Chemistry Laboratory: Research Chemist

Scientist, Research and Development Division SSF Discovery Chemistry - ADC Bioconjugation
Our company’s Research Laboratories at South San Francisco are a multidisciplinary discovery site that offers state-of-the-art resources for exploring promising science, combining world-class chemistry and biologics research. Located in the heart of the Bay Area’s biomedical community, research here spans exploratory biology to early clinical development and is integral to our global drug and vaccine discovery network.

At our company, we believe a research‑driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee builds on our proud legacy of scientific breakthroughs, and we create a culture rooted in invention, respect, and collaboration.

We are seeking highly motivated and exceptional chemists to join the Discovery Chemistry Department at our South San Francisco, CA site. The successful candidate will contribute to multidisciplinary, collaborative discovery teams focused on inventing novel medicines through innovative synthetic chemistry, ADC bioconjugation, analytical characterization, and data‑driven design. Candidates should possess strong interpersonal, collaboration, and communication skills, and a proven record of solving complex scientific problems. Perform bioconjugations of linker‑payload combinations to antibodies, optimizing in‑house methods, including site‑specific conjugations for preclinical in vitro and in vivo studies.

Develop and optimize novel antibody‑drug conjugation strategies, including site‑specific approaches.

Design, execute, and optimize synthetic routes to access assigned target molecules using modern synthetic chemistry techniques.

Select and apply appropriate purification techniques for small molecules, including flash chromatography, high‑performance liquid chromatography (HPLC), and recrystallization, and for biologics purification methods such as SEC, hydrophobic interaction chromatography, and ion exchange chromatography.

Acquire, analyze, and interpret analytical data, including LC/MS, NMR, and related characterization methods.

Use available datasets and in silico tools to generate novel, testable hypotheses and design target molecules that enable clear decision‑making.

S. or equivalent degree in chemistry, biochemistry, or a related field with 5+ years of industrial or academic research experience, or a Master’s degree in chemistry, biochemistry, or a related field with 2+ years of industrial or academic research experience.

Knowledge of and experience interpreting biological activity data, including structure‑activity relationships.

Analytical Characterization, Antibody Drug Conjugates (ADC), Chromatography, Collaborative Communications, Detail‑Oriented, Liquid Chromatography‑Mass Spectrometry (LC‑MS), Purification Methods.

US and Puerto Rico Residents Only
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that showcases their true capabilities. Please request an accommodation during the application or hiring process if required.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.An employee’s position within the range will be based on relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

We offer a comprehensive package of benefits, including medical, dental, vision, other insurance benefits for employees and families, retirement benefits (401(k)), paid holidays, vacation, and compassionate and sick days. You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only
Los Angeles Residents Only
We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.

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Relocation
Domestic

VISA Sponsorship
Travel Requirements
Flexible Work Arrangements
Shift
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