Senior Research & Development Fellow

Onyx is building a virtual immune system for faster and safer development of precision medicines. Our research generates rich, longitudinal multiomics data anchored in clinical context, enabling us to deeply profile the evolution of dysfunctional and healthy immune systems.

Onyx Bio — Berkeley, CA (On-site)
Onyx is building a virtual immune system for faster and safer development of precision medicines. Our research generates rich, longitudinal multiomics data anchored in clinical context, enabling us to deeply profile the evolution of dysfunctional and healthy immune systems. At our core, we believe that high-quality biological data is the cornerstone of scientific advancement. Join us in unraveling the intricacies of biology and ushering life sciences into the AI era. Together, we will tackle immune-related diseases that once seemed intractable—and improve the lives of millions worldwide.

We are seeking a Senior Research Associate to be the hands-on engine of our wet lab. You will work alongside two senior teammates—one leading R&D and assay development, the other leading platform/operations—providing the precise, reliable execution that turns precious patient samples into clean, reproducible multiomics data. In practice, you will work across our entire operation depending on need and priority: you’ll be supporting our sample collection kit/biobanking operations at times, and also running single-cell genomics and multiomics assays to support data generation at other times. It's a wear-many-hats role—on a given day you might load a 10x chip in the morning and pack a dry-ice shipment in the afternoon—so we're looking for someone whose defining trait is precision and attention to detail at the bench, paired with initiative and ability to identify the most pressing needs to support on a day to day basis. As you grow, this role will deepen into assay development and lab automation.

Data generation

Run single-cell genomics workflows end-to-end: PBMC thaw and prep, 10x Chromium chip loading, library construction, and QC.

Prepare and ship samples for external multiomics assays (proteomics, metabolomics); manage vendor handoffs, turnaround, and data return.

own the quality and reproducibility of the data you generate.

Kit platform and operations

Assemble, QC, and ship biosample collection kits for mobile phlebotomy and clinical research sites.

Collaborate with the Clinical Research team to coordinate shipping logistics for kits for member study visits

Manage inventory and procurement: reorder points, purchasing, receiving, vendor relationships, and qualifying new suppliers.

Support day-to-day lab readiness: equipment upkeep, consumables, freezer and inventory maps, and BSL-2 safety/PPE compliance.

As you develop: take on greater assay-development responsibility, and help design and program automated liquid-handling workflows.

BS or MS in molecular biology, biochemistry, immunology, bioengineering, or a related field, plus 3-5+ years of hands‑on wet‑lab experience.

Hands‑on experience with core molecular biology techniques (nucleic acid extraction, PCR, library prep, QC).

Hands‑on experience with single‑cell platforms (10x Genomics Chromium; Strong organization, reliable follow‑through, and documentation discipline—you can own logistics and inventory without dropping balls.

Comfortable wearing many hats and moving fluidly between several high priority tasks across bench science and hands‑on operations.

Able to work on‑site in a BSL-2 lab handling human biospecimens.

NGS library preparation and QC (TapeStation/Bioanalyzer, Qubit).

Flow cytometry and cell sorting for single‑cell preparation.

Cold-chain shipping experience and/or IATA/DOT dangerous‑goods certification (or willingness to obtain it).

Basic data/computational literacy (Python or R) a plus.

Competitive salary ($100k - $130k) and meaningful equity. Comprehensive health, dental, and vision insurance

Flexible PTO policy

We celebrate diversity and are committed to creating an inclusive environment for all employees. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

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