Senior Scientist, In Vivo Pharmacology

Stoke Therapeutics(Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered inBedford, Massachusetts. For more information, visit Position Purpose: The Senior Scientist will work collaboratively across the Research organization to support preclinical efforts in understanding the target engagement, pharmacology, and efficacy of novel compounds in disease models. This position requires a scientist with experience designing and executing thoughtful in vivo studies and developing assays to establish and investigate preclinical biomarkers in tissue samples. This position will report into the Executive Director of in vivo pharmacology. Key Responsibilities: Support the in vivo characterization of novel compounds by designing and conducting in life studies and performing molecular analysis with a combination of internal and outsourced resources. Work collaboratively across functions to support programs through preclinical proof of concept and candidate selection to advance the company pipeline. Use a high level of scientific judgment to adapt and/or create standard methods and techniques by applying breadth of knowledge and prior work experience. Develop and optimize preclinical biomarker assays to support discovery efforts and bridge into early development activities. Maintain excellent and timely recordkeeping while adhering to aggressive timelines Author study reports that may be used for regulatory filings and scientific manuscripts. Required Skills & Experience: Bachelor’s degree with 16+ years of experience, or Master’s degree with 10+ years of post-graduate experience, or Ph.D . with 6+ (industry experience is a plus). Degrees in Pharmacology, Neuroscience or relevant disciplines highly preferred. Experience with intrathecal and intracerebroventricular dosing in preclinical models Experience working in drug discovery with an emphasis on neurology indications, experience working with oligonucleotides is a plus. Designing and managing experiments at contract research organizations. Experience developing and optimizing assays in tissue matrix (i.e MSD, ELISA, qPCR), IHC skills a plus. Excellent verbal and written communication skills. Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects. Location(s): Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a lab-based position currently based in Bedford and will later be based in Waltham. Travel: This position will require approximately 5% travel. Compensation and Benefits: At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $154,000 - $179,000 **.** The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation. Our benefits package includes medical, dental and vision insurance; life, long and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP). Culture & Values: At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify. Stoke Therapeutics is a biotechnology company focused on enhancing protein output to treat severe diseases, particularly in the central nervous system and eye, using its TANGO platform. Biotechnology Research Research Services Professional Services Series B - RTW Investments, Apple Tree Partners $90M Oct 2018 Series A - Apple Tree Partners $40M Jan 2018 Footprint Where they work 45 Wiggins Ave, Bedford, Massachusetts 01730, US #J-18808-Ljbffr Stoke Therapeutics