Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

CHIEF OF Staff

Pear VC

About Optexity Optexity is a product-driven research lab building clinical reasoning and computer use models on data no other lab can reach. We deploy directly inside clinics and hospitals — including systems with no APIs, using integration infrastructure we've built and open-sourced — and in return become their preferred partner. That gives us proprietary clinical reasoning trajectories from practicing physicians, and a feedback loop between real patient encounters, our models, and the products built on top of them. We're a small, fast-moving founding team with multiple published papers in NeurIPS, ICML, CVPR etc and background from Apple, Amazon, Microsoft, CMU, IIT. We are backed by world-class investors and leaders like Jeff Dean, Neotribe VC, PearVC, Together Fund and Zapier Fund. How we work Customer obsession — we start with the customer and work backwards Intellectual honesty — ideas matter more than titles; we communicate directly and assume good intent, even in disagreement Bias for action — we build and learn with customers rather than debate in the abstract Extreme ownership — we own outcomes, not just tasks, and see problems through About the role This is not an EA role, and not a strategy role — it's a hands-on generalist operator who owns the business, legal, and people infrastructure that lets a small team move fast without breaking. You'll be the person who makes sure the company runs: contracts get signed, people get paid, compliance holds up, and nothing critical falls through the cracks. You'll work directly with the founders and build the operational backbone from close to zero. Why this role exists Legal, HR, accounting, payroll, compliance, and day-to-day operations all sit on the founders' plates today, alongside product and engineering. In a healthcare company, this surface area is heavier than usual — BAAs, HIPAA and state privacy obligations, and customer contracts can't be an afterthought. We need one person to own all of it end to end: not just execute tasks, but build the systems, vendor relationships, and processes so these functions run reliably as we scale. What you'll do Legal & contracts — manage outside counsel, own the contract lifecycle (customer agreements, BAAs, NDAs, vendor and consulting agreements), and keep corporate housekeeping in order: cap table administration, board and investor documents, entity and state registrations Compliance — own the operational side of HIPAA and state privacy compliance, coordinate audits and security certifications (e.g. SOC 2) as they come up, and maintain the policies, records, and vendor due-diligence that customers and regulators expect HR & people ops — run onboarding/offboarding, offer letters, benefits and PEO administration, immigration/visa support for the team, and keep employee policies and records clean and current Accounting & payroll — own bookkeeping oversight with our accountants, run payroll and contractor payments, manage AP/AR, expenses, banking, and the monthly close Everyday operations — manage vendors, software and tooling, insurance, and the logistics of a fast-growing team; be the default owner for the operational thing no one else is holding Founder leverage — take ambiguous operational problems off the founders' plates, structure them, and drive them to done What we look for A generalist who's comfortable owning many unrelated functions at once and context-switching cleanly between them Strong execution and follow-through — you close loops and things don't slip Highly organized and detail-oriented, with good judgment about what's genuinely important vs. merely urgent Operates in ambiguity and builds process where none exists, without waiting for perfect instructions Trustworthy with sensitive legal, financial, and personnel information Willing to do unglamorous, high-value work Fast learner with genuine interest in the operational and regulatory side of a healthcare company Nice to have Prior chief-of-staff, business ops, or startup operations experience Exposure to legal, HR, finance, or compliance functions Familiarity with healthcare compliance (HIPAA, BAAs) or other regulated environments Experience standing up processes and vendors at an early-stage company What you get Direct, daily work with the founders, plus exposure to board and investor conversations True zero-to-one scope — building the operational foundation of the company, not executing a fixed playbook Competitive salary and meaningful equity #J-18808-Ljbffr

Vacancy posted 2 days ago
Similar jobs that could be interesting for youBased on the CHIEF OF Staff in San Francisco, CA vacancy
  •  ...Lyft is in a defining moment — from turnaround to international growth, from traditional rideshare to the autonomous future. The Chief of Staff to the CEO sits at the center of that transformation, serving as a force multiplier for CEO David Risher and the senior... 
    Suggested
    Hourly pay
    Work at office
    Local area

    Lyft

    San Francisco, CA
    21 hours ago
  • $150k - $200k

     ...effective and accountable government and the vision of high-performance government for every community at OpenGov.com.Role OverviewAs Chief of Staff to the CEO, you will sit at the center of how this company operates and makes decisions. You will own the operating cadence,... 
    Suggested
    Contract work
    Work at office
    Local area

    OpenGov

    San Francisco, CA
    3 days ago
  • $281k - $330k

     ...highly strategic role, you will partner with executives and senior leaders both across the business and within the Product org. As Chief of Staff reporting directly to the CPO, you will have an immediate impact on our CPO’s productivity from day one, streamlining strategic... 
    Suggested
    Work at office
    Local area
    Immediate start
    Remote work
    Relocation
    3 days per week

