Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Senior / Principal Neuromorphic Systems Architect

$150k - $250k

Seres Therapeutics, Inc.

The CompanyFlagship Labs 119 Inc. (FL119) is an early-stage technology company pioneering a new frontier at the intersection of neuroscience and computation. We are developing next-generation technologies to transform how intelligent systems are built. We believe that the future of artificial intelligence demands a fundamental rethinking of today’s paradigms. Our mission is bold and urgent: to build a future where naturalistic, robust intelligence can emerge and operate sustainably at scale.FL119 is backed by Flagship Pioneering, which brings the courage, long-term vision, and resources needed to realize unreasonable results. At FL119, we are uniquely cross-functional and collaborative. Our teams thrive in unstructured and creative environments. All voices are heard because we know that experience comes in many forms, skills are transferable, and passion goes a long way.The Role:FL119 is seeking a creative and deeply technical Neuromorphic Systems Architect to join our team. Leveling is flexible based on experience.This role will focus on translating nonlinear neural dynamics into next-generation computational architectures. You will work at the interface of neuroscience, dynamical systems theory, and hardware engineering to design and prototype electronic architectures that embody biologically derived principles of computation.This is not a conventional AI accelerator role. We are seeking someone who can rethink compute from first principles, designing architectures that leverage recurrence, nonlinearity, sparsity, event-driven signaling, and adaptive dynamics as foundational primitives rather than constraints.How You Will Contribute:Formalize brain-derived computation using dynamical systems theory and translate these insights into hardware-relevant abstractions.Architect novel neuromorphic or neuro-inspired hardware systems (analog, mixed-signal, in-memory, or alternative substrates).Define system-level architecture, including memory models, communication schemes, and energy-efficient compute primitives.Collaborate with neuroscience, signal processing, and machine learning teams to ensure tight coupling between biological insight and architectural design.Lead feasibility studies, simulations, and early-stage prototyping efforts.Evaluate trade-offs across CMOS, emerging devices, photonic, memristive, or other unconventional compute substrates.Contribute to IP strategy, including invention disclosures and patents.Help shape the long-term compute vision of the company.Must-have Qualifications:PhD (or equivalent experience) in Electrical Engineering, Applied Physics, Computational Neuroscience, Computer Engineering, or a closely related field.Deep expertise in nonlinear dynamical systems and their application to computation.Experience designing hardware architectures (ASIC, FPGA, analog/mixed-signal, or emerging device technologies such as RRAM, PCM, memristors, etc.).Strong mathematical foundation in dynamical systems, control theory, or computational modeling.Demonstrated ability to move from theory to implementable system design.5+ years of relevant research or industry experience (level dependent)Preferred Experience:Prior work in neuromorphic computing or spiking neural network hardware.Experience with event-driven or asynchronous architectures.Familiarity with reservoir computing, recurrent dynamical systems, or physical computing substrates.Experience working in early-stage, fast-paced R&D environments.Track record of patents or high-impact publications in neuromorphic systems or unconventional computing.ABOUT FLAGSHIP PIONEERINGFlagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at .At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.#LI-MB1The salary range for this role is $150,000 - $250,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL119 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL119's good faith estimate as of the date of publication and may be modified in the future.Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact View email address on click.appcast.io.

Vacancy posted 4 days ago
Similar jobs that could be interesting for youBased on the Senior / Principal Neuromorphic Systems Architect in Cambridge, MA vacancy
  • $150.4k

     ...join our innovative and inclusive community. Join us as a Principal Systems Architect, where you will lead the design, development, and operations...  ...-based research computing infrastructure, serving as the senior technical authority for IaaS, PaaS, and SaaS platforms... 
    Principal
    For contractors
    Work experience placement

    Boston University

    Boston, MA
    2 days ago
  • $95k - $275k

     ...and Enabling Technologies Division is seeking a Principal Digital Engineering Solution Architect to apply systems-thinking and advanced methodologies to developing...  ...Specific responsibilities will include:• Work with senior leaders across Draper to analyze and capture... 
    Principal
    Full time
    Local area

    Draper Laboratory

    Cambridge, MA
    4 days ago
  • Reference: 628547Posted: 2026-07-27Location: Boston, MassachusettsCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** are seeking a highly skilled Scientist to join our Biologics Discovery team and lead antibody discovery efforts...
    Principal
    Senior

    Planet Pharma

    Boston, MA
    1 day ago
  • $140k - $190k

     ...career.We are seeking a highly experienced Full Stack Java Senior Developer / Architect to lead the design and development of scalable, high-...  ...developing API-centric applications and integrating distributed systems.Solid experience in front-end development using Angular (... 
    Senior
    Full time
    Local area

