Scientist

Job Description

Job Description

Description:

• The Biologics CMC Developability (BCD) group sits at the interface of discovery and development.

• The core role of BCD is to generate developability insights that inform candidate selection, molecular optimization, and advancement decisions across biologics pipeline.

• Developability assessments focus on identifying manufacturability, formulation, stability, and product quality risks early in development to enable selection of robust drug candidates.

• Our team works across a wide range of therapeutic areas and diverse classes of biologics therapeutics, including monoclonal antibodies, bispecific and multispecific antibodies, antibody drug conjugates (ADC), fusion proteins, and emerging biologic modalities.

• We are looking for a highly motivated person to support these developability efforts and early-stage assessment of candidates to move ever-evolving pipeline forward.

• In this role, the candidate will be part of a global team and will work closely with scientists from multiple functional areas, including Discovery, Analytical, and Process R&D.

• Support candidate screening activities by executing characterization studies including conformational stability assessment via differential scanning fluorimetry/calorimetry experiments, solution viscosity determination, and other techniques

• Evaluate drug candidate chemical and physical stability against different solution conditions (pH, ionic strength, temperature, light, etc.) and physical stresses arising from manufacturing process conditions (freeze thaw, mixing, filtration, filling, and lyophilization)

• Communicate scientific findings and development risks through clear presentations and technical reports to cross-functional teams and senior stakeholders

• Stay current with the literature and support new scientific initiatives

Qualifications:

• BS or MS in Biochemistry, Chemistry, Pharmaceutical Sciences, Chemical Engineering, Bioengineering, or a related scientific discipline and typically 4 (BS) or 2 (MS) years of relevant experience

• Experience with formulation, protein stability, or developability assessment of therapeutic biologics is strongly preferred

• Strong laboratory skills focused on chemical and structural characterization of biologics (HPLC/UPLC, SEC, capillary electrophoresis, icIEF, particle analysis, DLS, DSF, DSC, UV-Vis, and related developability assessment techniques)

• Scientific understanding of the structure and function of monoclonal antibodies, antibody constructs/conjugates, bispecifics, and fusion proteins and their modes of degradation

• Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance

• Excellent oral communication skills in a scientific setting, as well as sound technical writing and documentation competency

• The candidate must be able to work independently, respond to changing priorities and short lead times for multiple tasks; able to identify problems and work toward solutions

• Demonstrates scientific curiosity and continuously seeks opportunities to improve experimental approaches, efficiency, and data quality

• Fosters collaboration, values diverse scientific perspectives, and translates innovative ideas into practical solutions

Benefits:

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance: Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first of the month following at least 1 calendar year after employment begins.

Synectics is an equal opportunity employer.

Synectics is a leading staffing and workforce solutions company dedicated to connecting exceptional talent with top organizations. We specialize in IT, engineering, finance, healthcare, and professional services recruitment, offering both contract and permanent staffing solutions. With a people-first approach, we focus on understanding the unique needs of our clients and candidates to create long-term, successful matches. Our mission is to empower businesses with the right talent while helping professionals achieve rewarding career opportunities

Company Description

Synectics is a leading staffing and workforce solutions company dedicated to connecting exceptional talent with top organizations. We specialize in IT, engineering, finance, healthcare, and professional services recruitment, offering both contract and permanent staffing solutions. With a people-first approach, we focus on understanding the unique needs of our clients and candidates to create long-term, successful matches. Our mission is to empower businesses with the right talent while helping professionals achieve rewarding career opportunities