Principal Scientist Biophysical Characterization

Verve Therapeutics is a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, a clinical‑stage genetic medicines company established to solve the global health epidemic of cardiovascular disease. Founded by world‑leading experts in cardiovascular medicine, human genetics and gene‑editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single‑course gene‑editing medicines. The Analytical Development Group within Verve is comprised of a diverse team of analytical chemists, molecular biologists and pharmaceutical scientists delivering product and process understanding to the LNP‑gene therapy systems. Responsibilities The Analytical Development group is responsible for developing and implementing new analytical methods, as well as optimizing and improving current methods for the characterization of raw materials, RNA drug substances, and LNP products and programs at various development stages. Additionally, the role includes testing non‑GMP samples to support development studies such as comparability assessments, process development, stability, product, and process characterization. The position is part of a Technical Operations team that partners closely with Quality Control, Quality Assurance, Process Development, and Analytical Research & Development. Develop, optimize, and execute analytical methods intended for a variety of purposes, including release and stability testing, product characterization, high‑throughput analysis, and characterization of complex raw materials. Collect, process, and analyze experimental data and information applying HPLC, UHPLC, capillary electrophoresis, LCMS, MALS and/or other instrumental analysis techniques, ensure accurate and timely documentation in electronic laboratory notebook. Review, interpret, and present data within the analytical team and cross‑functional. Author, review, and revise technical source documents to support phase‑appropriate comparability. Provide technical oversight to guide analytical/QC investigations, as needed. Actively collaborate with internal and external process development and quality teams. Train and mentor junior team members. Basic Requirements MS in analytical chemistry, biochemistry, biophysics or a related field with 4+ years of experience in Biotech or Biopharmaceutical industry OR BS in analytical chemistry, biochemistry, biophysics or a related field with 6+ years of experience in Biotech or Biopharmaceutical industry Minimum of 3 years of experience in LC and CE assay development required Hands‑on experience developing, qualifying and troubleshooting biophysical assays using HPLC/UPLC, LCMS and capillary electrophoresis (CE). Additional Preferences Strong technical background on analytical methodologies using CE and HPLC for gRNA, mRNA, LNPs. Experience in method transfer, validation, and implementation to support target candidate validation from non‑GxP to GMP environments. Experience in advanced characterization instrumentation such as cryo‑TEM, NMR, FFF‑MALS, DLS, NTA, DSC, AUC etc. Familiarity with applicable ICH regulations related to method validation. Proactive, creative, and positive attitude. Effective oral and written communication skills. Qualified applicants must be authorized to work in the United States on a full‑time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F‑1 CPT, F‑1 OPT, F‑1 STEM OPT, J‑1, H‑1B, TN, O‑1, E‑3, H‑1B1, or L‑1. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 - $187,000. Full‑time employees will also be eligible for a company bonus (depending, in part, on company and individual performance) and a comprehensive benefit program, including 401(k) participation, pension, vacation benefits, eligibility for medical, dental, vision and prescription drug benefits, flexible benefits, life insurance, and well‑being benefits. #J-18808-Ljbffr Eli Lilly and Company