Senior Director, Oncology Small Molecule
$194.1k - $305.6kFull-time
Merck
Job Description Discovery Oncology is seeking a visionary and strategic leader to shape and drive the discovery and advancement of the next generation of our Company's Oncology small molecule therapeutics. Come join an incredible team steeped in a history of scientific excellence and successful drug discovery. - The successful candidate will lead a team at our company's Boston site delivering on the small molecule Oncology pipeline. They will be the strategic leader for Oncology small molecule therapeutics in Boston, with opportunities to contribute across additional modalities. They will develop and execute a comprehensive pipeline strategy, partnering across our company to expand our portfolio. This leader will work tightly with chemistry, clinical, translational, and business development to build and progress an effective pipeline of compelling medicines, from discovery through late-stage development. The successful candidate will have a strong record of scientific excellence, thoughtful strategic planning, late-stage research and IND experience, and inspiring people leadership. - Responsibilities -
Cancer Research, Drug Development, External Collaboration, High Performance Team Building, Immunotherapy, IND Submission, Innovation, Investigational New Drug (IND), Motivation Management, Multidisciplinary Collaboration, Oncology, People Leadership, Program Leadership, Project Leadership, Small Molecules, Strategic Management, Strategic Planning Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts The salary range for this role is
$194,100.00 - $305,600.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at . You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.- Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
Yes Travel Requirements:
10% Flexible Work Arrangements:
Not Applicable Shift:
Not Indicated Valid Driving License:
No Hazardous Material(s):
n/a Job Posting End Date:
11/2/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R410076
- Develop and execute a forward-thinking pipeline strategy , shaping the future of our Company's Oncology therapeutics with a focus on small molecules. -
- Be a strategic thought leader for the employment of small molecules to create effective, tolerable, and combinable medicines that are both first-in-class and best-in-class. -
- Leverage your deep understanding of cancer biology (including intrinsic pathways and key cancer drivers) and the current internal and external oncology landscape to evaluate the opportunity of new therapeutics and drive portfolio decisions. -
- Provide strategic oversight for programs as they transition from early discovery into and through late-stage clinical development, ensuring continuity and alignment with the overall asset strategy. -
- Drive key milestones for pipeline advancement , from preclinical candidate selection through to IND-enabling studies and support for early clinical development. Ensure compelling engagement with regulatory agencies. -
- Lead business development evaluations from a scientific perspective, identifying and championing external assets and platforms that align with our strategic vision. -
- As a member of the Discovery Oncology Leadership team , meaningfully contribute to the development and execution of strategy and the growth and development of staff. Act as an experienced Program Lead and mentor others to become strong Program Leaders. -
- Foster a high-performance culture of collaboration, engagement, self-accountability, and inclusion. Establish strong relationships within highly collaborative, multidisciplinary teams to effectively drive drug discovery initiatives. -
- Ph.D. in Biology, Oncology, Pharmacology, Biochemistry, Toxicology, Biophysics, Immunology, or a related STEM subject area with 10+ years of post-degree experience in industry or equivalent. -
- An extensive background in cancer biology with a proven ability to translate deep scientific insights into drug development strategies from discovery through late-stage development. -
- Evidence of innovative approaches to small molecule design, particularly induced proximity. -
- A proven track record of successfully advancing multiple well-designed investigative small molecule drug candidates into the clinic, with a focus on patient experience and successful clinical execution. -
- Clear experience in late program leadership partnering with regulatory, translational sciences, and clinical development. Direct, hands-on experience writing IND modules and filings. -
- Experience managing a group of senior and junior scientists with a track record of achievements, including project leadership and strategic contributions. -
- Ability to build strong relationships within highly collaborative, multidisciplinary teams to effectively drive drug discovery initiatives. -
- Excellent attention to detail and strong communication (oral and written) skills. -
- Highly self-motivated and capable of prioritizing deliverables. -
- Preference will be given to candidates with a large breadth of small molecule experience, including novel approaches. -
- Experience with modalities beyond traditional small molecules is beneficial, particularly including small molecule payloads. -