    Brown Brothers Harriman

    Boston, MA
    3 days ago
  • $137k - $215.27k

     ...submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Pharmacovigilance Scientist, Senior Scientist ensures regulatory compliance and safety of Takeda's products by managing large projects, developing innovative solutions... 
    Principal
    Senior
    Minimum wage
    Temporary work
    Local area

    Takeda

    Cambridge, MA
    3 days ago
  •  ...Senior Director, Principal Gifts About the Company Philanthropic organization supporting Indigenous culture & individuals Industry Non-Profit Organization Management Type Non Profit Founded 2017 Employees 11-50 Categories ~ Non-Profit &... 
    Principal
    Senior

    Confidential

    Boston, MA
    2 days ago
  •  ...our engineering team and looking for a driven, detail-oriented Senior Electrical Design Engineer to take ownership of complex hardware...  ...the intersection of rigorous circuit design, DFM, and embedded systems - and who wants to see their work shipped in real-world,... 
    Senior

    Nanobiosym

    Cambridge, MA
    17 days ago
  •  ...electrical engineer responsible for the design, development, and integration of electronics for Nanopath's diagnostic platform Own system-level electrical architecture, including PCB design, power management, signal integrity, and integration with embedded software and... 
    Principal
    Senior
    Full time
    Work at office

    Nanopath

    Cambridge, MA
    24 days ago
  • $168k - $240k

     ...realize their desired business outcomes. We accelerate the growth of more impactful work and the evolution of Slalom.The Role: M&A Principal/Senior PrincipalWhat You’ll Do:* Delivery areas include:* Executing operational due diligence* Creating integration strategies, plans... 
    Principal
    Senior
    Temporary work
    Work at office
    Local area
    Immediate start

    Slalom

    Boston, MA
    4 days ago
  • Senior Principal Engineer. Healthcare, Boston, MA. Hybrid, 150 - 190kCompensation Commensurate with experience, bonus, benefits, EOE, diverse...  ...overall design and development of our Infusion Management System.ResponsibilitiesExtend existing interoperability solution to... 
    Principal
    Senior
    Permanent employment

    BlueSkyClarity

    Boston, MA
    4 days ago
  • $220k - $269.5k

     ...THE ROLEWe are seeking an Operating Principal to help launch and scale our NewCos. You will work across one or more companies, leading...  ...application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We... 
    Principal
    Senior

    Seres Therapeutics

    Cambridge, MA
    1 day ago
  • Senior to Principal Data Engineer (SQLserver, Financial Services), Boston, MA. Hybrid, min 3 days week in office, 135k to 175k base on experienceCompensation Commensurate with experience, EOE, diverse highly educated culture Candidates must be a U.S. citizen or national... 
    Principal
    Senior
    Permanent employment
    Contract work
    Work at office
    Local area
    3 days per week

    BlueSkyClarity

    Boston, MA
    4 days ago
  • $115k - $215k

     ...protein mass spectrometry (MS) assays using state-of-the-art LC-MS systems—including nano-LC and Orbitrap platforms.Generate...  ...scientific findings and strategic recommendations to project teams, senior leadership, and external collaborators in a clear, concise, and... 
    Principal
    Senior

    Kymera Therapeutics

    Watertown, MA
    3 days ago
  •  ...s a lot of work to do, and we'd love your help. About You You have experience building and supporting production software systems You are great at asking questions, figuring out what needs to be done, building consensus, and executing You love learning new... 
    Principal
    Senior

    Roberts Recruiting

    Boston, MA
    3 days ago
  • $126k - $234k

    Job Description Summary#LI-Hybrid Internal Title: Principal Scientist II or Senior Principal ScientistLocation: Cambridge, MANovartis is a leader in...  ...to support clinical programs, applying quantitative systems pharmacology (QSP) and mechanistic PBPK/PD approaches to... 
    Principal
    Senior
    Full time

    Novartis

    Cambridge, MA
    1 day ago
  • Job DescriptionPathology Senior Principal Research Scientist, Vertex Pharmaceuticals (Boston)Preclinical Safety Assessment (PSA) is a global function responsible for the design and conduct of comprehensive nonclinical safety programs for the evaluation of Vertex therapies... 
    Principal
    Senior
    Full time
    Contract work
    Summer work
    Flexible hours

    Vertex Pharmaceuticals

    Boston, MA
    1 day ago
  • $119.7k - $222.3k

     ...overseeing ADME/DMPK project strategy in clinical development, or in AI strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist.Extensive and in-depth knowledge of pharmacokinetics including, drug... 
    Principal
    Senior
    Full time

    Novartis

    Cambridge, MA
    1 day ago
  • $138.6k - $257.4k

    Job Description SummaryLocation: Cambridge LI#Onsite The Oncology Pathology and Biomarkers group within Oncology Translational Research at Novartis Biomedical Research is seeking an accomplished Imaging Scientist to join the Image Analysis team in Cambridge.This role is...
    Principal
    Senior
    Full time

