Research Scientist I/II, Biology (Dual Posting)

Job Description Summary: This role is based in Cambridge, MA and does not have the ability to be located remotely. The Novartis BioMedical Research Oncology Disease Area is seeking an experienced scientist to join the Target Biology and Discovery (TBaD) group. The mission of our group is to uncover novel therapeutic targets and effective modalities to benefit cancer patients. By leveraging cutting‑edge technologies, innovative screening approaches, and in‑depth mechanistic studies, the team initiates the crucial first steps in bringing new oncology medicines to the clinic. Key Responsibilities Apply modern chemical genetics approaches to identify and validate novel targets and elucidate pathway dependencies in oncology programs. Develop and optimize cellular assays for compound identification and characterization, including degradation assays (HiBIT, Prolabel), protein‑protein interaction assays (NanoBIT), viability assays (CTG), and reporter‑gene systems. Support project teams by building assay capabilities to enable chemical tool development and early therapeutic discovery, while contributing to mechanistic studies. Leverage genome editing technologies (e.g., CRISPR-based tools) to perform genetic screens and investigate mechanism of action. Explore emerging therapeutic modalities, including targeted protein degradation and proximity‑inducing approaches, to address challenging targets. Collaborate cross‑functionally and externally to drive innovation and contribute to team culture and scientific excellence. Essential Requirements B.S. or M.S. in Biochemistry, Molecular Biology, Cell Biology, Chemical Biology, or a related field. Experience in cellular assay development, hit identification, and downstream characterization. Strong proficiency in mammalian cell culture, molecular biology techniques, and protein analysis workflows (e.g., Western blotting, FACS). Experience with CRISPR-based gene editing technologies (e.g., CRISPRi, CRISPRa, base editing, prime editing). Demonstrated ability to contribute to drug discovery efforts and collaborate effectively within matrixed teams. Strong communication, organizational, and interpersonal skills. Ability to manage multiple priorities and deliver high‑quality results. Scientific curiosity, problem‑solving capability, and commitment to improving patient outcomes. Role Leveling (Dual Posting) Research ScientistI: ~1‑3+ years of relevant industry experience in oncology, target validation, or drug discovery. Research ScientistII: ~6+ years of relevant industry experience in oncology, target validation, or drug discovery. Preferred Requirements Experience with automation systems for high‑throughput screening (384‑ and 1536‑well formats). Background in chemical biology, targeted protein degradation, induced proximity, or related modalities. Location & Working Model This role is based in Cambridge, MA and is onsite. Remote work is not available for this position. Compensation and Benefit Summary Research ScientistI: $92,800–$139,200. Research ScientistII: $102,400–$150,800. The final salary offered is determined based on relevant skills and experience, and will be reviewed periodically. Compensation includes performance‑based cash incentive and eligibility for annual equity awards. Eligible employees receive a comprehensive benefits package including health, life and disability benefits, a 401(k) with company contribution and match, and other benefits. A generous time‑off package including vacation, personal days, holidays and other leaves is also provided. EEO Statement The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. #J-18808-Ljbffr U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.