Principal Scientist, Pharmacokinetics

Principal Scientist – Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. We seek an experienced Principal Scientist to contribute to our biologics, drug conjugates, and novel modality discovery and development pipeline. Responsibilities Project‑team representative and subject matter expert for biologics drug discovery and development, including drug conjugates, multi‑specific biologics, and novel modalities. Contribute to overall team strategy and lead the formation and execution of team‑specific PDMB workflow. Design in vitro and in vivo mechanistic and translational studies to evaluate the pharmacokinetic and metabolic properties of therapeutic proteins, such as drug conjugates and other modalities, to influence drug design, lead selection, and drive PK/PD translations. Accountable for providing timely and high‑quality PDMB data deliverables to teams. Author regulatory documents from FIH through registrational filing. Partner across multidisciplinary interfaces and provide strategic DMPK guidance and support to drive new drug discovery and development. Contribute to departmental scientific initiatives and strategies. Foster a high‑performance culture of innovation, collaboration, engagement, self‑accountability, and inclusion. Stay abreast of external scientific advancements and contribute to the evaluation and implementation of new technologies and methodologies in DMPK for drug discovery. Qualifications Education: Ph.D. in a relevant scientific discipline (e.g., Pharmacokinetics, Pharmaceutical Sciences, Chemistry, Biochemistry, Biophysics, Biology, or related field) with a minimum of 8 years of industry experience; or MS Degree with a minimum of 12 years of relevant experience. Required Experience and Skills: Team‑facing experience leading DMPK efforts in biologics and conjugate discovery teams. A proven track record of setting strategies and priorities and managing resources as an independent project‑team representative within a highly dynamic and collaborative environment. Proficiency in analyzing, interpreting, and providing context around data describing the DMPK and PK/PD properties of therapeutic proteins; ability to extract preclinical PK/PD/efficacy relationships and translate PK/PD in humans. Demonstrated ability to effectively collaborate with cross‑functional teams and communicate DMPK findings to inform decision‑making in drug discovery and development. Strong problem‑solving and leadership skills, highly motivated and self‑driven with a keen interest in staying at the forefront of DMPK science and technology. Demonstrated experiences in mentoring and training junior scientists with a mindset of fostering variety and inclusion within the scientific community. Preferred Experience and Skills: Prior experience with multiple therapeutic modalities (e.g., small molecules, peptides, etc.) and/or novel modalities. Prior experience evaluating the biodistribution of large molecules in preclinical species. In‑depth understanding and experience in discovery bioanalytical science, including immunoassay, LC/MS. Demonstrated experience in translatable in vitro cellular models, biophysics/biochemistry assays and/or in vivo models. Understanding of modeling principles. Compensation Salary range: $176,200.00 – $277,300.00 (based on relevant factors). Eligible for annual bonus and long‑term incentive, if applicable. Benefits Medical, dental, vision, healthcare and other insurance benefits (for employee and family). Retirement benefits, including 401(k). Paid holidays, vacation, compassionate and sick days. Equal Opportunity Statement As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights, EEOC GINA Supplement. We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. #J-18808-Ljbffr MSD Malaysia