Senior Scientist I, Biology

Job Description Summary #LI-Onsite Location: Cambridge, MA This role is located in Cambridge, MA. Please only apply if this area is accessible to you. This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. About the Role: The Novartis Biomedical Research Oncology Disease Area is seeking an experienced scientist to join the Target Biology and Discovery (TBaD) group. The mission of our group is to uncover novel therapeutic targets and effective modalities to benefit cancer patients. By leveraging cutting-edge technologies, innovative screening approaches, and in-depth mechanistic studies, the team initiates the crucial first steps in bringing new oncology medicines to the clinic. Job Description Key Responsibilities: We are seeking a dedicated and innovative Senior Scientist to join our chromatin biology team within the TBaD group. Lead mechanism‑of‑action studies using advanced cell biology and chromatin biology approaches to interrogate therapeutic response. Design, develop, and execute in vitro assays to elucidate key aspects of cancer biology. Leverage state-of-the-art genome-editing tools to perform genetic screens and support compound mechanism-of-action studies. Design, execute, analyze, document experiments, and communicate results in team settings. Stay current with scientific literature and advancements Collaborate across departments and with external partners to foster growth and innovation within the team and department, and contribute to the culture of the group, are key aspects of this role Essential Requirements: B.S or M.S. in Biochemistry, Molecular Biology, Cell Biology, Cancer Biology or related field. Experience performing Chromatin-Based experiments is Essential Strong proficiency in mammalian cell culture, molecular biology (vector design, cloning), protein analysis workflows (e.g. Western blotting, FACS), and CRISPR-based gene editing technologies (e.g. base editing, prime editing, CRISPRi, CRISPRa, etc.). Clear track record of working efficiently with teams. Strong interpersonal, organizational and communication skills, with a commitment to fostering a collaborative and innovative work environment. Ability to manage multiple projects simultaneously and deliver high-quality results. A creative, curious, passionate, and scientifically fearless mindset dedicated to improving the lives of patients. Demonstrates strong critical thinking and independent problem-solving skills. Desirable Requirements: Proficiency with data mining, computational skills, and chromatin-based analyses Previous research related to hormone driven cancer cell biology (e.g. prostate and breast cancer) The salary for this position is expected to range between $93,8000 and $174,200 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. To learn more about the culture, rewards and benefits we offer our people click here. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to View email address on click.appcast.io or call View phone number on click.appcast.io and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $93,800.00 - $174,200.00 Skills Desired Analytical Skill (Inactive), Analytical Skill (Inactive), Analytical Thinking, Chemical Biology, Chemistry, Clinical Research, Clinical Trials, Collaboration, Communication Skills (Inactive), Curious Mindset, Data (Inactive), Data Analysis, Design of Experiments (DOE), Detail-Oriented, Diversity and Inclusion (D&I), Drug Discovery Process, Ethics, Gene Therapy, Immunology, Laboratory (Inactive), Leading Project Teams, Lifesciences (Inactive), Machine Learning (ML), Mammalian Cell Culture, Medical Research {+ 11 more} Improving the lives of people living with disease takes more than innovative science. It takes a focus on the needs of people and a community committed to meeting them. It takes a team of people like you. Working together. Learning together. Thriving together. Discover how you can join us in changing people’s lives. 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