Principal Biologist

Responsibilities Design and execute cell-based pharmacology assays to evaluate proximity-inducing compounds (degraders, molecular glues, stabilizers) Manage CRO relationships for outsourced assays and run high-priority experiments in-house Characterize compound activity profiles: dose-response, kinetics, selectivity, mechanism of action, and SAR at the cellular level Build and validate disease-relevant cellular models (engineered cell lines, primary cells, co-culture systems) for target validation and translational pharmacology Develop and optimize quantitative assay readouts including high-content imaging, flow cytometry, reporter systems, and multiplexed approaches Collaborate with computational scientists and the XLMS platform team, providing biological feedback to improve ML model predictions and data generation priorities Prepare data packages for internal decision-making, BD/partnership discussions, and due diligence Requirements PhD in cell biology, pharmacology, molecular biology, or a related discipline 3–8 years of post-PhD experience in a biotech or pharma drug discovery environment, ideally in proximity biology, targeted protein degradation, or molecular glue programs Deep hands‑on expertise in designing and executing cell‑based pharmacology assays (degradation assays, ternary complex formation, ubiquitination, reporter systems) Experience with quantitative cellular techniques: high‑content imaging, flow cytometry, AlphaLISA/HTRF, NanoBRET, Western blot, ELISA, and/or proteomics‑based approaches (TMT, global proteomics) Track record of working at the interface of computational predictions and experimental validation Comfortable working in a fast‑paced, resource‑constrained environment where you own the experimental design end to end Strong scientific communication skills; able to present data clearly to computational and medicinal chemistry and biology audiences. #J-18808-Ljbffr Proxima