Principal Scientist, QSP — Multiscale Disease Modeling
Sanofi
Sanofi in Cambridge, MA, seeks a Principal Scientist to lead Quantitative Systems Pharmacology modeling across programs. You will develop multiscale disease models, integrate data, and communicate predictions to stakeholders to inform drug discovery and development. You will collaborate with biology, chemistry, and translational teams, apply machine learning and differential equation models, and contribute to strategy, methodological advances, and training of team members. #J-18808-Ljbffr Sanofi
$146k - $236k
...portfolio of AI-first companies. As part of Flagship’s integrated model of science, entrepreneurship, and capital, it transforms... ...success by integrating uncertainty across compound, mechanism, and disease dimensions Translate scientific complexity into recommendations...Principal$122.25k - $176.58k
Job Title: Principal Scientist, Systems and Disease BiologyLocation: Cambridge, MAAbout the JobAs a Principal Scientist within our Systems and Disease... ...deployment of innovative algorithms and computational models.Leading projects involving internal experiment design and...PrincipalFull time- Job Title: Principal Scientist, Quantitative Systems Pharmacology Location... ...Systems Pharmacology (QSP) group as a Principal Scientist... ...portfolio with mechanistic disease modeling. Join the engine of Sanofi... ...team to develop and apply multiscale computational models of complex...PrincipalInternship
- ...an experienced, creative, and talented Principal Scientist, ML (LLMs) to join our team. You will be... ...training state-of-the-art, large-scale models on the scientific corpora, fine-tuning... ...people against COVID-19, curing intractable diseases, improving human health, preempting...Principal
- Sanofi is seeking a Principal Scientist in Cambridge, MA to decode disease mechanisms at cellular resolution and pioneer AI-powered workflows that accelerate discovery to patient impact. The role demands deep expertise in complex cellular analytics, multi-omics, and ML...Principal
$138.6k - $257.4k
...highly motivated and experienced scientist to lead a small group of... ...discovery and validation across disease areas. This position is part... ...Job Title: Senior Principal Scientist/Associate DirectorPosition... ...including cellular and tissue-based models, with hands on experience in...PrincipalFull time$148.5k - $214.5k
Job title: Senior Principal Scientist Type 2 ImmunologyLocation:Cambridge, MAAbout the JobImmunology... ...and murine immunology and inflammatory disease pathways Experience with advanced... ...biopsies (skin, lung, gut), mouse disease models, and or organoid systemsExperience contributing...PrincipalFull time$146k - $236.5k
...stealth AI x bio company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations. Here... ...at the interface of structure-based modeling and generative ML, turning simulation... ...against COVID-19, curing intractable diseases, improving human health, preempting...Principal$208k - $286k
...directions. We are looking for a Senior Principal Scientist to invent and build the next generation... ...methods that enable populations of models, hypotheses, programs, or scientific representations... ...against COVID-19, curing intractable diseases, improving human health, preempting...Principal$173.2k - $272.6k
...seeking an accomplished and highly motivated Principal Scientist to provide strategic and scientific... ...that integrate therapeutic mechanism, disease biology, pharmacodynamics, patient... ...Pathology, Dedication to Patient Care, Disease Models, Disease Research, Imaging Biomarkers,...PrincipalFull timeFor contractorsLocal areaFlexible hours$216k - $297k
...companies. As part of Flagship’s integrated model of science, entrepreneurship, and... ...for a team of talented machine learning scientists innovating on model architectures that will... ...people against COVID-19, curing intractable diseases, improving human health, preempting...Principal$142.5k - $256.5k
...an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within... ...across oncology and autoimmune disease programs. The role spans concept development... ...analysis, bioinformatics, structural modeling, AI/ML-enabled discovery tools, or...PrincipalPermanent employmentFull timeWork from home$255.8k - $402.7k
...exciting opportunity for a physician-scientist to join our group as a Principal Scientist (Clinical Director) in... ...Area specifically focuses on diseases affecting the central and peripheral... ..., biostatistics, drug metabolism, modeling and simulation, regulatory affairs...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hours$176.2k - $277.3k
...Metabolism and Bioanalytics - Principal ScientistOur company is a... ...and collaborative Principal Scientist (director-level equivalent) to... ...neuroscience and infectious disease efforts as well. The successful... ...pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin,...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hours$208k - $286k
...companies. As part of Flagship’s integrated model of science, entrepreneurship, and... ...and beyond. THE ROLE We are seeking a Principal Scientist (Embedded ML/Computational) to lead AI/... ...people against COVID-19, curing intractable diseases, improving human health, preempting...Principal- ...biotherapeutics development go hand in hand. As a Scientist, PK/PD Modeling & Simulation, you will be responsible... ...PK, PK/PD, exposure-response and QSP models to support model-informed drug... ...is preferred: biologics PK/PD, rare disease development, translational modeling,...
