Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Principal Scientist

$143.2k - $265.9k

Genentech

The Position THE OPPORTUNITY The Department of Immunology Discovery at Genentech is excited to announce an opportunity for a Principal Scientist, Lab Head, to lead a research group focused on designing next-generation cell therapies to treat autoimmune diseases. The successful candidate will lead a highly productive research team, integrating efforts across cross-functional teams to identify new targets and therapeutic hypotheses, and to advance transformative therapeutics from preclinical studies into early clinical development. The ideal candidate will have a deep understanding of cellular immunology principles and pathways relevant to the biology of autoimmune disease, including but not limited to inflammatory bowel disease, multiple sclerosis, lupus and chronic obstructive pulmonary disease. Excellent communication skills are essential to facilitate fruitful collaborations with colleagues across a diverse array of departments, including computational biology, proteomics and tissue genomics, drug development, early clinical development, and translational medicine. Key responsibilities include leading and managing a highly-productive research team, generating high-quality, original research that advances our understanding of autoimmune disease and contributing directly to the initiation and advancement of novel pipeline projects. The successful candidate may also play a critical role within cross-functional teams evaluating external business development opportunities to accelerate our cell therapy pipeline.

WHO YOU ARE

The ideal candidate will have: PhD and postdoctoral training in Immunology, Cell Biology or related field A minimum of 5 years post-PhD experience with a record of high-impact publications (preprints considered), patents, and/or a proven track record advancing therapeutic candidates from pipeline entry to early clinical development Demonstrated expertise in cellular immunology and a deep understanding of pathways and immune cell types that contribute to autoimmune disease Outstanding leadership and a collaborative spirit, with a proven track record of working with multidisciplinary teams Excellent written and verbal communication skills, with the ability to communicate complex scientific concepts to multidisciplinary audiences Exceptional critical thinking skills, a commitment to rigorous experimental design and creative problem-solving, and a demonstrated ability to use data-driven insights to guide scientific decisions Preferred qualifications: Expertise in both B cell and T cell biology Experience engineering, modifying, and functionally evaluating human immune cells Experience working with mouse models, including humanized models Relocation benefits are available for this job posting. The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. #J-18808-Ljbffr Genentech

Vacancy posted 2 days ago
Similar jobs that could be interesting for youBased on the Principal Scientist in South San Francisco, CA vacancy
  • Denali Therapeutics Inc in South San Francisco, CA, seeks a Principal Scientist to lead formulation and drug product development for a growing portfolio of protein biologics. You will design studies, establish shelf life, and support comparability across development stages... 
    Principal

    Denali Therapeutics Inc

    South San Francisco, CA
    3 days ago
  • Amgen seeks a highly skilled Principal Scientist to lead GEM molecular characterization and validation. You will advance CRISPR‑based model generation, orthogonal QC, and sequencing workflows, enabling scalable, AI‑driven analysis. The role requires deep experience with... 
    Principal

    Amgen SA

    South San Francisco, CA
    1 day ago
  • IDEAYA Biosciences in South San Francisco is seeking a talented discovery medicinal chemist to lead projects and propose novel molecules that advance oncology programs. You will work in a cross-functional team, design and synthesize drug-like candidates, and push compounds...
    Principal

    BioSpace

    South San Francisco, CA
    3 days ago
  • $168.6k - $313k

     ...s what makes us Genentech. The Opportunity We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics... 
    Principal
    Local area
    Relocation package

    Genentech

    South San Francisco, CA
    14 hours ago
  • Genentech, a Roche unit in South San Francisco, seeks a Senior/Principal Scientist to lead computational neuroscience initiatives within the CS-CoE. Develop data-driven strategies, mine large omics datasets, and identify biomarkers for neurodegenerative and neuroinflammatory... 
    Principal
    Relocation package

    F. Hoffmann-La Roche AG

    South San Francisco, CA
    2 days ago
  • $155k - $200k

     ...biology of epigenetic aging and disease using experiments of unprecedented scale. This Position NewLimit is seeking a Senior/Principal Scientist with deep expertise in molecular biology and translational biomarker assay development. In this role, you will lead the discovery... 
    Principal

    Quiet Capital

    South San Francisco, CA
    5 days ago
  •  ...-based medicines to transform the treatment of genetic heart disease. We are seeking a highly skilled and hands-on Senior to Principal Scientist to join our Protein Science team. This role will focus on developing and executing antibody-oligonucleotide conjugate (AOC) production... 
    Principal

    Myoventive, Inc.

