Vice President, Strategic Purchasing & Purchasing

About Stoke: Stoke Therapeutics(Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered inBedford, Massachusetts. For more information, visit Position Purpose: We are seeking a Vice President, Strategic Sourcing and Procurement to serve as an enterprise leader responsible for designing, scaling, and overseeing Stoke’s strategic sourcing, procurement, and supplier governance capabilities as the company expands its operations, increases headcount and prepares for potential commercialization. Reporting to the Chief Financial Officer, this executive will build a high-impact function that enables disciplined spend management, enterprise risk mitigation, operational excellence, and strong partnerships across the entire company. The VP will act as a strategic advisor to senior leadership, establish procurement governance and decision‑making frameworks, lead complex supplier and contract negotiations, and ensure Stoke has the vendor infrastructure, controls, and commercial readiness required to support proper financial controls during rapid growth. Key Responsibilities: Establish and lead the enterprise strategic sourcing and procurement function, including the operating model, governance structure, policies, systems, controls, and performance expectations required to support a growing clinical‑stage and potentially commercial biotechnology company Serve as a strategic partner to the executive team and functional leaders, advising on sourcing strategy, supplier risk, contracting priorities, spend optimization, and vendor capabilities needed to advance corporate objectives Lead complex, high‑value RFPs/RFQs/RFIs and supplier selection processes in partnership with business stakeholders, legal, finance, quality, and compliance Oversee negotiation strategy for material agreements, ensuring favorable commercial terms, appropriate risk allocation, scalability, and alignment with business priorities Build and manage a strategic supplier relationship management program, including executive‑level vendor engagement, performance scorecards, issue escalation, corrective action planning, and lifecycle governance Lead enterprise spend visibility and analytics, identifying opportunities for cost avoidance, savings, process efficiency, consolidation, risk mitigation, and improved forecasting Partner with Finance and functional leaders to strengthen budget discipline, purchase‑to‑pay processes, contract lifecycle management, and alignment between sourcing decisions and financial planning Establish key procurement metrics and executive reporting to monitor performance, compliance, value creation, supplier concentration, risk, and continuous improvement opportunities Ensure procurement practices comply with applicable laws, regulations, company policies, quality expectations, and internal control requirements Build, mentor, and scale a high‑performing procurement team, fostering business partnership, accountability, continuous improvement, and a service‑oriented culture Partner with IT team to implement financial systems that enable better financial controls and spend management Maintain external awareness of market trends, supplier dynamics, technology innovation, and procurement best practices relevant to biotechnology, clinical development, and commercialization Required Skills & Experience: Minimum of 15 years of relevant strategic sourcing, procurement, vendor management, finance, or operations experience, including significant leadership experience in the pharmaceutical, biotechnology, or life sciences industry Demonstrated success building and scaling an enterprise procurement function in a high‑growth clinical development environment; commercialization readiness or commercial‑stage experience required Enabled companywide savings through outsourcing‑led initiatives over both short‑ and long‑term periods Bachelor’s degree required; advanced degree or relevant professional certification preferred Executive‑level understanding of drug development, clinical trials, CRO oversight, clinical supply chain, manufacturing, quality, regulatory expectations, and commercial readiness considerations Proven ability to influence senior leaders, lead cross‑functional decision‑making, and balance enterprise priorities across cost, quality, speed, risk, innovation, and compliance Extensive experience leading complex supplier negotiations and advising on material contract terms, business implications, risk allocation, service levels, performance obligations, and governance structures Strong financial and analytical acumen, including spend analysis, value creation, budgeting, forecasting, KPI development, and executive‑level reporting Experience selecting, implementing, or optimizing procurement processes, systems, contract lifecycle tools, purchase‑to‑pay workflows, and internal control frameworks Track record of building and leading high‑performing teams, developing talent, and creating scalable operating models in dynamic, fast‑paced environments Excellent executive communication skills, including the ability to distill complex issues, present recommendations, and drive alignment with senior management and cross‑functional stakeholders Location(s): Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a hybrid position, currently based in Bedford and will later be based in Waltham. Travel: This position will require approximately 10% travel. Compensation & Benefits: At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $227,000 - $345,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation. Our benefits package includes medical, dental and vision insurance; life, long‑ and short‑term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP). Culture & Values: At Stoke, we believe that innovation, the ability to successfully advance our ground‑breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee‑led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify. #J-18808-Ljbffr Stoke Therapeutics