Senior Director/Executive Director, DMPK

Job Summary Iambic Therapeutics is seeking an experienced DMPK leader to lead our Drug Metabolism & Pharmacokinetics function. Reporting to senior leadership, you will define the scientific strategy for DMPK from early discovery through IND-enabling studies. You will collaborate with internal and external partners to plan and execute DMPK studies. This is a high-impact, hands‑on leadership role for someone who thrives at the intersection of rigorous science and strategic drug development. Key Responsibilities Lead and manage all DMPK strategy and execution across Iambic's discovery programs, setting clear goals and ensuring alignment with cross‑functional program teams. Design and oversee non‑clinical ADME/PK studies and PK/PD modeling to enable candidate selection and accelerate IND filings. Serve as the internal DMPK subject matter expert, partnering with medicinal chemistry, biology, toxicology, and clinical teams to interpret data and guide program decisions. Build and manage a high‑performing network of CRO partners and academic collaborators to supplement internal capabilities. Lead preparation and review of DMPK sections for regulatory submissions including INDs and NDAs; interact with health authorities as needed. Champion compliance with ICH guidelines, FDA regulations, and industry best practices across all DMPK activities. Contribute scientific expertise to business development, due diligence, and partnership evaluations. Stay at the forefront of emerging DMPK science, technologies, and regulatory trends to continuously strengthen the function. Qualifications PhD in Pharmacokinetics, Pharmaceutical Sciences, or closely related discipline or PharmD. 12+ years of experience in the pharmaceutical or biotechnology industry, with at least 3 years of leadership experience in DMPK. Proven experience in designing, conducting, and interpreting DMPK studies supporting small molecule oncology programs. Experience with regulatory submissions is required. Expertise in regulatory requirements and industry standards for DMPK studies (ICH guidelines, FDA regulations, etc.). Excellent communication, collaboration, and leadership skills. Ability to work independently and manage multiple priorities in a fast‑paced, team‑oriented environment. Pay and Benefits We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state‑of‑the‑art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play. Compensation range: $224K – $310K #J-18808-Ljbffr Iambic