Executive Assistant, Technical Operations

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Executive Administrative Assistant provides high-level, strategic administrative and operational support to the Executive Vice President, Technical Operations and the Technical Operations leadership team. This role serves as a trusted partner to their executive leaders, ensuring seamless operational execution, proactive prioritization, and exceptional coordination across Quality, Supply Chain and CMC, and cross collaboration with all other departments. This is a highly visible role requiring executive presence, sound judgment, discretion, and the ability to anticipate needs in a fast-paced, growth-oriented biotech environment. The ideal candidate operates with a strategic mindset, demonstrates exceptional organizational agility, and thrives in managing complex, shifting priorities while maintaining absolute confidentiality. This role is empowered to act as an extension of executive leadership, representing their interests and making informed decisions on their behalf as appropriate. This position is based in the Waltham, MA office, requiring onsite presence at least three days per week. Key Responsibilities: Executive Calendar, Time & Priority Management Strategically maintain complex calendars and schedules for executive leadership Proactively anticipate conflicts, recommend tradeoffs, and protect executive focus Executive Partnership & Stakeholder Liaison Serve as a primary liaison between executives and internal/external stakeholders Represent executive leadership with professionalism, discretion, and sound judgment Travel, Expense & Administrative Operations Coordinate and proactively monitor end-to-end executive travel, providing real-time support to resolve delays, disruptions, or logistical challenges while minimizing impact to executive schedules Develop detailed travel itineraries and contingency plans aligned with executive priorities and business needs Manage and reconcile executive expenses with accuracy, timeliness, and adherence to company policies and compliance requirements Leadership Team Enablement & Operational Execution Coordinate leadership team meetings, agendas, and follow‑up on key actions and deliverables Provide high‑level administrative and operational support critical to leadership effectiveness Develop and maintain efficient systems for information, documents, and workflows Cross‑Functional Leadership, Projects & Mentorship Lead or support cross‑functional projects and operational initiatives Partner with and support the broader administrative team to ensure continuity and coverage Serve as a mentor and informal leader to the broader administrative staff Confidentiality, Judgment & Professionalism Handle sensitive information with the highest level of confidentiality and professionalism Travel Requirement Some travel is required for team offsite meetings, to the Conshohocken PA office, and potentially other meetings such as Executive Leadership Team offsites, Board of Directors meetings, etc. Required Qualifications: 10+ years of progressive administrative experience, including direct support of C-level executives Proven ability to manage complex schedules, shifting priorities, and high‑visibility work Strong judgment, executive presence, and stakeholder management skills Highly organized, proactive, and solutions‑oriented Advanced proficiency in Microsoft Office Suite (Outlook, PowerPoint, Word, Excel, Teams, SharePoint) Desired Qualifications: Bachelor’s degree preferred Prior experience in a biotech, pharmaceutical, and/or publicly traded company strongly preferred Experience supporting finance, business development, or other corporate leadership functions Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $104,000 - $127,000 per year. We comply with all applicable minimum wage laws. All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact View email address on click.appcast.io. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to View email address on click.appcast.io. Join our growing team focused on transforming the treatment of people with liver diseases. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.