Senior Scientist, Cell Therapy Islet

What you’ll do: Execute routine 2D and 3D PSC expansion, passaging, and directed SC-islet differentiation Design optimization experiments to achieve a scalable, robust 3D SC-islet differentiation process compliant with manufacturing standards Optimize differentiation protocol for highly pure on-target populations Operate closed systems (tube welder, sealer, single-use assemblies) Set up and run controlled bioreactors; manage automation and process control (DO, pH, perfusion, agitation) Collaborate and communicate experimental findings Maintain strong scientific documentation; contribute to SOP development Ensure lab safety and biosafety compliance Contribute to team execution and feedback; support multidisciplinary collaboration while meeting deadlines What we’re looking for: PhD in stem cell biology or biochemical/biomedical engineering (or related) with 3–5 years of direct cell therapy industry experience Strong experience operating suspension culture bioreactors Bioreactor control software/process development tools and/or DOE-based optimization (preferred) Experience operating closed cell culture systems Flow cytometry and immunofluorescent staining experience Proficiency with flow cytometry/imaging software (e.g., FACSDiva, FlowJo, ImageJ, Halo) What will separate you from the crowd: Directed stem cell differentiation toward pancreatic islet lineage Ability to optimize differentiation yield and reproducibility across platforms Interest in GMP transition, automation, and continuous process improvement Experience with large bioreactors (15L+) Cross-functional collaboration experience advancing cell therapies to the clinic Base pay range: $160,000–$190,000/year (varies by factors such as location, knowledge, skills, and experience) #J-18808-Ljbffr Scorpion Therapeutics