Principal Scientist, Computational Biology-Oncology Translational Research

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.comAs guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.Job Function: Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function: Translational Discovery & Development BiomarkersJob Category:Scientific/TechnologyAll Job Posting Locations:Cambridge, Massachusetts, United States of America, La Jolla, California, United States of America, Spring House, Pennsylvania, United States of AmericaJob Description:About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at About Oncology Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at We are seeking a highly motivated principal scientist to join our translational research team based in Spring House, PA, Cambridge, MA, La Jolla, CA.Position SummaryThe Principal Scientist, Computational Biology-Oncology Translational Research, will be responsible for developing and executing computational strategy for oncology translational and clinical biomarker programs. This individual will lead the integration and interpretation of complex multimodal omics, biomarker, and clinical data; determine and defend fit-for-purpose analytical approaches; and deliver rigorous AI-enabled bioinformatics, statistical, and machine-learning evidence that meaningfully informs clinical development. The role requires broad oncology expertise, deep clinical-trial and pharmaceutical-development knowledge, and the scientific leadership to influence decisions across Translational Research, Clinical Development, Statistics, Programming, Pathology, Diagnostics, Data Science, Regulatory, and Biomarker Operations.Essential Job Duties and ResponsibilitiesLead computational hands-on analyses of multimodal oncology biomarker data, including DNA/RNA sequencing, proteomics, flow cytometry, single-cell, and spatial transcriptomics data; apply deep cancer biology knowledge to determine and defend analytical approaches and biological interpretation.Define and develop appropriate statistical and machine-learning plans to carry out biomarker and clinical-outcome analyses, with careful consideration of validation, bias, missingness, batch effects, and analytical limitations.Drive integration of molecular, pathological, assay, sample, and clinical data to establish the relevance, clinical utility, evidentiary strength, and limitations of pharmacodynamic, prognostic, predictive, and resistance biomarkers.Define and support computational evidence generation for biomarker plans, patient-selection and enrichment strategies, MRD initiatives, longitudinal monitoring, and clinical-study interpretation using deep knowledge of oncology drug development and trial design.Drive responsible adoption of approved AI-enabled methods, including multimodal and foundation-model approaches and agentic workflows; ensure human oversight, validation, traceability, reproducibility, data privacy, and scientific accountability.Collaborate with cross-functional study and program teams; make and defend computational recommendations; and contribute to publications, presentations, and evaluation of emerging computational and biomarker technologies.Required QualificationsPhD in Bioinformatics, Computational Biology, Biostatistics, Genomics, Data Science, or a related quantitative field, with at least 3 years of relevant pharmaceutical or biotechnology industry experience.Advanced proficiency in R, with experience in Python, Linux/Unix, shell scripting, version control, and reproducible analysis of high-throughput sequencing and multimodal omics data.Demonstrated scientific leadership in computational oncology, with deep knowledge of cancer biology, biomarker applications, oncology drug development, and the ability to facilitate major programs or study workstreams.Advanced statistical and machine-learning experience, including regression, multivariate data analysis, survival analysis, supervised learning, semi-supervised learning, unsupervised learning, reinforcement learning for the analysis of biomarker, assay, and clinical data.Deep working knowledge of IND and NME development and Phase 1–3 oncology trials, including dose escalation and expansion, randomization, stratification, analysis populations, clinical endpoints, censoring, longitudinal data, and treatment response.Ability to lead and influence across functions, communicate and defend complex analytical recommendations and limitations, mentor others, and demonstrate scientific impact through high-quality peer-reviewed publications and presentations.Preferred QualificationsDeep working knowledge of CDISC SDTM and ADaM data models, regulatory clinical data management practices, and biomarker-data traceability.Experience with deep learning, multimodal modeling, or responsible application of foundation models or agentic AI to biomedical research.Working knowledge of clinical-trial statistics approaching an effective partnership level with clinical statisticians, including survival and longitudinal models, multiplicity, missingness, treatment-effect heterogeneity, and external validation.Experience supporting patient-selection, companion or complementary diagnostic, regulatory, or submission-related biomarker activities.Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).This position is eligible to participate in the Company’s long-term incentive program.Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:Vacation –120 hours per calendar yearSick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar yearHoliday pay, including Floating Holidays –13 days per calendar yearWork, Personal and Family Time - up to 40 hours per calendar yearParental Leave – 480 hours within one year of the birth/adoption/foster care of a childBereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar yearCaregiver Leave – 80 hours in a 52-week rolling period10 daysVolunteer Leave – 32 hours per calendar yearMilitary Spouse Time-Off – 80 hours per calendar yearFor additional general information on Company benefits, please go to: - The anticipated base pay range for this position is: $115,000 to $227,000Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via , internal employees contact AskGS to be directed to your accommodation resource.#LI-HybridRequired Skills:Preferred Skills:Biomarkers, Clinical Trials Operations, Coaching, Critical Thinking, Drug Discovery Development, Industry Analysis, Interdisciplinary Work, Medical Compliance, Medical Technology, Organizational Project Management, Organizing, Program Management, Quality Standards, Safety-Oriented, Scientific Research, Technologically Savvy, Translational MedicineThe anticipated base pay range for this position is :$117,000.00 - $201,250.00Additional Description for Pay Transparency:SummaryLocation: Spring House, Pennsylvania, United States of America; Cambridge, Massachusetts, United States of America; La Jolla, California, United States of AmericaType: Full time