Senior Research Associate, in vivo Pharmacology

Stoke Therapeutics seeks a Senior Research Associate to execute in vivo pharmacology studies using rodent models in support of antisense oligonucleotide development. The role involves hands-on study design, animal procedures, behavioral assessments, and data analysis within a preclinical research team.

Responsibilities

• Design and execute complex in vivo rodent studies across CNS and other therapeutic programs in collaboration with cross-functional scientists
• Perform surgical procedures and multiple routes of drug administration with anesthesia monitoring and tissue sampling
• Conduct dose-response, pharmacokinetic/pharmacodynamic, tolerability and efficacy studies in mice and rats
• Assess animal phenotypes using behavioral assays and analyze experimental data using appropriate statistical methods
• Maintain breeding colonies, perform genotyping, prepare samples for molecular assays, and document records and protocols

Requirements

• Bachelor's degree with 4+ years experience or Master's degree with 2+ years experience in pharmacology, neuroscience, or related field
• Proficiency in multiple injection routes in rodents including subcutaneous, intravenous, intrathecal, and intracerebroventricular
• Experience conducting pharmacokinetic/pharmacodynamic studies in rodent models
• Expertise in rodent surgical techniques including stereotaxic injections and anesthesia monitoring
• Knowledge of rodent anatomy for necropsy procedures and tissue collection
• Familiarity with rodent behavioral assessment methods