Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Human Resources Director

Orchestra Life Sciences

The HR Director will build and lead the human resources function at Orchestra Life Sciences, establishing the people infrastructure, culture, and talent strategies that support the company's rapid growth across North America and Europe. Reporting directly to the CEO, this individual will manage the HR Manager and serve as both a strategic partner and a hands‑on practitioner, developing the HR capabilities Orchestra needs as it scales. This is a high-impact, foundational role for a seasoned HR professional who thrives in fast-moving, mission-driven environments. The ideal candidate combines deep expertise in talent acquisition, people operations, and organizational development with a genuine passion for life sciences and Orchestra's mission to accelerate novel treatments for cancer and rare disease. Candidates with a background in life sciences, biotech, pharmaceutical, professional services, or technical consulting are strongly preferred. Applicants from high-growth, project-based, or engineering-driven organizations will be considered but are not the primary target profile for this role. Key Responsibilities Build and lead Orchestra's HR function from the ground up, establishing scalable policies, programs, and systems spanning talent acquisition, onboarding, performance management, compensation, benefits, and compliance. Manage and develop the HR Manager, who reports directly to this role, provide direction, coaching, and support to build a high‑performing HR team. Partner with the CEO and senior leadership team to develop and execute people strategies aligned with Orchestra's growth objectives, values, and culture. Drive full-cycle talent acquisition across all functions — including technical, scientific, and consulting roles — ensuring a best‑in‑class candidate experience that reflects Orchestra's brand. Design and implement employee development, engagement, and retention programs that attract and retain top talent in the competitive life sciences market. Establish and maintain HR infrastructure including HRIS, employee handbooks, job architecture, compensation benchmarking, and benefits administration. Serve as a trusted advisor to managers and employees on HR policies, employee relations, performance management, and organizational matters. Ensure legal and regulatory compliance across all employment practices at the federal, state, and local level, including multi‑jurisdictional requirements across North America and Europe. Lead organizational design efforts in support of new service lines, practice areas, and geographic expansion including OLS Europe. Foster a culture of inclusion, collaboration, and excellence consistent with Orchestra's mission and values. Track, analyze, and report on HR metrics including organizational health, turnover, hiring velocity, and employee engagement to inform leadership decision‑making. Qualifications & Experience Bachelor's degree in Human Resources, Business Administration, Organizational Psychology, or a related field; SHRM‑SCP or SPHR certification preferred. 10+ years of progressive HR experience, with at least 3-5 years in a senior HR leadership role. Proven experience building or significantly scaling an HR function within a growth‑stage professional services, consulting, or life sciences organization. Deep knowledge of employment law, compensation strategy, benefits administration, and HR compliance across multiple jurisdictions. Demonstrated success with full‑cycle talent acquisition for technical, scientific, and consulting roles. Strong business acumen with the ability to align people strategies with organizational goals and operational realities. Excellent interpersonal and communication skills, with the ability to build trust and credibility at all levels of the organization. Experience implementing and managing HRIS platforms and HR technology stacks. Self‑starter mentality with the ability to work independently, manage multiple priorities, and deliver results in a dynamic, fast‑paced consulting environment. High degree of integrity, confidentiality, and professional discretion. Preferred Experience Experience supporting companies in the radiopharmaceutical, nuclear medicine, cell and gene therapy, or advanced biotech sectors. Familiarity with HR practices in professional services, engineering, or technical consulting firms. Experience managing multi‑jurisdictional HR compliance, including EU employment law in support of international operations. Track record of building employer brand and culture programs within a high growth organization. MBA or master's degree in Human Resources, Organizational Development, or a related field. Experience developing compensation frameworks and equity programs appropriate for a growth‑stage company. Why Join Orchestra Life Sciences Be part of a mission‑driven company accelerating novel treatments for cancer and rare disease. Join a rapidly growing consultancy with a global footprint and deep relationships across the advanced therapy ecosystem. Work alongside world‑class subject matter experts with over 100 years of combined industry experience. High visibility and direct impact — you will shape Orchestra's people strategy and culture at a pivotal moment of growth. Competitive compensation, benefits, and growth opportunities. #J-18808-Ljbffr

Vacancy posted 2 days ago
Similar jobs that could be interesting for youBased on the Human Resources Director in Saint Louis, MO vacancy
  • $140k - $160k

     ...Eurest Position Title: Human Resources Director Salary: $140000 - $160000 Other Forms of Compensation: 15% annual bonus potential As the leader in business and industry dining, Eurest is the company to join if you want a rewarding career packed with limitless... 
    Suggested
    Local area
    Flexible hours

    Compass Group, North America

    Saint Louis, MO
    1 day ago
  •  ...Human Resources Director Career Opportunity Valued and respected for your expertise in human resources and leadership abilities Are you searching for a career that's more than just a job, a calling that not only utilizes your professional skills but also connects you... 
    Suggested
    Full time
    Part time
    Work experience placement
    Home office
    Flexible hours