    Checkr

    San Francisco, CA
    4 days ago
  • $206k - $284k

     ...an opportunity to do career-defining work. We're all in on this mission. If you are too, let's talk.Director/Senior Director, Chief of Staff – Global People TeamReports to: Chief People OfficerLocation: SF Bay Area (SF HQ a minimum of 2x week) Role OverviewThe Director... 
    Suggested
    Work at office
    Local area
    Worldwide
    Flexible hours
    Shift work

    Okta

    San Francisco, CA
    1 day ago
  •  ...Chief of Staff Location: San Francisco Employment Type: Part-time (Contract) Location Type: Hybrid Compensation: based on experience About Jinba We help large enterprises build automated workflows using plain English. Unlike traditional no-code tools... 
    Suggested
    Full time
    Contract work
    Part time
    Bank staff

    Jinba.io

    San Francisco, CA
    21 hours ago
  •  ...looking for thoughtful, driven people excited to work at the intersection of AI, Security, and Infrastructure. About This Role As Chief of Staff to the CEO, you'll operate at the center of the company working directly with the CEO and executive team as the company scales... 
    Work at office

    DepthFirst AI, Inc.

    San Francisco, CA
    3 days ago
  •  ...Chief of Staff to the Chief Executive Officer (CEO) About the Company Innovative provider of cloud-based financial services for local & national governments Industry Computer Software Type Privately Held, VC-backed Founded 2012... 
    Contract work
    Local area

    Confidential

    San Francisco, CA
    4 days ago
  •  ...liquidity that someone else sold back. So that's what we make: a liquid market for GPU offtake. About The Role SF Compute is seeking a Chief of Staff to the CEO to serve as a strategic partner and force multiplier to the CEO. This role combines strategy, operations, and... 
    Long term contract
    Contract work
    Fixed term contract
    Work at office
    Local area
    Visa sponsorship
    Shift work

    The San Francisco Compute Company

    San Francisco, CA
    1 day ago
  • $135k - $175k

     ...Capital and NVP Capital, looking for builders who want to solve hard problems. The Role & Culture We are seeking a sharp, organized Chief of Staff to support HomeVision’s CEO and company operations. This role is focused on acting as a strategic operational partner to the... 
    Flexible hours

    HomeVision

    San Francisco, CA
    4 days ago
  • $300 per month

     ...ambitious team run by scientists and engineers from leading institutions across biology, physics, chemistry, and AI. Role This is Chief of Staff to Sam Rodriques, Edison Scientific's co-founder and CEO. This role is one of the highest-leverage seats in the company: you... 
    Work at office

    Edison Scientific

    San Francisco, CA
    2 days ago
  •  ...leader. This is a rare opportunity to join a company at an inflection point and help shape what it becomes. Role Overview The Chief of Staff to the CEO is a strategic operator role, not an administrative one. You will serve as the CEO’s force multiplier: owning high‑stakes... 

    Rzr Co

    San Francisco, CA
    4 days ago
  • $256k - $320k

     ...xAI, Notion, Coinbase, and Palantir, among others Build a massive, fast‑growing business with billions in revenue The Role The Chief of Staff to the CEO is one of the highest‑leverage roles at Handshake — a seat at the center of our most consequential decisions as we enter... 
    Full time
    Freelance
    Internship
    Work at office
    Remote work
    Flexible hours

    Handshake

    San Francisco, CA
    4 days ago
  • Company Thunder Compute is building the VMware for GPUs. We have raised over $17M from Matrix Partners, Y Combinator, and leading angels from CoreWeave, Microsoft, Cognition, and Anthropic. Deployed GPU fleets are currently only 5–20% utilized. Existing solutions generally...
    Full time
    Work at office
    Visa sponsorship
    Relocation package

    Thunder Compute

    San Francisco, CA
    21 hours ago
  •  ...tl;dr: We're automating compliance for banks and fintechs with AI agents that work like human analysts. We're looking for a Chief of Staff to work directly with the CEO — someone who can operate across every function of the business, make the founder faster, and ensure... 
    Temporary work
    Work at office
    Relocation package
    Shift work

    Sphinx

    San Francisco, CA
    1 day ago
  •  ...to restructure how all of that work gets done, and no tool is built for that transition yet. About the Role We're looking for a Chief of Staff to work shoulder to shoulder with our founder and help run the company. This is a strategic, full-stack role: you'll help set... 
    H1b
    Immediate start

    Luzidos Inc.

