Scientist, Immunology Cell Therapy Discovery (In Vitro Focus)

Overview Location: Cambridge, MA, USA AstraZeneca is a science-led biopharmaceutical company committed to transforming patient outcomes. We seek a curious, collaborative Scientist to advance novel cell therapies for autoimmune and immunology indications. This hands-on research role centers on in vitro work and cross-functional collaboration across our discovery teams. Role Overview : Design, optimize, and execute in vitro assays to identify and validate cell therapy targets for autoimmune and inflammatory diseases. Apply expertise with primary human cells, multiplex flow cytometry, cytokine detection, and assay development to generate impactful data and move programs from discovery to translation. Work closely with cross-functional groups to ensure rigorous science and timely milestones. Responsibilities In vitro discovery: Develop and run primary cell-based assays and co-culture systems; apply multiplex flow cytometry, cytokine detection, and advanced experimental design to validate targets and characterize engineered cell therapies (e.g., T cells, CAR-based modalities). Data & analytics: Apply a rigorous, data-driven approach to experimental design and decision-making; utilize analysis tools like FlowJo, OMIQ, and Prism. Collaboration: Work with engineering, genomics, translational science, and clinical teams; communicate plans and findings clearly across groups and to leadership; foster a collegial and collaborative lab environment. Project delivery: Maintain precise experimental documentation; collaborate on project planning, track progress, and focus on experimental efficiency to achieve milestones. Qualifications Education: MS with 3+ years, or BS with 5+ years industry experience in immunology, autoimmunity, cell therapy, or related field. In Vitro Expertise: Primary human cell culture, including functional immune cell-based assays and co-culture systems; multi-color flow cytometry and immunophenotyping; multiplex cytokine detection assays; assay development and optimization; experience with engineered cell products (e.g., T cell subsets, CAR-based modalities); familiarity with target discovery and CAR T transduction and/or gene editing. Data Proficiency: Strong experimental design, analysis, and interpretation; proficiency with FlowJo, Prism; ability to integrate complex datasets to guide decisions. Working Style: Demonstrated independence and adaptability in a dynamic environment; excellent record-keeping and reliable delivery to timelines. Communication: Clear, concise written and verbal communication; proven ability to communicate complex scientific concepts across multidisciplinary teams. Desired Qualifications And Skills Autoimmunity and inflammation experience: Familiarity with in vitro model systems for autoimmune and inflammatory conditions, such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease, etc. Industry background: Experience in pharmaceutical or biotech drug discovery and development. Compensation & Benefits The annual base pay for this position ranges from $92,252 – $138,378 USD. Base pay offered may vary depending on factors including market location, job-related knowledge, skills, and experience. The role offers a short-term incentive bonus opportunity and eligibility to participate in an equity-based long-term incentive program. Benefits include a qualified retirement program (401(k)), paid vacation and holidays, paid leaves, and health benefits (medical, prescription drug, dental, and vision) per plan terms. EEO & Accommodation Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. We welcome applications from all qualified candidates, regardless of protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. #J-18808-Ljbffr AstraZeneca