideal candidate will bring over five years of experience in the industry, strong project management skills, and knowledge... 
    Principal

    Eli Lilly and Company

    New Bremen, OH
    2 days ago
  • A global healthcare leader is seeking a Senior Principal Scientist in South San Francisco to support drug discovery initiatives. The role requires planning and implementing experiments using in vitro assays and technologies, alongside a strong focus on generating high-quality... 
    Principal

    Eli Lilly and Company

    San Francisco, CA
    1 day ago
  • A leading biopharma company in Cambridge, MA is seeking a Senior Principal Scientist I to lead the development and validation of complex biomarker assays. This role requires extensive expertise in flow cytometry and assay design, along with proven leadership skills. The... 
    Principal

    BioSpace

    Cambridge, MA
    2 days ago
  • A leading biotechnology company in Bedford, Massachusetts, is seeking a (Senior) Principal Scientist in Cell Therapy. This hands-on role involves significant leadership in cell therapy discovery and development, advancing programs from early discovery to IND-enabling studies... 
    Principal

    PharmaEssentia U.S.A.

    Bedford, MA
    18 hours ago
  • A leading biopharmaceutical company located in South San Francisco is looking for a Senior Scientist or Principal Scientist to join their Synthetic Molecule Analytical Chemistry group. The role requires a PhD in relevant sciences with industry experience and a proven track... 
    Principal
    Relocation package

    Genentech

    South San Francisco, CA
    3 days ago
  • A leading healthcare institution in Boston seeks a Sr. Principal Scientist to oversee operations in a GMP lab, focusing on the production and quality control of radiopharmaceuticals. The ideal candidate will have extensive experience in aseptic operations, knowledge of... 
    Principal

    The University of Texas MD Anderson Cancer Center

    Boston, MA
    4 days ago
  • $64.5k - $167.2k

    A leading pharmaceutical company in Indianapolis is seeking a Senior Principle Scientist for its External Manufacturing Organization. This role focuses on overseeing Small Molecule manufacturing processes, ensuring compliance with regulatory standards, and providing technical... 
    Principal

    Eli Lilly and Company

    Indianapolis, IN
    18 hours ago
  • A leading pharmaceutical company is seeking an Associate Principal Scientist in Rahway, New Jersey. This role involves developing and qualifying analytical methods for Biologics drug products, requiring extensive experience in chromatography and molecular biology. The ideal... 
    Principal

    MSD Malaysia

    Rahway, NJ
    18 hours ago
  • A leading biotechnology company in South San Francisco is seeking a senior computational scientist to pioneer peptide therapeutic discovery. The role demands expertise in computational chemistry and machine learning to enhance our drug discovery pipelines. Responsibilities... 
    Principal
    Relocation package

    Genentech

    South San Francisco, CA
    4 days ago
  • A leading biotechnology company in New York City is seeking experienced machine learning scientists for its AI for Drug Discovery group. The role involves developing innovative models to transform drug discovery processes using various data sources. Candidates should have... 
    Principal

    Genentech

    New York, NY
    1 day ago
  • A leading semiconductor company is seeking a distinguished Sr. Principal GaN Scientist to shape its device technology roadmap. The ideal candidate must have a strong foundation in semiconductor physics and demonstrated experience in GaN technology. With 5-10 years of experience... 
    Principal

    Qorvo, Inc.

    Richardson, TX
    2 days ago
  • A global biopharmaceutical company is looking for a Senior Principal Scientist to join their Neuromuscular group in Cambridge, MA. The ideal candidate will lead drug discovery efforts focusing on muscle biology, oversee multiple projects, mentor junior scientists, and implement... 
    Principal
    Work at office
    Remote work

    UCB S.A.

    Cambridge, MA
    18 hours ago
  • $65.25k - $169.4k

    A leading global healthcare company is seeking a candidate for bioconjugation process development in Indianapolis. The ideal applicant will have extensive experience in synthetic organic chemistry or biochemistry, focusing on the development of bioconjugates. Responsibilities...
    Principal

    Eli Lilly and Company

    Indianapolis, IN
    1 day ago
  • A biopharmaceutical company is seeking a Principal Scientist in Toxicology & Pharmacology located in Sacramento, California. This role involves leading nonclinical safety strategies and collaborating on pharmacology studies to guide therapeutic design. Candidates must have... 
    Principal

    Crains Cleveland

    Sacramento, CA
    18 hours ago
  • $137.6k - $180.6k

    A biotechnology company is seeking a Principal Scientist to lead projects in muscle biology and translational drug discovery. Located in Cambridge, MA, this hybrid role involves overseeing research efforts and mentoring junior scientists while ensuring innovative methodologies... 
    Principal

    UCB S.A.

