Director of IT

A Rare Opportunity to Shape the Future of Genomics

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.

If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

We are seeking a dynamic and experienced Director of IT to oversee and manage our Dev Ops and IT strategy. The ideal candidate will have a strong background in networking, infrastructure management, AWS cloud services and cybersecurity. This role will be pivotal in maintaining and enhancing our IT systems to support our business operations and growth. The Director of IT is a hybrid position (onsite 2‑3 days per week) and reports to the VP of IT/IS.

Key Responsibilities

• IT Leadership and Strategy:
  • Develop and implement IT strategies aligned with the company's scaling goals.
  • Lead and manage the IT team, fostering a culture of excellence and continuous improvement.
  • Oversee the design, implementation, and maintenance of the company's cloud infrastructure and set it up as a service for the organizations.
• Networking and Infrastructure:
  • Ensure the reliability, security, and efficiency of our networking systems.
  • Manage network configuration, performance monitoring, and troubleshooting.
  • Oversee the setup, configuration, and maintenance of servers, storage, and other infrastructure components.
  • Implement and manage disaster recovery and business continuity plans.
• AWS Cloud Management:
  • Design and manage AWS cloud infrastructure, ensuring scalability, performance, and security.
  • Oversee the strategy, deployment and management of AWS services, including EC2, S3, RDS, and VPC.
  • Optimize cloud resources for cost‑efficiency and performance.
  • Implement and manage cloud security policies and procedures.
• Security and Compliance:
  • Ensure IT security measures are in place and regularly updated to protect against data breaches and cyber threats.
  • Ensure compliance with industry standards and regulations, including HIPAA, SOC 2 and other relevant guidelines.
  • Conduct regular security audits and vulnerability assessments.
• Project Management:
  • Lead IT projects from conception through completion, ensuring they are delivered on time and within budget.
  • Collaborate with cross-functional teams to support IT needs for various initiatives.
  • Manage vendor relationships and negotiate contracts for IT services and products.
• Support and Maintenance:
  • Oversee the IT support function to ensure timely resolution of technical issues and maintain a high standard of service satisfaction.
  • Maintain an inventory of IT assets and manage lifecycle processes.
  • Implement IT policies and procedures, ensuring staff adherence.

Qualifications

• Bachelor's degree in Computer Science, Information Technology, or a related field. A Master's degree is a plus.
• Minimum of 8 years of experience in IT, with at least 3 years in a managerial or leadership role.
• Extensive experience with networking technologies, infrastructure management, and AWS cloud services.
• Proficiency in networking technologies (LAN, WAN, VPN, firewall, etc.).
• Strong knowledge of server and storage systems, virtualization, and data centers.
• Expertise in AWS services, architecture, and best practices.
• Experience with IT security protocols and compliance standards, SOC 2 preferred.
• Excellent leadership and team management skills.
• Strong problem-solving and decision‑making abilities.
• Effective communication and interpersonal skills.
• Ability to manage multiple projects and priorities in a fast‑paced environment.

Benefits And Perks

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for eligible employees (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Free daily on‑site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on‑site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of (1) competitive base pay, (2) the opportunity for professional growth, and (3) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave etc.).

The base salary range for this role is $217,585 - $271,981. This position is eligible for an annual bonus and receives a new hire equity grant of up to $150,000 at grant value, vesting over four years, plus annual equity refresh grants equal in value to the new hire grant. Together, the total four‑year value of base, target bonus, and equity is up to approximately $1.7 million. We also offer competitive medical and dental coverage and a 401(k) with company match.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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Our Impact

Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample.

Unity Confirm™ enables non-invasive confirmation for high-risk screening results through the capture of intact circulating fetal cells using BillionToOne’s Fetal Cell Capture™ Technology.

Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth

From $0 to $400M+ annualized revenue run-rate in just 6 years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding, including our $130M Series D in 2024 and backed by world‑class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition

Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified, with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.

Our Future

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.