    Novartis

    Cambridge, MA
    4 days ago
  • $148.5k - $214.5k

    Job title: Senior Principal ScientistLocation: Cambridge, MAAbout the JobWe are seeking a highly motivated Senior Principal Scientist to spearhead...  ...compelling growth. Our deep understanding of the immune system - and innovative pipeline - enables us to invent medicines... 
    Principal
    Senior
    Full time

    Sanofi

    Cambridge, MA
    4 days ago
  • $143k - $214.5k

     ...agriculture. We are seeking an innovative and strategic Senior Scientist II or Principal Scientist, Sequencing Technologies to lead the vision, development...  ...is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening... 
    Principal
    Senior

    Seres Therapeutics

    Cambridge, MA
    4 days ago
  • $148.5k - $214.5k

    Job title: Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease GenomicsLocation: Cambridge, MAAbout the JobJoin Sanofi's Target, Disease and Systems Biology (TDSB) team and become a key contributor to our Disease Genetics and Genomics cluster.... 
    Principal
    Senior
    Full time

    Sanofi

    Cambridge, MA
    2 days ago
  • $188k - $282k

    Job DescriptionPosition SummaryVertex is seeking a Sr. Principal AI Engineer, Agentic AI Platform & Control Tower Ops to define and build...  ...generation (RAG), orchestration frameworks, evaluation systems, and platform architecture.In addition to building out the core... 
    Principal
    Senior
    Full time
    Summer work

    Vertex Pharmaceuticals

    Boston, MA
    1 day ago
  •  ...The Position Senior Principal Statistician A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more... 
    Principal
    Senior
    Local area

    Genentech

    Boston, MA
    22 hours ago
  •  ...the gap between algorithm development and deployment to embedded systems. In this role you will lead the architecture and...  ...teams to build robust code repositories and CI/CD processes. Architect and implement complex workflows spanning code parsing, semantic... 
    Principal
    Senior
    Full time
    Remote work
    Relocation package
    Flexible hours

    Code Metal

    Boston, MA
    22 hours ago
  • $188k - $282k

     ...DescriptionPosition SummaryVertex is seeking a Sr. Principal AI Engineer, Agentic AI Platform to...  ...with deep experience in applied AI systems. This individual will be comfortable...  ..., and reusable platform components. The Senior Principal AI Engineer will play a critical... 
    Principal
    Senior
    Full time
    Summer work

    Vertex Pharmaceuticals

    Boston, MA
    1 day ago
  • $230k - $295k

     ...and everyone is a stakeholder.As a Sr. Principal Product Manager on the Circle product team...  ...the network.Create Scalable Growth Systems for Developers: Partner with Data Science...  ...infrastructure for money.Collaborating with senior product leadership and other product... 
    Principal
    Senior
    Flexible hours

    Circle

    Boston, MA
    18 hours ago
  • $108k - $209k

     ...an experienced, creative, and talented Principal / Senior Software Engineer. The ideal candidate...  ...continued development. Design scalable system architecture for rapidly evolving, AI-enabled...  ...AWS Certifications, such as Solutions Architect Associate or Professional. Able to... 
    Principal
    Senior

    Seres Therapeutics

    Cambridge, MA
    2 days ago
  • Senior, Principal or Lead Software Engineer, Artificial Intelligence, fully remote, 145k to 195k base, bonusCompensation Commensurate with experience...  ...Software Engineer who is responsible for helping lead the systems development and deployment of AI-based products and platforms... 
    Principal
    Senior
    Permanent employment
    H1b
    Remote work
    Visa sponsorship

    BlueSkyClarity

    Boston, MA
    4 days ago
  • $160k - $180k

     ...opportunity for a new team member to join their Boston-based Technology Governance Risk Audit & Compliance (GRAC) team as a Technology Senior Risk Analyst. In this newly created role, the Technology Senior Risk Analyst will support and mature the Technology Risk Management... 
    Principal
    Senior
    Temporary work
    Flexible hours

    Berkshire Hathaway Specialty Insurance

    Boston, MA
    4 days ago
  • $177.6k - $266.4k

    Job DescriptionGeneral Summary:The Senior Principal, Source to Pay Technology will provide technical expertise, delivery, and support for Source...  ...and downstream platformsDesign, perform and document system configurations within in-scope platforms and applicationsContribute... 
    Principal
    Senior
    Full time
    Contract work
    Work experience placement
    Summer work
    Remote work
    Flexible hours
    2 days per week

    Vertex Pharmaceuticals

    Boston, MA
    18 hours ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Senior / Principal Neuromorphic Systems Architect. Be the first to apply!