Senior National Account Director - Commercial Payers

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit Follow Mineralys on LinkedIn, Twitter and Bluesky” Mineralys is a fully remote company. The Senior National Account Director– Commercial Payers will report to the SVP, Market Access and play a critical leadership role in shaping and executing our U.S. market access strategy with national and large regional commercial payers in preparation for our first cardiovascular product launch. This is a high-impact, field-based position responsible for building relationships with key payer stakeholders, communicating product value, and securing favorable coverage and reimbursement pathways. This is a highly strategic, hands-on role that is ideal for an experienced national account professional who thrives in fast-paced, build-from-scratch environments and understands the complexity of securing access for innovative, high-value therapies. Responsibilities Lead strategic engagement with national and large regional commercial PBMs and payers (e.g., UnitedHealthcare, ESI, Aetna, Anthem, Cigna, CVS/Aetna, Elevance, etc.). Build and manage relationships with key decision-makers across payer organizations. Analyze the competitive landscape and coverage policies to anticipate payer needs and barriers. Profile key payer accounts and execute account engagement plans to educate payer stakeholders on unmet need, science, disease burden, and anticipated value proposition. Identify and address potential barriers to access proactively to ensure product is well positioned for formulary and P&T reviews Identify competitive threats and develop strategies to ensure optimal coverage for lorundrostat. Lead pull-though initiatives that capitalize on formulary wins and lead push-though efforts in areas with access challenges Partner with internal teams (Market Access Strategy, Contracts and Pricing, HEOR, Medical Affairs, Clinical, Regulatory) to develop and tailor payer-facing materials, including early scientific exchange, evidence dossiers, PIE presentations, and budget impact models. If required, identify, shape, and lead negotiation of innovative contracting opportunities aligned with Mineralys Therapeutics, product profile, and payer priorities. Serve as the internal voice of the payer and provide strategic guidance to senior leadership on coverage risks, opportunities, and commercial landscape dynamics. Ensure all engagements and materials are fully compliant with legal, regulatory, and corporate standards. Cross-Functional Integration & Collaboration Serve as a key commercial liaison across internal stakeholders, including Market Access Leadership, Medical Affairs, Marketing, Patient Services, Finance, and Regulatory, to ensure alignment on strategic initiatives and execution plans that support national account objectives. Collaborate with the Medical Value & Outcomes MSLs to support the communication and translation of complex scientific and economic value propositions into compelling narratives for diverse payer stakeholders. Collaborate with the Patient Support Services team to support the patient journey and resolve coverage issues. Assist Regional Sales teams with pull- or sell-through strategies based on payer coverage. Represent Mineralys at industry events, including Asembia, AMCP, and other relevant conferences. Lead cross-functional account planning sessions to synthesize market insights, anticipate customer needs, and develop tailored engagement models that drive optimal therapeutic adoption and long-term value creation. Facilitate seamless internal coordination and communication to ensure the delivery of compliant, consistent messaging and solutions that reflect both the scientific innovation and commercial strategy of the organization. Drive organizational readiness and pull-through efforts across functional teams pre- and post-launch to ensure market access success in a highly regulated and evolving policy landscape. Success Metrics Achievement of targeted payer coverage milestones and KPIs Breadth and depth of payer access across account(s) Execution of innovative contracting, if required Internal alignment and readiness to support access and alignment efforts About You Proven track record of managing national commercial payer accounts and contract negotiations, including pre-launch and launch readiness. Established relationships with key PBM, GPO, and payer decision-makers. ( FYI I want someone who already has relationships, ideally at Optum and United) Strong grasp of payer decision-making processes, formulary management, medical policy development, and specialty pharmacy dynamics. Demonstrated ability to thrive in early-stage or launch environments, operating with agility and strategic foresight. Excellent communicator who can convey complex scientific and economic data to non-scientific audiences. Strong project management and cross-functional leadership skills. Excellent negotiation skills and analytical capabilities. Comfortable operating in ambiguity with a strong bias for action and accountability. Bachelor's degree required; MBA or other graduate degree preferred. 8+ years of pharmaceutical or biotech market access experience, field-based payer account management, or managed markets strategy. Travel Up to 50%, including partner meetings, conferences, and internal cross-functional workshops. These positions are eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level. US Salary Range: $240,000 - $265,000

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