FL114: Senior Scientist, Therapeutics Engineering

FL114: Senior Scientist, Therapeutics Engineering Cambridge, MA USA About FL114 FL114 is an innovative, privately held biotechnology company developing our novel epigenetic editing platform to treat a variety of diseases through precise, tunable modification of gene expression. FL114 was founded by Flagship Pioneering, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. With a strong emphasis on innovation and experimental execution, FL114 cultivates a highly dynamic and entrepreneurial environment. About the Role FL114, Inc. is seeking a Senior Scientist to join our integrated Platform as a key contributor in our Therapeutics Engineering efforts. The successful candidate will be an essential member of a close-knit team of experimental and computational scientists driving FL114’s product generation engine and supporting a broad set of therapeutic programs. We are looking for enthusiastic, detail-oriented, adaptive, and highly motivated individuals with a passion for bringing novel medicines to patients. Applicants should be comfortable working on a fast-paced, cross-functional scientific team. Key Responsibilities Independently conduct, optimize and proactively troubleshoot cellular screening assays in a wide range of primary and transformed cell lines. Expression and functional characterization of novel biologics modalities using various cell systems and techniques (cell-based assays, RNA/DNA/protein isolation and detection techniques, RT-qPCR, flow cytometry, etc.) Drive, pilot, and oversee development of a wide range of cutting‑edge assays. Design, procurement, and maintenance of combinatorial libraries for relevant cell‑based and cell‑free assays. Identification and management of external partners (CROs, CMOs, etc). Required Skills Execute routine and advanced molecular biology techniques, including plasmid preparation, RT-qPCR, cloning, RNA/DNA extraction, gel electrophoresis, oligo pool work, etc. Culture and maintain a wide variety of mammalian cell lines, including transient and stable transfections. Develop cell lines as necessary. Analyze and interpret assay data, maintain accurate laboratory notebooks, and communicate results clearly in team meetings. Drive optimization and automation of screening protocols, including the use of liquid handling systems and plate readers. Experience with gene delivery technologies (for example LNP, lentivirus, etc.). Exposure to CRISPR-based or other gene editing technologies. Exposure to NGS data sets and its interpretation. Familiarity with data analysis tools such as GraphPad Prism, Benchling, SnapGene, etc. Adaptive and detail-oriented with excellent time management and organization skills. Exceptional teamwork and communication skills. Required Qualifications PhD in Cell or Molecular Biology, Biochemistry, or related disciplines with 2+ years of relevant experience in biotech or pharma. Strong background in cellular and molecular biology with hands‑on experience in the development and optimization of cell‑based assays and library screening assays. Extensive experience in gene design, vector construction, and protein expression. Possession of strong communication skills, both written and verbal, to clearly convey results and scientific data to senior leaders, teams and partners. Industry experience in drug discovery or pharmaceutical R&D preferred. Benefits Salary range: $126,000 - $159,500. Healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Privacy Notice for Applicants When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI‑assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact View email address on click.appcast.io. Diversity & Inclusion We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. #J-18808-Ljbffr Flagship Pioneering