Program Manager

Program Manager – Capital Projects

Sigma Inc. is seeking an experienced Program Manager to lead the design, construction, and commissioning of a large-scale animal vaccine manufacturing facility in St. Joseph, Missouri.

This is an exciting opportunity for a seasoned capital projects professional with expertise in pharmaceutical manufacturing, biotechnology, life sciences, industrial construction, or large-scale facility expansions. The selected candidate will oversee all phases of project execution, from planning and design through construction, validation, commissioning, and operational readiness.

The ideal candidate will possess a strong background managing capital projects exceeding $100 million, working with cross-functional stakeholders, engineering teams, EPC firms, contractors, and executive leadership.

Key Responsibilities

Capital Project Leadership

• Lead end-to-end project delivery for the design, construction, commissioning, and startup of a large-scale vaccine manufacturing facility.
• Manage project scope, schedule, budget, resources, and deliverables to ensure successful execution.
• Oversee project planning activities, governance processes, risk management strategies, and performance reporting.
• Ensure project milestones are achieved on time and within budget.

Construction & Engineering Management

• Serve as the primary liaison between project stakeholders, architects, engineering firms, EPC contractors, construction teams, and equipment vendors.
• Coordinate design reviews, construction activities, equipment installation, commissioning, and facility startup activities.
• Monitor project progress and proactively resolve risks, delays, and resource constraints.

Cross-Functional Leadership

• Lead collaboration across Engineering, Operations, Quality Assurance, Validation, Manufacturing, Regulatory Affairs, Procurement, and Supply Chain teams.
• Influence executive stakeholders and drive strategic decision-making throughout the project lifecycle.
• Provide leadership across multiple departments and functional teams, both directly and indirectly.

Governance & Risk Management

• Establish project governance structures and reporting mechanisms.
• Maintain risk registers, mitigation plans, issue logs, and executive reporting dashboards.
• Ensure adherence to project controls, quality standards, and regulatory requirements.

Required Qualifications

• Bachelor's Degree in Engineering, Construction Management, Mechanical Engineering, Chemical Engineering, Biomedical Engineering, or related technical discipline.
• Extensive experience managing large-scale capital projects, facility expansions, or new construction projects.
• Proven experience delivering projects exceeding $100 million in capital investment.
• Strong understanding of Front-End Loading (FEL) processes and capital project lifecycles.
• Experience managing engineering, construction, commissioning, and startup activities.
• Demonstrated success leading cross-functional project teams.
• Exceptional communication, stakeholder management, and leadership skills.
• Strong analytical, organizational, and problem-solving abilities.
• Ability to work effectively in fast-paced, high-pressure project environments.

Preferred Qualifications

• Pharmaceutical manufacturing experience.
• Biotechnology or vaccine manufacturing facility experience.
• Life sciences, biologics, medical device, or regulated manufacturing industry experience.
• Experience working with EPC firms, contractors, and equipment suppliers.
• Familiarity with GMP-regulated manufacturing environments.
• Experience supporting facility commissioning, qualification, and validation activities.