Senior Associate Scientist, Functional Genomics

Job Title Senior Associate Scientist, Functional Genomics Location Cambridge, MA About the Job We are seeking a highly motivated and creative scientist to join the Functional Genomics cluster within the Target, Disease, and Systems Biology function in Sanofi Research. The role will drive application of functional genomics target ID and validation to advanced disease models, elucidating disease mechanisms and discovering novel targets across immunology, ophthalmology, neurology, oncology, and rare disease. The successful candidate will collaborate closely with therapeutic area colleagues to advance functional genomics target discovery and validation and develop new screening workflows in advanced disease models including primary cells, iPSC-derived cells, and co‑culture/organoid systems. This is a unique opportunity to work at the intersection of functional genomics, in vitro modeling, and disease biology. Responsibilities Perform experiments including pooled and arrayed CRISPR screens in human cellular disease models to validate targets and understand mechanism of action. Collaborate with senior researchers to develop and execute existing and novel cell‑based assays to identify, validate, and translate high‑value targets in diverse clinical indications. Develop cellular and molecular assays to study disease processes and validate targets in innovative disease models such as primary or iPSC‑derived cells, co‑culture systems, or organoids. Innovate in functional genomics technology by refining, scaling, or automating experimental methodologies to systematically explore gene function in disease contexts. Collaborate closely with therapeutic area experts to advance target discovery and in‑vitro disease modeling. Communicate work verbally, in writing, and in presentations. Qualifications B.S. in biology or related field with a minimum of 5 years of industry experience. Hands‑on experience in CRISPR genome editing or screening and disease modeling, especially in primary cells. Preferred: experience in target or drug discovery in immunology, ophthalmology, or neurology. Experience with molecular and biochemical assays such as PCR/qRT‑PCR/NGS, western blot, and flow cytometry. Excellent communication, organizational, and team skills with a track record of success collaborating across disciplines. Benefits Competitive salary range: $75,000 – $108,333, commensurate with experience. Health and wellness benefits including high‑quality healthcare, prevention and wellness programs. At least 14 weeks’ gender‑neutral parental leave. Opportunities for career growth, promotion, and lateral movement, including international options. Access to cutting‑edge AI, data, and digital platforms for drug discovery. Equal Opportunity Employer Sanofi Inc. and its U.S. affiliates are Equal Opportunity and affirmative action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital status, sex (including gender identity and expression), sexual orientation, disability, veteran status, or any other characteristic protected by law. Location Restriction U.S. and Puerto Rico residents only. North America applicants only. #J-18808-Ljbffr Sanofi