Cancer Research, Drug Development, External Collaboration, High Performance Team Building, Immunotherapy, IND Submission, Innovation, Investigational New Drug (IND), Motivation Management, Multidisciplinary Collaboration, Oncology, People Leadership, Program Leadership, Project Leadership, Small Molecules, Strategic Management, Strategic Planning Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.--As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.- For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts The salary range for this role is
$194,100.00 - $305,600.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at . You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully-
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.- Employee Status:
Regular Relocation:
Domestic VISA Sponsorship:
Yes Travel Requirements:
10% Flexible Work Arrangements:
Not Applicable Shift:
Not Indicated Valid Driving License:
No Hazardous Material(s):
n/a Job Posting End Date:
11/2/2026
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R410076
Vacancy posted 6 days ago
Similar jobs that could be interesting for youBased on the Senior Director, Oncology Small Molecule in Boston, MA vacancy
- ...Merck's Discovery Oncology division seeks a Senior Director to lead small molecule therapeutic development at its Boston site. The role combines strategic pipeline oversight with scientific leadership, driving oncology programs from discovery through clinical development...Senior
Merck
Boston, MA5 days ago - ...Senior Director Oncology Small Molecules And Targeted Delivery Pathology Therapeutic Area Lead Join our dedicated Research & Development team in Biopharmaceuticals R&D as a Senior Director, Oncology Small Molecules and Targeted Delivery Pathology Therapeutic Area Lead...SeniorWork at officeFlexible hours3 days per week
- Lila Sciences in Cambridge, MA is looking for a Senior/Principal Scientist specializing in Small Molecule Therapeutics. This role focuses on leading hit identification through DNA-encoded libraries (DEL) and executing robust screening methodologies in collaboration with...Senior
$188k - $259k
About This Role We are seeking a highly motivated and creative Director of Chemistry to join our Small Molecule Chemical Development team. In this role, you will lead and mentor scientific and engineering teams as you guide project progression from early-phase through...SuggestedFull timeContract workTemporary workLocal areaBiogen Idec
Cambridge, MA3 days ago- ...Vertex Pharmaceuticals seeks a senior scientific leader to advance artificial intelligence and agentic systems in small-molecule drug discovery. This role bridges computational drug design, data science, and engineering to develop AI-enabled workflows that enhance molecular...Senior
Vertex Pharmaceuticals
Boston, MA6 days ago $168k - $252k
...generation, and decision-making. Although the primary focus will be small-molecule drug discovery, the successful candidate will also help extend... ...to influence scientists, engineers, data scientists, and senior leaders across a matrixed organization.Education and...SeniorFull timeSummer workRemote workFlexible hours2 days per week3 days per weekVertex Pharmaceuticals
Boston, MA4 days ago$188k - $259k
...Biogen seeks a Director of Chemistry to lead small molecule process development teams from early-stage through late-phase drug development in Cambridge, MA. The role involves designing and optimizing robust manufacturing processes, mentoring scientific and engineering...Biogen
Cambridge, MA6 days ago- Biogen, Inc. in Cambridge, MA, seeks a Director of Chemistry to lead the Small Molecule Chemical Development team, guiding projects from early-phase to clinical development and enabling scalable manufacturing of diverse drug candidates. You will mentor scientific and engineering...
$148k - $208k
Senior/Principal Scientist, Small Molecule Therapeutics Cambridge, MA USA The Senior/Principal Scientist, Small Molecule Therapeutics will lead early hit identification efforts, leveraging their expertise in DNA-encoded libraries (DEL) and complementary screening technologies...SeniorFull timeWork at officeLocal areaFlexible hours$120k - $180k
...Senior Scientist position focused on small molecule drug substance development at a pharmaceutical company. Responsibilities include managing technical transfers with contract manufacturers, conducting synthetic organic chemistry experiments across development stages,...SeniorContract workVertex Pharmaceuticals
Boston, MA6 days ago$126k - $181.5k
...with an ambitious and exciting mission: to unlock the future of small molecule drug discovery. FL129 is developing a revolutionary approach... ...Summary: We are seeking a motivated and highly collaborative Senior Scientist to join FL129’s growing team of experimental and computational...SeniorContract workSeres Therapeutics
Cambridge, MA1 day ago$136.8k - $167.2k
...to both technical and non-technical audiencesServe as the team process chemistry SME across the matrix for oligonucleotide and small molecule synthesis; mentor and train junior scientists; and collaborate with stakeholders that support other modalities.About You:Solid...SeniorFull timeIntellia Therapeutics
Cambridge, MA1 day ago$235k - $330k
...is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly... ...are valued, seen, and heard.How you’ll make an impact:The Senior Director, Outcomes, Value & Access will serve as Kymera’s strategic...SeniorKymera Therapeutics
Watertown, MA4 days ago- ...information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the Role: The Senior Director, Oncology Forecasting reports to the Vice President, Global Insights and Analytics and leads the global forecasting function for Takeda...SeniorMinimum wageLocal area
