Senior Director, Clinical Development (MD)

Madrigal Pharmaceuticals seeks a Senior Director, Clinical Development to lead strategic and operational oversight of its three clinical-stage programs across metabolic and liver diseases. This senior physician role demands deep medical expertise, regulatory acumen, and ability to manage complex, multi-study portfolios in a dynamic biotech setting.

Responsibilities

• Provide strategic clinical leadership across three programs and seventeen active studies; establish development milestones and risk mitigation strategies
• Lead design and medical oversight of Phase I–III trials including FIH, PoC, registrational, and outcomes studies
• Serve as clinical subject matter expert for regulatory interactions with FDA, EMA, and other health authorities
• Partner cross-functionally with Discovery, Translational Medicine, Nonclinical, CMC, Regulatory, and Commercial teams
• Review emerging data, conduct benefit–risk assessments, and guide adaptive development strategies

Requirements

• MD or MD/PhD with board certification in Internal Medicine, Gastroenterology, Endocrinology, Hepatology, or related specialty
• 10+ years clinical development experience across full drug development lifecycle; 15+ years total relevant experience
• Demonstrated success leading health authority interactions and regulatory engagements
• Proven ability to design clinical trials and make benefit-risk decisions with limited data
• Strong leadership presence with ability to influence internal and external stakeholders effectively
• Experience in liver disease, MASH/NASH, metabolic, cardiometabolic, or inflammatory pathways preferred
• Prior NDA/MAA submission leadership or outcomes study experience preferred