- ...seeking an accomplished and highly collaborative scientist to lead the Cellular Biology function. The ideal candidate... ...on experience developing cell‑based translational models of genetically defined human hematologic diseases, and strong mechanistic expertise in cell...Principal
$119.7k - $222.3k
...Summary Location: Cambridge MA Internal: Principal Scientist I/II LI#-Hybrid The individual will... ...- $222,300.00 Skills Desired Animal Models, Bioinformatics, Collaboration, Communication... ...the lives of people living with disease takes more than innovative science. It...PrincipalPermanent employment- ...Bristol Myers Squibb seeks a Principal Scientist for its Discovery BioSciences Genomics team in Cambridge... ...applying genomic approaches to disease biology, target validation, and biomarker... ...cell culture and complex cellular models Ability to work cross-functionally with...Principal
$114.1k - $211.9k
...milestones.Develop integrated biomarker plans encompassing assays, models, samples, analyses, timelines, and external partnerships.... ...including target engagement, pharmacodynamics, patient stratification, disease activity, and mechanism-based biomarkers.Experience leading...PrincipalFull timeLocal areaFlexible hours$108.5k - $201.5k
...disciplines, Drug Disposition (ADME, BA), Modeling & Simulation (M&S), and Operations... ...clinical development to be considered for Principal Scientist II ~ Extensive and in-depth... ...Why Novartis: Helping people with disease and their families takes more than innovative...Principal$108k - $128k
...Principal Associate Scientist Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated... ...medicines for patients with serious diseases by unlocking biologically important... ...western blot across 2D and 3D cell models. Develop, optimize, and qualify new...PrincipalShift work- We are seeking a Senior Principal Scientist to join the US Neuromuscular group based in Cambridge,... ...and execution of in vitro and in vivo models as well as cellular and biochemical assays... ...populations, including neuromuscular diseases related to nucleotide repeat expansions...PrincipalLocal area
$142.5k - $256.5k
...Moderna is seeking a highly motivated Principal Scientist Mass Spectrometry to join the Cancer Vaccine... ...approaches relevant to infectious disease or oncology. Familiarity with Bruker... ...Curious and Collaborative. Our Working Model As we build our company we have...PrincipalPermanent employmentFull timeWork from home$106k - $176.6k
...Inflammation & Immunology Research Unit seeks a Principal Scientist to lead preclinical in vivo pharmacology... ...strategy for neuroinflammatory and neurodegenerative diseases. The role combines scientific leadership, advanced model development, and cross-functional team...Principal$220k - $270k
Principal or Senior Principal Scientist - Peptide & Bioconjugate Drug Discovery Does it excite you to build next... ...capabilities in metabolic disease? If this sounds like you, and you are... ...interpret and apply computational modeling and design insights, and familiarity...Principal$260.3k - $409.7k
...Research Division with the role focused on Cardiovascular Disease and related conditions. The Principal Scientist (Clinical Director) must have a strong background... ...research, biostatistics, drug metabolism, modeling and simulation, regulatory affairs, and global clinical...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hours$192k - $265k
...creative, rigorous, and execution-oriented machine learning scientist to join our Model-Driven Design team. This role will focus on building the... ...pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational...Work at officeShift work$108.5k - $201.5k
...Description SummaryInternal Position Title: Principal Scientist I/IILocation: Cambridge, MA, #LI-Onsite... ...biomarker assay development within Disease Area X (DAx). This position is integral... ...disease areas.Familiarity with animal models and ex vivo assays is a plus.Hands-on experience...PrincipalFull timeRelocation package- ...seeking an accomplished, creative, and highly collaborative scientist to lead the Cellular Biology function. The ideal... ...hands-on experience developing cell-based translational models of human hematologic diseases. This leader will play a pivotal role in advancing the...Principal
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