    San Francisco, CA
    4 days ago
  •  ...We are looking for a Chief of Staff to join our team in SanFrancisco. In this role, you will work directly with the CEO on initiatives across product, marketing, and operations. This is a part‑time role, with the potential to transition into a full‑time role based on... 
    Full time
    Part time

    Finvest

    San Francisco, CA
    2 days ago
  • $150k - $175k

     ...together. About You Most business education happens from a distance. This role puts you in the room where it's made. We're hiring a Chief of Staff who gets genuine energy from making things run well, and who wants to learn how a real company grows by doing the actual work,... 
    Temporary work
    Work at office
    Local area
    Worldwide
    Monday to Friday
    Flexible hours
    3 days per week

    Vsco39

    San Francisco, CA
    2 days ago
  • $110k - $150k

     ...I'm hiring for a Chief of Staff role at a Series A AI startup in San Mateo. The company has raised $41M, has a team of roughly 55 people across engineering, sales, and go-to-market, and has had zero engineering attrition since founding. They're now investing heavily in... 
    Work at office
    Remote work
    Relocation
    Visa sponsorship

    Benchstack Ai

    San Francisco, CA
    21 hours ago
  •  ...Chief of Staff Job Posting Starting July 2026 Classification: Regular, Full-time, Non-exempt, 12-month, Staff Reporting to: Head of School The Chief of Staff role at Urban School of San Francisco serves as a key advisor to the Head of School and is a member of the school... 
    Full time
    Part time
    Work at office
    Local area
    Night shift
    Afternoon shift

    CL 09c91187 9509 4724 8127 8bc8bd1e052f

    San Francisco, CA
    2 days ago
  •  ...are partnering with leading AI labs to push AI closer to achieving its transformative potential. About the Role We are hiring a Chief of Staff to own how Preference Model runs internally, so the founders spend their time on customers, fundraising, and strategy. You will... 
    Work at office

    Socket

    San Francisco, CA
    4 days ago
  •  ...locations, the potential cost of missed context, misaligned decisions, or decisions made with insufficient data is increasing. The Chief of Staff role makes sure that cost isn’t realized. You'll partner closely with the CEO and leaders across commercial, engineering,... 
    Flexible hours

    Lydian

    San Francisco, CA
    1 day ago
  • $100k - $250k

     ...backed by Floodgate, Peak XV, and YC — and we've been doubling every 3 months since inception. Now we're looking for a cracked Chief of Staff to be the founder’s force multiplier and help run the company. We don't want someone to "manage calendars." We want someone who... 
    Full time
    Work at office

    Blue Jay Inc.

    San Francisco, CA
    4 days ago
  •  ...Menlo, and Anthropic, we are moving with relentless focus to deploy the economic substrate for autonomous agents. About the Role Chief of Staff to the CEO — a high‑trust, high‑agency role at the center of the company. The CEO architects the product and vision; you... 
    Interim role

    Sapiom

    San Francisco, CA
    3 days ago
  •  ...Asana seeks a Chief of Staff to the Chief Product Officer to translate priorities into an effective operating rhythm, align Product, Engineering, and Design, and drive the key forums, communications, and strategic work that let leaders make better decisions faster. This... 
    Work at office

    Decisive Point

    San Francisco, CA
    1 day ago
  •  ...Building category-defining infrastructure for enterprise AI workforce orchestration, the business is carving out a high-leverage Chief of Staff seat to sit directly alongside founder leadership. This is a high-velocity, high-impact mandate for a high-agency operator.... 

    Alexander Chapman

    San Francisco, CA
    14 hours ago
  • $234k - $275k

     ...As Chief of Staff to the Chief Product Officer, you will be a force multiplier for Asana's product leadership team. This role helps the CPO run a high-functioning organization by translating priorities into an effective operating rhythm, keeping Product, Engineering,... 
    Work at office
    Local area
    Work from home
    Worldwide

    Decisive Point

    San Francisco, CA
    1 day ago
  •  ...Were hiring a Chief of Staff to work directly with the founders of a fast-growing AI healthcare startup. Youll take ownership of the problems that matter most across operations, sales, product, customer success, engineering and hiring. The remit is broad, the pace is... 
    Full time
    Relocation

    Arevna

    San Francisco, CA
    3 days ago
  • $120k - $180k

     ...environments. Experience as a founder, founding-team member, or high-performing generalist in growth, operations, GTM, BizOps, or Chief of Staff work. The ability to build outbound and GTM systems. Familiarity with Claude Code, ChatGPT, agents, and workflow automation. A... 
    Immediate start
    Visa sponsorship

    Raydar Inc

    San Francisco, CA
    14 hours ago
  •  ...advising, may also manage an independent program and / or professional staff engaged in a range of administrative functions. Under the...  ...subordinate managers. Partnering with Vice and Associate Chairs, Division Chiefs and Administrative Directors, ensures consistent interpretation... 
    Contract work
    Temporary work
    Work experience placement
    Work at office
    Worldwide

    UCSF Health

    San Francisco, CA
    2 days ago
  •  ...manage local transmission between generation, storage, and loads. The Role This is not an administrative or assistant role. As the chief of staff at the office of the CEO, you will: Stand up new functions from zero to one, owning them until they’re ready to hand off.... 
    Work at office
    Local area
    Long distance

    American Terawatt

    San Francisco, CA
    1 day ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to CHIEF OF Staff. Be the first to apply!