Scientist, Cell Therapy Process Development (In Vivo CAR-T)

Overview Challenging. Meaningful. Life‑changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high‑achieving teams. Take your career farther than you thought possible. Read more: careers.bms.com/working-with-us. About the Cell Therapy Thematic Research Center The Cell Therapy Thematic Research Center (CT TRC) is one of BMS’s differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. The team focuses on developing next‑generation, engineered cell‑based therapies and is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes. Position Summary The CT‑PRE team is seeking a Scientist to help translate next‑generation cell therapies from early research into robust development platforms. The Scientist will design and execute laboratory experiments both independently and collaboratively, contributing to a highly interactive, matrixed, agile, team‑driven environment. The ideal candidate will have prior industry experience with process development, preferably in viral vector production for CAR‑T therapy. Role Design and conduct laboratory experiments to evaluate gene delivery and cell engineering strategies for CAR‑T manufacturing feasibility. Lead workstreams focused on optimizing and implementing scalable lentiviral vector production for in‑vivo CAR‑T platforms. Document experimental workflows, results, and deviations in electronic laboratory notebooks to ensure reproducibility and process understanding. Perform data analysis and communicate findings clearly to enable informed decision‑making by research and development teams. Participate in cross‑functional project teams and effectively communicate CT‑PRE activities, data, and recommendations. Collaborate closely with team members to coordinate experimental execution and deliver study outcomes. Train and mentor junior team members as appropriate. Demonstrate strong scientific rigor through critical thinking, problem‑solving, troubleshooting, and attention to detail. Basic Qualifications Bachelor’s Degree: 5+ years of academic and/or industry experience. Master’s Degree: 3+ years of academic and/or industry experience. Ph.D. or equivalent advanced degree in the Life Sciences: No experience necessary. Preferred Qualifications Experience with viral vector process development, including upstream production (e.g., suspension culture, transfection parameters, bioreactor scale‑up) and downstream purification and concentration strategies. Experience developing and optimizing bioprocesses intentionally designed for scalability into STR culture and manufacturability. Strong understanding of viral transduction mechanisms, tropism and integration. Proficiency with aseptic mammalian cell culture, preferably including primary T cell culture, activation and expansion. Familiarity with analytical characterization and critical quality attributes for an in‑vivo CAR‑T drug product (titer, purity, potency, sterility). Understanding of T‑cell biology and immunology relevant to CAR‑T – activation, transduction efficiency, phenotype and functional assays. Experience with T‑cell manufacturing workflows – apheresis material handling, activation, gene delivery, expansion, formulation. Understanding of statistical design‑of‑experiments methodology and data analysis for process optimization. Familiarity with lipid nanoparticle (LNP) or other nanoparticle‑based delivery systems for in‑vivo and/or ex‑vivo T‑cell targeting and engineering. Knowledge of, or hands‑on experience with, site‑specific gene‑editing (preferably CRISPR‑Cas, base or prime editing) technologies. Working knowledge of analyzing and interpreting data from flow‑based cellular, and PCR/sequencing based molecular assays. Awareness of incorporation of cell‑targeting ligands in vectors, for in‑vivo T‑cell or organ‑selective targeting. Effective written and verbal communication skills for exchanging technical and scientific information with cross‑functional teams. A collaborative team player who can effectively multi‑task as well as excel independently in a fast‑paced, dynamic and innovative environment. Compensation Overview Seattle – WA: $122,810 – $148,814 per year. The starting compensation range is for a full‑time employee basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, visit Benefits Health Coverage: Medical, pharmacy, dental, and vision care. Well‑being Support: Programs such as BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP). Financial Well‑being and Protection: 401(k) plan, short‑ and long‑term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support. Paid Time Off & Other Work‑Life Benefits US Exempt Employees: flexible time off (unlimited, with manager approval), 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico, or Rayzebio employees). Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non‑Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays. Unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs, and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part‑time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown. EEO & Accommodation Information BMS is an equal opportunity employer. We are dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, direct your inquiries to View email address on click.appcast.io. For complete Equal Employment Opportunity statement, visit We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. If you believe the job posting is missing information required by local law or incorrect in any way, please contact BMS at View email address on click.appcast.io. Provide the Job Title and Requisition number for review. R1601507 : Scientist, Cell Therapy Process Development (In Vivo CAR‑T) #J-18808-Ljbffr Bristol Myers Squibb