    Encompass Health Rehabilitation Hospital of Katy

    Saint Louis, MO
    10 days ago
  •  ...Overview Love animals and people? Apply to be our next Human Resources Director. The Humane Society of Missouri has a long history of helping animals find their forever homes. We are looking for a new HR Director who will serve the people who help our animals. Responsibilities... 
    Suggested
    Temporary work
    Flexible hours

    Humane Society of Missouri

    Saint Louis, MO
    3 days ago
  •  ...achieve better campaign results and transparency while improving advertising efficiencies to stimulate revenue growth The Director of Human Resources is the senior HR leader responsible for building and executing the people strategy at Drive Social Media. This role... 
    Suggested
    Work at office
    Local area
    Remote work
    Monday to Thursday
    Shift work

    Drive Social Media

    Saint Louis, MO
    4 days ago
  •  ...HR Director Sunset Hills Campus - St Louis, MO 63127 Job Description Summary: The Human Resource Director will facilitate daily HR functions like keeping track of employees' records and leading the interview process. Your role, also, involves performing tasks... 
    Suggested
    Work at office
    Local area
    Night shift
    Afternoon shift

    Faith Church

    Saint Louis, MO
    5 days ago
  •  ...Director Of Human Resources The Director of Human Resources serves as a role model, creating positive relationships with staff in an environment of mutual respect and trust. The Director is a strong advocate for employees, cultivates and enhances an atmosphere of continuous... 
    Monday to Friday

    CareSTL Health

    Saint Louis, MO
    5 days ago
  • $80k

     ...Director of Human Resources Saint Louis County Office - St Louis, MO 63119; Administrative MO - Saint Louis, MO 63303 Description Are you a self-motivated, detail-driven HR leader who thrives in a fast-paced, mission-focused environment? Assistance Home Care is... 
    Weekly pay
    Work at office

    Assistance Home Care

    Saint Louis, MO
    2 days ago
  •  ...reduce administrative burdens, improve outcomes, and support long-term success. We are seeking an experienced and dynamic Director of Human Resources to serve as a strategic partner to our leadership team and facilities across the organization. This is an exciting... 
    Local area

    Reliant Care Management Company

    Saint Louis, MO
    3 days ago
  • $110k - $140k

     ...recruiting as a strategic capability. Reporting to the Talent Director, and working in close partnership with the Recruiting Partner...  ...professional development. Partner with the Investing team, Human Resources leaders, and external talent partners to support talent diligence... 
    Temporary work
    Live out
    Work at office
    Home office
    Flexible hours
    Shift work
    2 days per week
    1 day per week

    Granite Partners

    Saint Louis, MO
    2 days ago
  •  ...Job Description Summary Under the direction of the Director of Human Resources, the Human Resources Manager works with all human resources staff to carry out the daily activities of the Human Resources department, including recruitment, benefits and compensation, employee... 
    Temporary work
    Local area

    Sonesta Hotels International Corporation

    Saint Louis, MO
    3 days ago
  • $60k

     ...Charities of the Archdiocese of St. Louis is seeking a skilled Human Resources Manager to provide hands‑on HR support across several social...  ...lifecycle, and escalates non‑routine issues to the Senior Director and Director of Human Resources. This role works across the St... 
    Work at office
    Local area

    Archdiocese of St Louis

    Saint Louis, MO
    4 days ago
  •  ...designed to support your personal and family well-being. Mayo Clinic Programs: Access exclusive programs from the Mayo Clinic, including resources for workouts, lifestyle, mental health, and diet to promote a balanced and healthy lifestyle. These additional benefits are... 

    Reliant Care Management, LLC

    Saint Louis, MO
    1 day ago
  •  ...with a portfolio of powerful, globally recognized brands as a Human Resource Manager ! The Human Resources Manager will serve as a...  ...Primary Duties & Responsibilities Change Management. Work with the Director of HR and leadership to evaluate the level of change and transformation... 
    Work experience placement
    Work at office
    Remote work
    Monday to Friday

    Spectrum Brands

    Saint Louis, MO
    4 days ago
  • PI AgSciences ( is part of PI Industries and a technology leader in agricultural biologicals and crop protection products. PI AgSciences is seeking a dynamic and results-driven HR Manager to help create and sustain a collaborative, innovative, and high-performance culture...

    PI Industries

    Saint Louis, MO
    4 days ago
  •  ...Travel: Approximately 25% (Locally within MO) The Opportunity We are seeking an experienced Human Resources Manager to support a multi-site distribution operation throughout the St. Louis market. This is a highly visible HR leadership role partnering directly with operations... 
    Work at office
    Local area

    Co-nexus

    Saint Louis, MO
    5 days ago
  •  ...Overview Imo's Holdings is seeking an experienced Human Resources Manager to lead and support all aspects of Human Resources for our manufacturing and distribution operations in St.Louis. This is an excellent opportunity for a hands‑on HR professional who enjoys balancing... 
    Hourly pay
    Local area
    Relocation package

    Imo's Foods Inc.

