Senior Program Manager, Direct-to-Patient

Role Description

Join Amgen’s Mission of Serving Patients. This role will support the U.S. launch of MariTide, Amgen is building a Direct-to-Patient (DTP) channel that operates alongside traditional access pathways. The model combines digital intake, telehealth-enabled care, and end-to-end fulfillment into a single, integrated experience that routes patients across cash-pay and reimbursed options based on their needs and coverage.

Reporting to the Executive Director, US Direct-to-Patient Lead, the Senior Program Manager drives the execution and launch readiness of this model. This is a high-visibility role at the center of a fast-moving, highly regulated program where execution directly affects patient conversion, adherence, and long-term franchise growth.

Key Activities and Accountabilities

• Program Management & Launch Readiness
  • Build and own the integrated DTP launch plan and roadmap spanning intake, telehealth, prescribing, fulfillment, billing, and patient support, with clear milestones, owners, and critical path.
  • Manage cross-workstream dependencies, timelines, and resourcing; surface trade-offs early and keep the program tracking to committed launch dates.
  • Run launch-readiness and Go/No-Go processes, including readiness criteria, checklists, and end-to-end dry runs.
  • Lead risk, issue, and action management (RAID), driving timely escalation and resolution.
• Cross-Functional Orchestration
  • Coordinate execution across Marketing, Value & Access, Medical, Regulatory, Legal, Tax, Operations, and Commercial Data & Analytics (CD&A).
  • Drive decisions through established governance forums; capture and track decisions, actions, and follow-through to closure.
  • Produce clear status reporting and executive updates that give leadership a reliable view of progress, risk, and readiness.
• Partner & Vendor Program Management
  • Coordinate onboarding, integration, and testing of telehealth, fulfillment, pharmacy, and platform partners in support of the partner strategy set by the Executive Director.
  • Plan and manage UAT and end-to-end testing across the patient journey; track defects to closure.
  • Monitor partner readiness and SLA commitments ahead of launch and flag gaps with enough runway to act.
• Operating Cadence & Governance
  • Establish and run the program operating rhythm, including steering committees, workstream syncs, and reporting cadence.
  • Maintain the single source of truth for plan, status, decisions, and risks.
  • Develop pre-reads and materials that drive efficient, decision-oriented meetings.
• Performance Tracking & Continuous Improvement
  • Partner with CD&A to stand up dashboards and KPIs for conversion, adherence, SLA performance, and channel effectiveness.
  • Track performance against plan and support structured testing and optimization.
  • Lead retrospectives and capture lessons learned to strengthen readiness for future indications and launch waves.

Qualifications

• Doctorate degree and 2 years of program/project management, commercial, digital health, or operations experience OR
• Master's degree and 4 years of program/project management, commercial, digital health, or operations experience OR
• Bachelor’s degree and 6 years of program/project management, commercial, digital health, or operations experience OR
• Associate’s degree and 10 years of program/project management, commercial, digital health, or operations experience OR
• High school diploma / GED and 12 years of program/project management, commercial, digital health, or operations experience

Requirements

• Program or project management experience in digital health, pharma/biotech commercialization, telehealth, or consumer health.
• Proven skill navigating matrixed organizational structures, moving with speed and accountability without burning bridges or circumventing necessary steps.
• Track record managing complex, multi-stakeholder launches under compressed timelines, including Go/No-Go decision frameworks.
• Experience coordinating internal and external partners and vendors (IT, marketing, fulfillment, telehealth, pharmacy, platform, and others), including integration testing, UAT, and SLA tracking.
• Comfort operating in highly regulated environments, partnering closely with Legal, Regulatory, Compliance, and Government Pricing.
• Technical fluency to partner with product and engineering on system integration, API integrations, data flows, and performance dashboards.
• Proficiency with program/project management tools and methods (e.g., Smartsheet, Jira, MS Project; Agile and waterfall); CSM, PMP, or equivalent certification a plus.
• Strong communication, stakeholder management, and executive reporting skills.
• Data-driven mindset with comfort navigating ambiguity and competing priorities in a high-visibility launch environment.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models where possible.

Company Description

Amgen is an organization dedicated to improving the quality of life for people around the world, fostering an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.