Post Doctoral Scholar - Physiology & Cell Biology

Post Doctoral Scholar Physiology & Cell Biology Department: Medicine | Physiology and Cell Biology The Neginskaya Laboratory in the Department of Physiology and Cell Biology at The Ohio State University invites applications for a Postdoctoral Scholar position to investigate the molecular mechanisms of mitochondrial permeability transition. Mitochondrial permeability transition is a stress-induced increase in the permeability of the inner mitochondrial membrane that contributes to cell death and tissue injury in cardiovascular, neurological, and other diseases. Current projects focus on the structural organization of mitochondrial membrane protein complexes under stress, the molecular mechanisms underlying mitochondrial permeability transition, and the signaling pathways that regulate mitochondrial dysfunction. The laboratory employs an interdisciplinary approach that integrates mitochondrial patch-clamp electrophysiology, advanced live-cell and label-free imaging, structural biology (cryo-electron tomography and cross-linking mass spectrometry), and biochemical and molecular approaches. The Postdoctoral Scholar will pursue specialized research training, education, and experience under the guidance of Dr. Neginskaya; plan, design, and execute experiments of considerable scope and complexity to investigate the mechanisms and role of mitochondrial dysfunction in ischemia-reperfusion injury in the heart and brain; collect and analyze data for research sponsored by the National Institutes of Health (NIH) and other funding agencies; identify and investigate significant research questions; develop and troubleshoot new experimental techniques and protocols; attend research seminars; contribute to manuscript preparation and scientific writing; and participate in the preparation of grant applications for extramural funding. Minimum Education and Skills/Experience Required/Desired A PhD in biochemistry, cell biology, biophysics, physiology, or a related field is required, along with a strong publication record, the ability to work independently and collaboratively, and excellent written and verbal communication skills. Candidates should have experience in one or more of the following areas: mitochondrial biology, membrane protein biochemistry, electrophysiology, live-cell microscopy, cryo-electron microscopy (cryo-EM) or cryo-electron tomography (cryo-ET), structural biology, quantitative image analysis, mouse models, or bioenergetics. Our laboratory places a strong emphasis on scientific integrity, transparency, and ethical conduct. We seek team members who value honesty, take ownership of their work, and contribute to a supportive and respectful research environment. The successful candidate will have the opportunity to develop independent research projects, learn unique experimental approaches, contribute to interdisciplinary studies of mitochondrial biology, and present their work at national and international scientific conferences. Additional Information Location: Graves Hall (0277) Position Type: Term (Fixed Term) Scheduled Hours: 40 Shift: Varying Shifts Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process. The university is an equal opportunity employer, including veterans and disability. Ohio State benefits give you options to take care of what matters most to you - and opportunities to make adjustments as your life and needs change. Medical, dental and vision coverage, with Ohio State paying a significant portion of the cost. Paid time off, including sick and vacation time and 11 holidays. State retirement plan or an alternative retirement plan, both with generous employer contributions. As Buckeyes, we accomplish more together. No matter your role, you'll be part of creating what people need now: pathways to education, research and health care. Working at Ohio State means you're part of a team with a strong sense of community and an unwavering commitment to excellence - and, of course, incomparable Buckeye spirit. We bring out the best in people, help each other succeed and learn together. By joining Ohio State, you become part of a top-20 public university with one of America's leading academic health centers. We're a team of dedicated colleagues with access to boundless resources that support you. Thank you for your interest in positions at The Ohio State University and Wexner Medical Center. #J-18808-Ljbffr Ohio State University