    Saint Louis, MO
    4 days ago
  • $103.65k

     ...The City of Clayton is now accepting applications for the position of Human Resources Manager . The Human Resources Manager is responsible for managing all aspects of the City's human resources functions. This includes recruitment, employee relations, benefits administration... 
    Full time
    Part time
    Seasonal work
    Immediate start
    Flexible hours

    City of Clayton

    Saint Louis, MO
    2 days ago
  • $152k - $228k

     ...Position Summary The Associate Director, Oracle HCM Recruiting serves as the strategic, functional, and delivery leader for Grant Thornton...  ...optimization and continuous improvement. Team Leadership & Resource Management Lead, coach and develop HRIS Recruiting resources (Associates... 
    Full time
    Internship
    Seasonal work
    Local area

    Grant Thornton

    Saint Louis, MO
    2 days ago
  •  ...producers in Accounting & Finance, Legal, Information Technology, Sales & Marketing, Engineering/Manufacturing/Supply Chain, and Human Resources. Requirements: 1-5 years or more of sales, telesales, business development, consulting or recruiting experience preferred We... 
    Work at office

    Lucas Group

    Saint Louis, MO
    5 days ago
  •  ...committed to investing in our people and providing the training and resources they need to learn, grow, and advance. Are you Built for the...  ...opportunities Philanthropy opportunities Position Overview The Human Resources Business Partner assists the Human Resources... 
    For subcontractor
    Work at office

    Alberici

    Saint Louis, MO
    2 days ago
  •  ...of St. Louis, the State of Missouri, and the Women’s Business Enterprise National Council. MAJOR GOALS AND RESPONSIBILITIES The Human Resources Business Partner (HRBP) serves as a trusted advisor to employees and managers by supporting the full spectrum of HR functions.... 
    Full time
    Summer work
    Summer internship
    Work at office
    Local area

    Tarlton

    Saint Louis, MO
    2 days ago
  • $75k - $85k

     ...qualified individuals with disabilities, upon request. Seniority level Mid-Senior level Employment type Full-time Job function Human Resources Referrals increase your chances of interviewing at Addison Group by 2x Benefits Medical insurance Vision insurance 401(k) #J-18... 
    Full time
    Local area

    Addison Group

    Saint Louis, MO
    2 days ago
  •  ...Job Description Job Description Payroll & HR Director Company: Luxor Healthcare Luxor Healthcare is looking for an experienced Payroll & HR Director to join our fast-paced and supportive administrative team. With several Skilled Nursing Facilities across... 

    Luxor Healthcare

    Saint Louis, MO
    27 days ago
  •  ...Job Description Job Title: Human Resource Business Partner Location: Saint Louis, Missouri Department: SS People & Culture Employment Type: Full Time Job Summary Join our dynamic and collaborative team as a Human Resource Business Partner, where you will play a key role... 
    Full time
    Work at office
    Local area

    Dormont Manufacturing Company

    Saint Louis, MO
    4 days ago
  •  ...(EAP) offering mental health, financial, and personal support resources. ~ Incentive Program Eligibility for performance-based incentive...  ...Required Qualifications ~ Bachelor's degree in finance, human resources, business administration, or related field- 8+ years... 

    MLC

    Saint Louis, MO
    3 days ago
  • TalentCompass is seeking a Senior HR Generalist to partner with leaders across the organization, guiding talent development, workforce planning, and employee relations. The role emphasizes data-informed people solutions to drive a high-performing culture. You will coach...

    TalentCompass

    Saint Louis, MO
    12 hours ago
  • Responsibilities Kforce's client located in the Saint Louis, MO area is seeking an experienced Senior Benefits Manager professional to lead the strategy, administration, and continuous improvement of employee benefit programs. In this role you will need to have large firm...
    Hourly pay
    Contract work

    Kforce

    Saint Louis, MO
    3 days ago
  •  ...St. Louis-based provider of Cyber Security, Managed Services, and Information Technology solutions.   The Office Manager / Human Resources Manager at Forward Slash Technology is responsible for overseeing daily office operations of currently 20-30 employees and managing... 
    Full time
    Work at office
    Local area

    Forward Slash Technology

    Saint Louis, MO
    1 day ago
  •  ...as appropriate. Key Requirements and Technology Experience: Must have skills: Employee relationships, Onboarding, HR Partner, Human Resources. 5 years of experience in employee relations and labor relations. Bachelor's Degree. Bachelor's Degree in an HR discipline. Extensive... 
    Contract work
    Local area
    Immediate start

    Brightlitalent

    Saint Louis, MO
    1 day ago
  •  ...supporting the accurate processing and recording of U.S. and Canadian payrolls while assisting with benefits administration and general human resources activities. This role works closely with internal stakeholders and external vendors to ensure compliance, data accuracy, and a... 
    Full time
    Local area

    Confidential

    Saint Louis, MO
    4 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Human Resources Director. Be the first to apply!