Postdoctoral Fellow - The Wang Laboratory

Overview The Wang Laboratory at MD Anderson Cancer Center is a computational biology research lab. We apply innovative bioinformatics approaches to dissect the tumor ecosystem, deeply profile tumor cells and cells of the tumor microenvironment as well as tumor-immune-stroma crosstalk at single-cell resolution and in the spatial context. The lab's key focus areas include: 1) transition from premalignant lesions to invasive cancer; 2) evolution of metastasis from a localized tumor; 3) dynamic response to anti-cancer therapies and the development of therapeutic resistance. Leveraging cutting-edge single-cell and spatial multi-omics technologies, cellular imaging, and innovative bioinformatics tools and computational frameworks, we aim to harness the potential of big data to fight cancer. Our overarching goal is to advance understanding of the cellular and molecular cues underlying early tumorigenesis, disease progression, and therapy resistance and translate our discoveries into improved patient care. We are seeking multiple talented and highly motivated Postdoctoral Fellows with a strong background in bioinformatics and a passion for exploring the heterogeneity and evolution of tumor cells and tumor microenvironment using state-of-the-art single cell and spatial multi-omics approaches. Learning objectives Gain skills in single cell, spatial omics, and imaging data analysis, immunogenomics, immune-informatics, and cancer-specific bioinformatics. Develop expertise in study design, data analysis, data interpretation, presentation, manuscript and grant writing. All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations. Eligibility Requirements Individuals with a PhD degree in computational biology, bioinformatics, data science or a related field are encouraged to apply. A strong computational background, proficiency in R and at least one additional scripting language (e.g., Python) and knowledge in biostatistics are required. Experience working with single cell and spatial omics data analysis and high-performance computing environment (Unix/Linux) is highly preferred. A good understanding of cancer biology, immunology, cell biology, and molecular biology is also preferred. Proven track record of publications, excellent spoken and written communication skills are required. Additional Application Information Interested applicants should send a Cover Letter specifying past research experience/skills/accomplishments, a Curriculum Vitae and the contact information of three referees to Dr. Linghua Wang at View email address on click.appcast.io with the subject line entitled "Postdoctoral Fellow - Application - Applicant's Name". Position Information MD Anderson offers full-time postdoc positions with a salary ranging from $64,000 to $76,000, depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent benefits, including medical, dental, paid time off, retirement, tuition benefits, educational opportunities, and individual and team recognition. Offsite work arrangements are subject to approval and may be modified or revoked at any time based on business needs, performance considerations, or regulatory requirements. This position may be responsible for maintaining the security and integrity of critical infrastructure, and may require routine reviews and screening. The ability to satisfy and maintain all requirements necessary to ensure the continued security and integrity of such infrastructure is a condition of hire and continued employment. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. Faculty Mentor Dr. Linghua Wang #J-18808-Ljbffr MD Anderson Cancer Center