    South San Francisco, CA
    2 days ago
  • $143.2k - $265.9k

     ...The Position The Opportunity We are seeking a creative and highly motivated Principal Scientist, Medicinal Chemist to join our R&D team. This is a primarily lab-based, technical leadership position within the Peptide Therapeutics department. In this lab-based leadership... 
    Principal
    Local area
    Relocation package

    Genentech

    South San Francisco, CA
    2 days ago
  • $173.1k - $321.5k

    The Position We advance science so that we all have more time with the people we love. The Senior Principal Scientist serves as the scientific leader for Bioanalytical Strategy in support of our Cell Therapy portfolio. In this role, the individual will define and drive... 
    Principal
    Local area
    Relocation package

    Genentech

    South San Francisco, CA
    2 days ago
  • $168.6k - $313k

    The Opportunity We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to lead and mentor a multidisciplinary team in our Peptide Therapeutics department. The role will focus on advancing peptide therapeutics from discovery through... 
    Principal
    Local area
    Relocation package

    F. Hoffmann-La Roche AG

    South San Francisco, CA
    2 days ago
  • About the Role Onsite (South San Francisco, CA). Principal Scientist, Potency; reports to Sr. Director, Head of Molecular and Potency Method Development. Responsibilities Develop and qualify pivotal stage potency, immunoassay, and other cell-based methods to support characterization... 
    Principal
    Work at office

    Scorpion Therapeutics

    South San Francisco, CA
    4 days ago
  • $143.29k - $266.11k

    This role is a vital part of our Cell Therapy Process Development team within Pharma Technical Cell and Gene Therapy Development (PTCC), which is committed to advancing next-generation cell therapies through innovative metabolomics research and media optimization. As a ...
    Principal
    Local area
    Relocation package

    F. Hoffmann-La Roche AG

    South San Francisco, CA
    5 days ago
  • $150k - $180k

    We are seeking a Senior/Principal Scientist to lead the bioanalytical/analytical characterization of our oligonucleotide therapeutics. The role blends strong mass spectrometry capability with a broader bioanalytical and pharmacokinetic remit: you will develop and apply... 
    Principal
    Full time

    Switch Therapeutics

    South San Francisco, CA
    5 days ago
  • $159k - $207k

     ...consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.We are seeking a Principal Scientist to join our Formulation & Drug Product Development team to serve as a formulation and drug product process development lead... 
    Principal
    Contract work
    Local area

    Denali-Therapeutics

    South San Francisco, CA
    3 days ago
  • $159k - $207k

    ## Principal Scientist, Commercial & Late-Stage Cell Culture Process DevelopmentApplylocations: South San Franciscotime type: Full timeposted on: Posted 2 Days Agojob requisition id: R-1619Neurodegenerative diseases are one of the largest medical challenges of our time.... 
    Principal
    Work experience placement
    Local area

    Denali Therapeutics

    South San Francisco, CA
    4 days ago
  • $194.1k - $305.6k

     ...Job Description The South San Francisco DMPK organization is seeking an accomplished and highly collaborative Senior Principal Scientist to provide scientific leadership across drug conjugate discovery and development programs, support strategic portfolio decisions,... 
    Principal
    Full time
    Contract work
    For contractors
    Local area
    Relocation
    Visa sponsorship
    Flexible hours
    Shift work

    Merck & Co.

    South San Francisco, CA
    28 days ago
  • $143.2k - $265.9k

    The Opportunity SE7 As a Principal Scientist in Small Molecule Biomarkers (Metabolomics & Lipidomics) within our Drug Metabolism and Pharmacokinetics (DMPK) team, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research... 
    Principal
    Local area
    Relocation package

    F. Hoffmann-La Roche AG

    South San Francisco, CA
    2 days ago
  •  ...them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Scientist - GEM Molecular Validation & Technologies What you will do Let’s do this. Let’s change the world. We are seeking an experienced... 
    Principal
    Flexible hours

    Amgen SA

    South San Francisco, CA
    1 day ago
  • $180k - $215k

     ...opportunity to change the cell therapy landscape. Overview Nkarta is seeking a highly motivated, collaborative, detail-oriented Principal Scientist to join our Translational Medicine team. This is a high-impact, hands-on leadership role for a senior bioinformatics... 
    Principal
    Full time
    Work at office
    Flexible hours
    Shift work

    Nkarta, Inc.