    Cambridge, MA
    18 hours ago
  • A leading biotechnology firm in Cambridge, Massachusetts, is seeking a Principal Scientist Liver to lead the liver portfolio. This role involves driving the discovery and development of novel RNA-based drug candidates for chronic liver diseases. Successful applicants will... 
    Principal

    ProQR Therapeutics N.V.

    Cambridge, MA
    3 days ago
  • A leading global company in Cambridge is seeking a Senior Scientist to advance lipid-based formulations for nucleic acid therapeutics. This role involves designing non-viral vectors, conducting in vitro experiments, and mentoring junior scientists. Ideal candidates have... 
    Principal
    Flexible hours

    Evonik

    Cambridge, MA
    18 hours ago
  • $136.8k - $189.2k

     ...Job Title: Sr. Principal Scientist Job Number: 37086 Location: Boston, MA Job Description The role will be responsible for all operations involved with routine manufacturing and quality control testing of radiopharmaceuticals produced in Aktis’ GMP laboratory... 
    Principal

    The University of Texas MD Anderson Cancer Center

    Boston, MA
    4 days ago
  • A global biopharmaceutical company is seeking a Senior Principal Scientist to lead drug discovery efforts in muscle biology. The position emphasizes supervising junior scientists, managing projects, and advancing translational research. Candidates should possess a PhD with... 
    Principal
    Work at office
    Remote work

    UCB

    Cambridge, MA
    1 day ago
  • A biotechnology startup in Watertown, MA is seeking a talented Senior/Principal Scientist to lead the RNA Production Research Optimization team. This role involves the development of in-vitro transcription conditions for circular RNA therapeutics and requires extensive... 
    Principal

    Orna Therapeutics

    Watertown, MA
    2 days ago
  • A leading biotech company based in California seeks a Principal Scientist for their Immunogenicity Bioanalytical Sciences group. The role involves designing and validating assays for detecting drug antibodies, collaborating closely with R&D and regulatory teams. Ideal candidates... 
    Principal

    Amgen SA

    Thousand Oaks, CA
    2 days ago
  • A prominent biopharmaceutical firm in Cambridge is looking for a scientific leader to provide technical oversight in in vitro selection and cell-surface screening for viral and bacterial antigens. Candidates should have a PhD and at least 5 years of relevant industry experience...
    Principal

    Moderna Therapeutics

    Cambridge, MA
    4 days ago
  • $220k - $270k

    A biotechnology company is seeking a Principal or Senior Principal Scientist in Protein Drug Discovery to lead the strategy and drive discovery programs in metabolic disease. The successful candidate will have a PhD and 6+ years of experience, with expertise in protein... 
    Principal

    Zealand Pharma group

    Cambridge, MA
    18 hours ago
  • A global biotechnology company is seeking a Senior Scientist/Principal Scientist in Quantitative Pharmacology to lead modeling efforts for gene and cell therapy products. Ideal candidates should have over 7 years of experience in quantitative pharmacology and a strong background... 
    Principal
    Permanent employment

    Legend Biotech USA

    Trenton, NJ
    2 days ago
  • A biotech startup is seeking a Senior/Principal Scientist to lead the development of next-gen RNA therapeutics. Responsibilities include optimizing IVT conditions and purification processes for circular RNA. Ideal candidates should possess a PhD with extensive experience... 
    Principal

    Orna Therapeutics, Inc.

    Oklahoma City, OK
    1 day ago
  • A leading contract research organization is seeking a Principal Scientist in Kansas City. The role involves expertise in quantifying proteins and anti-drug antibodies, providing oversight in early drug discovery and clinical studies. Candidates should have at least six... 
    Principal
    Contract work

    Kcas, Llc

    Kansas City, MO
    18 hours ago
  • A global biopharmaceutical company is looking for a Principal Scientist in Innovation Management. The role involves the development of upstream processes, oversight of biopharmaceutical production, and integration of digital tools in manufacturing. Candidates must have... 
    Principal

    Boehringer Ingelheim GmbH

    Fremont, CA
    2 days ago
  • A leading automation company seeks a Principal Applied Scientist in Bellevue, WA. The role involves defining technical strategies for agent-based automation, deploying ML systems, and mentoring teams in cutting-edge AI technologies. The ideal candidate has an advanced degree... 
    Principal

    UiPath

    Bellevue, WA
    18 hours ago