Oligo Chemistry and Biochemistry Co-op (Spring 2027)

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.Scope: Wave Life Sciences USA seeks highly motivated co-op students to join its team of scientists in Cambridge, Massachusetts. The co-op student will gain exposure to areas of oligonucleotide chemistry, and biochemistry/bioanalytical chemistry. Co-ops will be trained in a variety of laboratory techniques and instrumentation, making this an excellent learning opportunity. This is an ideal position for any student, including those looking for their first co-op, with strong organizational skills and attention to detail who thrives in a team-oriented, fast-paced and cross-disciplinary biotech environment. Organic chemistry or biochemistry laboratory experience is preferred. ResponsibilitiesAssist in the upstream and downstream biochemical/bioanalytical and biological analysis of oligonucleotidesPreparation of reagents and buffers for biochemical/bioanalytical and biological experiments by measuring the weight of organic compounds and the volume of solutionsPreparation of buffer solutions of specified molarity for Liquid Chromatography (LC) analysis of oligonucleotidesAssist in the operation of Liquid Chromatography Mass Spectrometry (LCMS) system and be able to learn and work on the systemAssist in the physicochemical experiments (thermal denaturing experiment etc.) of oligonucleotidesMaintain a detailed report of experimental procedures and findings in electronic lab notebooksUse of pH meter, Nanodrop to record dataUse of MS Excel is preferredSkills and CompetenciesPresent experimental data in team meetingsEager to learn about instrumentation and work with new technologyFollowing the lab safety protocols including use of PPEsPay Range Disclosure Statement$24—$30 USDThe range provided is based on what we believe is a reasonable estimate for the annual base salary pay range for this position at the time of posting. Actual annual base salary will vary based on several factors including, but not limited to, relevant skills, experience, qualifications, position criticality, and internal equity. This position is eligible for a discretionary annual bonus and discretionary stock-based long-term incentives. In addition to compensation, Wave offers a comprehensive and competitive range of benefits designed to support our employees’ and their families physical and financial health and overall well-being. These include, but are not limited to, company-sponsored medical, dental, vision, life, long and short-term disability insurances, generous paid time off (including a week-long company shutdown in the Summer and the Winter), 401K participation with matching contributions, and Employee Stock Purchase Program. Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. 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