    South San Francisco, CA
    more than 2 months ago
  • $159.6k - $251.2k

     ...Job Description Job description: We are seeking a highly motivated Associate Principal Scientist to join a bicoastal Discovery Oncology, Reverse Translation Team in South San Francisco. This role is an exciting opportunity to contribute to reverse translation efforts... 
    Principal
    Full time
    For contractors
    Local area
    Relocation
    Visa sponsorship
    Flexible hours
    Shift work

    Merck & Co.

    South San Francisco, CA
    20 days ago
  • $142.4k - $224.1k

     ...concept and into late-stage development, supporting worldwide marketing applications and lifecycle management. The Early Clinical Scientist (ECS) provides operational and scientific leadership, along with therapeutic expertise, for the design, planning, and execution of... 
    Principal
    Full time
    For contractors
    Local area
    Worldwide
    Relocation
    Visa sponsorship
    Flexible hours
    Shift work

    Merck & Co.

    South San Francisco, CA
    23 days ago
  • $167k - $206k

     ...demonstrating a calm and positive attitude and a superior work ethic. Ability to supervise and mentor junior level associates and/or scientists, including direct reports or supporting team members. Employee Expectations All employees are expected to act with integrity and... 
    Principal
    Contract work
    Temporary work
    Work at office
    Local area
    Work from home
    Shift work
    1 day per week

    IDEAYA

    South San Francisco, CA
    2 days ago
  • $177k - $218k

     ...employees and 90 % company paid for dependents), 401k, ESPP, and wellness programs. The expected salary range for the role of Principal Research Scientist, Medicinal Chemistry is $177,000 - $218,000. The final salary offered to a successful candidate will depend on several... 
    Principal
    Temporary work
    Work at office
    Local area
    Work from home
    1 day per week

    IDEAYA Biosciences, Inc.

    South San Francisco, CA
    4 days ago
  • $175k - $200k

     ...autoimmune disease. Based in South San Francisco, California, our scientists are pioneering innovative technology to advance the next...  ...Summary We are seeking a highly motivated and experienced Principal Scientist / Associate Director to join our Translational Biology... 
    Principal

    Dualitas Therapeutics

    South San Francisco, CA
    12 days ago
  • Genentech in South San Francisco seeks a Principal Scientist (Group Leader) to drive oligonucleotide modalities across drug-discovery programs. You will design, synthesize, purify, and characterize ASOs/siRNAs, mentor scientists, and partner with biology teams to enable... 
    Principal

    Genentech

    San Francisco, CA
    2 days ago
  • $278.53k - $345.04k

     ...Communicate with the industry and communities where applicable and be ambassador for Roblox. You have: You have 7+ (for principal) or 4+ (for senior) years of experience designing and building scalable machine learning solutions. Experienced with transformer... 
    Principal
    Full time
    Work experience placement
    H1b
    Work at office
    Local area
    Visa sponsorship
    Monday to Friday

    Roblox

    San Mateo, CA
    2 days ago
  • $195.67k - $253.22k

     ...confronting the largest public health challenges of our day and improving the lives of patients for generations to come. As a Principal Scientist, Analytical Operations at Gilead you will act as the Quality Control (QC) Lead and will be responsible for the strategic... 
    Principal
    Contract work
    For contractors
    Local area

    Gilead Sciences

    Foster, CA
    1 day ago
  • $177k - $235k

     ...inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description:We are seeking an innovative Principal Scientist to bridge the gap between traditional antibody discovery and cutting-edge computational design. In this role, you will serve... 
    Principal

    Calico Life Sciences

    South San Francisco, CA
    14 hours ago
  • $202.8k - $376.6k

     ...power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative...  ...about advancing the frontier of AI for biology.As a Senior Principal Scientist, you will lead a team developing AI models that... 
    Principal
    Full time
    Local area
    Worldwide
    Relocation package

    Genentech

    South San Francisco, CA
    4 days ago
  • $144.9k - $269.1k

     ...power of data and Artificial Intelligence (AI) to assist our scientists in delivering more innovative and transformative medicines for...  ...postdoctoral research or 3 years equivalent experience after PhD (Principal Scientist). The ideal candidate will have deep experience in... 
    Principal
    Full time
    Local area
    Worldwide
    Relocation package
    3 days per week

    Genentech

    South San Francisco, CA
    1 day ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Principal Scientist. Be the first to apply!