Director, Specialty Pharmacy Operations

Company Overview Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once‑daily, oral, liver‑directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high‑performing culture that values scientific excellence, operational rigor, and collaboration. Opportunity and Summary of Position The Director, Specialty Pharmacy Operations is responsible for directing, monitoring, and enhancing specialty pharmacy (SP) operations within Madrigal’s Market Access and Trade team. The Director manages dispensing operations across the channel to drive continuous improvement in patient access and adherence, while delivering a best‑in‑class patient and prescriber experience. The Director also collaborates with key internal stakeholders—MPS, Marketing, Data Analytics, Medical Affairs, Finance, Pricing & Contracting, Regulatory, Legal, and the Market Access field team—to identify patient access opportunities and implement impactful solutions. Additionally, the Director engages external stakeholders (e.g., SP’s and IDN’s) in day‑to‑day program operations and analysis of key data and KPIs to ensure contractual obligations are met or exceeded. This role has up to three direct reports and reports to the Executive Director, Trade and Specialty Distribution. Position Responsibilities Acquire and maintain deep understanding of NASH disease state, resmetirom clinical data, and commercialization strategy. Build, grow, and lead a team of specialty pharmacy operations specialists. Develop and implement the operational structure to support Madrigal’s specialty pharmacy network strategy; closely monitor SP performance to ensure contractual obligations are met or exceeded. Implement specialty pharmacy program services, enhancements, and operational efficiencies to positively impact patient access, adherence, awareness, and affordability. Maintain detail‑oriented SP program correspondence, call guides, and collateral via internal legal and regulatory approval processes. Partner with internal Patient Access and Data Analytics teams to continuously evaluate and analyze specialty pharmacy vendor performance relative to goals and objectives. Support Quarterly Business Reviews (QBRs) and other meetings with SP’s; prepare all materials, communicate expectations, and continuously drive performance while identifying key insights for strategic planning. Collaborate closely with Consumer Marketing and MPS teams to enhance the SP program and exceed the needs of HCPs and patients. Oversee brand planning initiatives, operational plans, project budgets, expenses, and timelines. Ensure timely and accurate reporting of adverse events received through the SP network; liaise with Pharmacovigilance and Medical Information teams on all escalations. Create and maintain necessary policies, procedures, and business rules for all distribution and dispensing programs. Consistently deliver measurable business outcomes based on program‑level key performance indicators (KPIs) and provide focused customer‑level reporting to leadership. Deliver enterprise‑wide impact, tackle complex projects, and influence change management across internal teams. Ensure the highest level of ethics, quality, and compliance by demonstrating in‑depth knowledge of laws governing market access and channel activities. Conduct all activities in compliance with all applicable federal, state and local laws, regulations, and company policies. Qualifications & Skills Bachelor’s degree required; advanced degree in Business or Pharmacy preferred. 12‑15+ years of related experience in the biopharma industry with a proven, consistent history of high performance in increasingly responsible leadership roles. 7‑10 years of healthcare industry customer/vendor management experience strongly preferred. 5+ years of experience operationalizing specialty pharmacy programs and networks required. Experience with specialty distribution operations preferred. Ability to develop insights from data trends to improve program performance. Experience with pre‑launch drugs and new product launches preferred. Ability to work effectively within a cross‑functional team and in an environment of rapid change. Excellent written, organizational, verbal, presentation, and communication skills a must. Proficient in MS Office products including PowerPoint, Word, and Excel. Travel (approximately 20%). Benefits and Compensation Competitive Total Rewards strategy includes base salary, bonus, equity, and a generous benefits package. Full‑time employees are eligible for base salary, bonus, equity, and a comprehensive benefits suite. Base salary is estimated at $223,000 – $273,000 per year, based on qualifications, skills, education, experience, business needs, and market demands. All full‑time employees receive equity and are eligible for a 401(k) plan with employer match. Benefits encompass flexible paid time off, medical, dental, vision, and life/disability insurance, supplemental life insurance, legal services, and additional voluntary benefits. Mental health benefits are available through the Employee Assistance Program. Equal Opportunity & Accommodations Madrigal is an Equal Opportunity Employer. All employment is determined on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact View email address on click.appcast.io. How to Apply Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. #J-18808-Ljbffr Madrigal Pharmaceuticals Corporation