Takeda
Boston, MA1 day ago $237.9k - $356.9k
Job DescriptionGeneral Summary:The Senior Director, Immunology will oversee multiple research programs and initiatives that support the... ..., including cell and genetic therapies, biologics, small molecules, and nucleic acid-based medicines.Strong scientific judgment...SeniorFull timeSummer workFlexible hoursVertex Pharmaceuticals
Boston, MA5 days ago$176k - $294.3k
...science to create new therapeutic modalities beyond traditional small molecules. FL111 is backed by Flagship Pioneering, bringing the... ...our passion for impact to join us!THE ROLEFL111 is seeking a Director/Senior Director, Computational Chemistry to spearhead the design...SeniorFlexible hoursSeres Therapeutics
Somerville, MA4 days ago$212k - $333.19k
...designed to incubate the future AI-powered operating models for large molecule discovery and deliver candidates to the clinic at industry... ...experience of DMPK requirements for diverse modalities (e.g., small molecules, biotherapeutics).Responsibilities include directing...SeniorMinimum wageLocal areaTakeda
Boston, MA1 day ago$195k - $330k
...is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective... ...but not required with 10+ years of CMC experience; Sr. Director level requires commensurate additional experience and...SeniorKymera Therapeutics
Watertown, MA3 days ago$212k - $333.19k
...all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Senior Director, Oncology Search & Evaluation will be responsible for advancing the oncology portfolio through the integration of external...SeniorMinimum wageLocal areaRemote workTakeda
Cambridge, MA4 days ago- ...Senior Director, Medical Affairs, Hematologic Malignancies About the Company Mission-driven global biopharma advancing cutting-edge oncology therapies for high unmet needs. Industry Biotechnology Type Privately Held About the Role The Company is...Senior
$171.2k - $256.8k
...targets in cancer.This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and... ...Avenue, in the Fenway area of Boston, Massachusetts.SummaryThe Director, GCP & GLP QA, reporting to the Executive Director, Quality, is...SeniorContract workTango Therapeutics
Boston, MA4 days ago- ...Role Senior Director, Oncology Forecasting, leading Takeda Oncology's global portfolio forecasting across marketed products, launches, pipeline assets, and lifecycle opportunities. Responsibilities develop forecasting standards, oversee long-term portfolio...SeniorFull time
$161.4k - $201.84k
...advancing two late-stage, potential franchise molecules, obexelimab and orelabrutinib.... ..., highly selective CNS-penetrant, oral, small molecule Bruton’s Tyrosine Kinase (BTK)... ...Innovation!Position Summary:The Associate Director of Analytical Development and Quality Control...Zenas BioPharma
Waltham, MA2 days ago$218.33k - $327.49k
...Senior Director role leading competitive intelligence and strategic analysis for AstraZeneca's oncology research division. Responsible for delivering clinical and commercial insights to senior leadership that shape portfolio decisions and investment strategy across the...SeniorAstraZeneca
Cambridge, MA6 days ago$115k - $215k
...Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly... ...’ll make an impact:We are seeking an experienced Manager or Senior Manager of Patient Recruitment and Retention to lead our initiatives...SeniorLocal areaKymera Therapeutics
Watertown, MA3 days ago$145k - $240k
...first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in...SeniorContract workKymera Therapeutics
Watertown, MA4 days ago- ...Kymera Therapeutics seeks a Director or Senior Director to manage chemistry, manufacturing, and controls programs for mid-to-late-stage oral small molecule degrader candidates. The role encompasses timeline planning, cross-functional coordination, regulatory submission...Senior
Kymera Therapeutics
Watertown, MA6 days ago $150k - $225k
...breakthrough drugs to improve outcomes for patients through the creation of Gemini Digital Twins of human disease with a focus in oncology and neurodegenerative diseases. Aitia collaborates with pharmaceutical companies, academic medical centers, data partners, and patient...SeniorContract workPart timeWork at officeAitia
Cambridge, MAa month ago$202.4k - $323.4k
Director/Senior Director, Molecular Discovery Cambridge, MA USA; London, UK; San Francisco, CA USA The Director, Molecular Discovery... ...science platform reliably and repeatedly delivers validated small-molecule drug candidates against designated targets at increasing speed...SeniorFull timeWork at officeLocal areaFlexible hours$120k - $200k
The Opportunity:As the Senior Associate/Associate Director of Portfolio and Strategy Operations, you will help ensure flawless... ..., with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of...SeniorFlexible hoursRelay Therapeutics
Somerville, MA3 days ago
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Senior Director, Oncology Small Molecule. Be the first to apply!
Related searches
- ai director Boston, MA
- director work from home Boston, MA
- director of aviation Boston, MA
- director of admissions Boston, MA
- lifestyle director Boston, MA
- director medical information Boston, MA
- children's ministry director Boston, MA
- director talent management Boston, MA
- director of government affairs Boston, MA
- director of automation Boston, MA